Prevalence of celiac disease in adult patients with refractory functional dyspepsia:Value of routine duodenal biopsy

作     者：Emiliano Giangreco Cinzia D'agate Carmelo Barbera Lidia Puzzo Giuseppe Aprile Pietro Naso Giacomo Bonanno Alessandra Nicoletti Salvatore Incarbone Giuseppe Trama Antonio Russo Francesco Paolo Russo 

作者机构：Department of Surgery Gastroenterology and Endoscopy Unit University of Catania Department of Surgical and Gastro-enterological Sciences Gastroenterology Section University of Padova 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第45期

页      面：6948-6953页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Celiac disease Endoscopy Biopsy Functional Dyspepsia 

摘      要：AIM: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gas-troenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional ***: Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duo-denal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber ***: The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.