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Characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia Pavón Pivetta leonardo Benedini Paulo Marcos Ma.Agustina Cócola Mercedes Virginia Barros Daniel Gregori leonardo Strazzere Anderson costa dos Santos Mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates

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Journal of Animal Science and Biotechnology 2018年第3期9卷 618-629页

作者： Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli leonardo nanni costa Paolo Bosi Paolo Trevisi Department of Agricultural and Food Sciences (DISTAL) Alma Mater Studiorum-University of Bologna

Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their ***: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' ***-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns'

关键词： Colostrum 1H–NMR spectroscopy Metabolome Pig breeds Piglets survival

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Distinct T helper cell-mediated antitumor immunity:T helper 2 cells in focus

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Cancer Pathogenesis and Therapy 2023年第1期1卷 76-86页

作者： Rafael Cardoso Maciel costa Silva Marcela Freitas Lopes leonardo Holanda Travassos Laboratory of Immunoreceptors and Signaling Carlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil Laboratory of Immunity Biology George DosReis Carlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

The adaptive arm of the immune system is crucial for appropriate antitumor immune *** is generally accepted that clusters of differentiation 4^(+)(CD4^(+))T cells,which mediate T helper(Th)1 immunity(type 1 immunity),are the primary Th cell subtype associated with tumor *** this review,we discuss evidence showing that antitumor immunity and better prognosis can be associated with distinct Th cell subtypes in experimental mouse models and humans,with a focus on Th2 *** aim of this review is to provide an overview and understanding of the mechanisms associated with different tumor outcomes in the face of immune responses by focusing on the(1)site of tumor development,(2)tumor properties(i.e.,tumor metabolism and cytokine receptor expression),and(3)type of immune response that the tumor initially ***,we discuss how low-tolerance organs,such as lungs and brains,might benefit from a less tissue-destructive immune response mediated by Th2 *** addition,Th2 cells antitumor effects can be independent of CD8^(+)T cells,which would circumvent some of the immune escape mechanisms that tumor cells possess,like low expression of major histocompatibility-I(MHC-I).Finally,this review aims to stimulate further studies on the role of Th2 cells in antitumor immunity and briefly discusses emerging treatment options.

关键词： Cancer Immunology Adaptive immunity Immunotherapy Immunogenetics Antitumor immune response

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Metabolomics characterization of colostrum in three sow breeds and its influences on piglets’ survival and litter growth rates.

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畜牧与生物技术杂志(英文版) 2018年第3期

作者： Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli leonardo nanni costa Paolo Bosi Paolo Trevisi

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Subterranean termites （Isoptera： Rhinotermitidae）： Exploitation of equivalent food resources with different forms of placement

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Insect Science 2012年第3期19卷 412-418页

作者： Juliana Toledo Lima Ana Maria costa-leonardo Departamento de Biologia Instituto de BiocienciasUNESP-Univ Estadual PaulistaRio Claro-SPBrazil

Coptotermes gestroi and Heterotermes tenuis have been described as important urban pests in Brazil. The establishment of control technologies using baits that consider the social behavior of termites requires a better knowledge of their foraging behavior. Thus, this study analyzed the feeding behavior of these species with three different forms of food placement： food on the surface of a substrate and food either partially or completely buried in the substrate. Experimental arenas were composed of a central chamber connected to three food chambers. Each central chamber contained 550 foragers of C. gestroi or 517 foragers of 11. tenuis. Blocks of Pinus elliottii were placed in the different food chambers. After 28 days, the consumption of each wood block and the percentage of foraging individuals recruited for food chambers were verified in relation to the total survival rate obtained for each one of the 20 replicates. Results showed that completely buried food was most consumed for H. tenuis and presented a higher recruitment rate of workers and soldiers for both species. Although the consumption had non-significant differences for C. gestroi, these termites exhibited a tendency to prefer completely buried food. In these conditions, it can be concluded that the forms of food placement used in the present research influenced the recruitment of individuals for both species. Data also suggests that when the foraging subterranean termites find food resources in the tunneling substrate, they tend to concentrate their efforts on it, a behavior regime that reduces exposure to external environment.

