Moro orange juice prevents fatty liver in mice

作     者：Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano 

作者机构：Department of Internal MedicineUniversity of Catania95123 CataniaItaly Department of Drug SciencesUniversity of Catania95125 CataniaItaly Department of Experimental OncologyEuropean Institute of Oncology20141 MilanItaly Department of PathologyUniversity of Catania95123 CataniaItaly Department of GastroenterologyTel Aviv Sourasky Medical CenterTel-Aviv 64239Israel 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第29期

页      面：3862-3868页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver steatosis Anthocyanins Lipogenesis Lipid oxidation 

摘      要：AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced ***:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 *** morphology,gene expression of lipid transcription factors,and metabolic enzymes were ***:Mice fed HFD displayed increased body weight,insulin resistance and *** juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total *** fed HFD showed liver steatosis associated with *** Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid ***,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 ***:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.