关键词： Coptotermes gestroi feeding behavior foraging behavior Heterotermes tenuis

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Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties

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Bioactive Materials 2023年第12期30卷 46-61页

作者： Soumya Saha Raphael Cavalcante costa Mirela Caroline Silva Joao Matheus Fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorative Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improved ***,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating magnesium atomic

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Predictive modeling for wine authenticity using a machine learning approach

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Artificial Intelligence in Agriculture 2021年第1期5卷 157-162页

作者： Nattane Luíza da costa leonardo A.Valentin Inar Alves Castro Rommel Melgaço Barbos Instituto de Informática Universidade Federal de GoiásGoiânia-GoBrazil Informatics Nucleo Goiano Federal Institute of EducationScience and TechnologyCampus UrutaíRodovia Geraldo Silva Nascimentokm 2.5Zona RuralBloco de InformáticaUrutaíGOBrazil LADAF Department of Food and Experimental NutritionFaculty of Pharmaceutical SciencesUniversity of São PauloAv.Lineu Prestes580B1405508-900 São PauloBrazil

The purpose of this paper is to classify wines from 4 different countries in South *** class of wines is formed by samples considered by experts as representatives of the following commercial categories:“Argentinean Malbec(AM)”,“Brazilian Merlot(BM)”,“Uruguayan Tannat(UT)”and“Chilean Carménère(CC)”.The 83 samples collected were analyzed according to their composition of volatiles,semi-volatiles and phenolic *** built a decision system for classification based on support vector machines(SVM),along with Correlation-based Feature selection(CFS),and RandomForest Importance(RFI),whichmeasures the relative importance of the input ***,we use CFS to select a subset of variables among 190 chemical *** chemicals were selected as correlated to the category and uncorrelated with each ***,these chemical compounds were organized according to the importance ranking given by the RFI and classified with *** study clearly indicated that SVMin combination with feature selection methodswas able to identify the most important chemicals to classify the wine *** the compounds identified in the wine samples,the variable subset defined by the feature selection methods,which were catechin,gallic,octanoic acid,myricetin,caffeic,isobutanol,resveratrol,kaempferol,and ORAC,were able to achieve an accuracy of 93.97%in classifying the commercial categories.

关键词： Wine classification Support vector machines Feature selection South American wines Machine learning

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Ergatoid reproductives in the Neotropical termite Nasutitermes aquilinus (Holmgren) (Blattaria: Isoptera: Termitidae): developmental origin, fecundity, and genetics

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Insect Science 2020年第6期27卷 1322-1333页

作者： Iago Bueno da Silva Ives Haifig Edward LVargo Fabiana Elaine Casarin Marcelo Luiz da Mota Juliana Toledo Lima Ana Maria costa-leonardo Laboratorio de Cupins Departamento de BiologiaInstituto de BiocienciasUniversidade Estadual Paulista-UN ESPRio ClaroSPBrazil Centro de Ciencias Naturais e Humanas Universidade Federal do ABCSao Bernardo do CampoSPBrazil Department of Entomology Texas A&M UniversityCollege StationTexasUSA Departamento de Ciencias Biologicas Universidade Federal de Sao Paulo-UNIFESPDiademaSPBrazil Instituto de Ciencias Agrarias Universidade Federal de Uberlandia—UFUMonte CarmeloMGBrazil Centro de Estudos em Recursos Naturais Universidade Estadual de Mato Grosso do SulDouradosMSBrazil

Termite colonies are usully headed by primary reproductives,which estab-listh nests during the swar ming ***,secondary reproductives may develop in some specics and become supplementary or replacement breeders,extending colony *** we investigate the developmental origin,fecundity and genetic characterizaion of ergatoid reproductives in the Neotropical termite Nasuitermes aquilinus(Holmgren),using morphometrical and histological techniques,five micosiallitle loci and the COI mitochondrial *** measurements performed on 208 apterous individuals of Nuauidius revealed 10 groups,including ergatoid females,which developed from major workers through two successive *** were characterized by the presence of imaginal features such as eyes andl wing *** difentiation of these features was correlated to physogastric development in these ergatoids,Histology revealed ooeytes in all matu-ration sages in worker-derived reproductives of N aquidinus,presence of nonflagellate spermatozoa inside the spermatheea,and royal fa ***,ergatoid reproduwetives were reproductively *** to the genotypes of 221 individuals from 11 nests,and mitochondrial haplotypes of 43 ergatoids,73%of the colomies were simple families,whereas 27%were extendbed *** the oecurenee of related reproductives,low inbreeding rates were detected within and among *** values could be explained given that sib mating itself cannot result in a higher inbreeding rate but depend on several factors discussed in *** is the first study to investigate the genetic structure of termite colonies influenced by the development of ergatoids and further investigations are encouraged 10 understand the inflwence of these reproductives on colony lifespan.

关键词： breeding syslem caste ifrentiation COI genotyping micosallites reproduction

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Unravelling the protracted U-Pb zircon geochronological record of high to ultrahigh temperature metamorphic rocks:Implications for provenance investigations

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Geoscience Frontiers 2023年第2期14卷 116-132页

作者： Mahyra Tedeschi Pedro leonardo Rossi Vieira Matheus Kuchenbecker Bruno VRibeiro Vitor Barrote Humberto Reis Laura Stutenbecker Cristiano Lana Antonio Pedrosa-Soares Ivo Dussin Programa de Pós-graduação em Geologia da Universidade Federal de Minerais Centro de Pesquisas Manoel Teixeira da CostaInstitute of GeosciencesFederal University of Minas GeraisAv.Antônio Carlos6627Belo Horizonte 31270-901Brazil Institute of Geological Sciences University of Bern3012 BernSwitzerland Laboratório de Estudos Tectônicos Universidade Federal dos Vales do Jequitinhonha e MucuriRodovia MGT 367Km 583-Diamantina 39100-000Brazil School of Earth Atmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6845Australia Freie Universität Berlin Institut für Geologische WissenschaftenGeochemieMalteserstr.1074-10012249 BerlinGermany Departamento de Geologia-Escola de Minas Universidade Federal de Ouro Preto 35400-000Brazil Department of Materials and Earth Sciences Institute of Applied GeosciencesTU DarmstadtSchnittspahnstr.964287 DarmstadtGermany TEKTOS Geotectonic Research Group Geology InstituteRio de Janeiro State UniversitySão Francisco Xavier Street524/4030-AMaracanãRio de Janeiro 20550-900Brazil

The assessment of detrital zircon age records is a key method in basin analysis,but it is prone to several biases that may compromise accurate sedimentary provenance *** to ultrahigh temperature(HT-UHT)metamorphism(especially if T>850℃)is herein presented as a natural cause of bias in provenance studies based on U-Pb detrital zircon ages,since zircon from rocks submitted to these extreme and often prolonged conditions frequently yield protracted,apparently concordant,geochronological *** age spreading can result from disturbance of the primary U-Pb zircon system,likewise from(re)crystallization processes during multiple and/or prolonged metamorphic *** this contribution,available geochronological data on Archean,Neoproterozoic and Palaeozoic HT-UHT metamorphic rocks,acquired by different techniques(SIMS and LA-ICP-MS)and showing distinct compositions,are reassessed to demonstrate HT-UHT metamorphism may result in modes and age distributions of unclear geological *** a consequence,it may induce misinterpretations on UPb detrital zircon provenance analyses,particularly in sedimentary rocks metamorphosed under such extreme temperature *** evaluate the presence of HT-UHT metamorphism-related bias in the detrital zircon record,we suggest a workflow for data acquisition and interpretation,combining a multi-proxy approach with:(i)in situ U-Pb dating coupled with Hf analyses to retrieve the isotopic composition of the sources,and(ii)the integration of a petrochronological investigation to typify fingerprints of the HT-UHT metamorphic *** proposed workflow is validated in the investigation of one theoretical and one natural example allowing a better characterization of the sedimentary sources,maximum depositional ages,and the tectonic setting of the *** workflow allows to the appraisal of biases imposed by HT-UHT metamorphism and resulting disturbances in the U-Pb detrital zircon record,particularly for sedimentary

关键词： Detrital zircon Protracted zircon record Sedimentary basins UHT metamorphism Prolonged metamorphism Bias in detrital zircon

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Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis

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World Journal of Gastroenterology 2012年第32期18卷 4278-4287页

作者： Rodrigo Goulart Pacheco Christiano costa Esposito Lucas CM Müller Morgana TL Castelo-Branco leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider Department of Surgery Experimental Surgery CenterSurgical Sciences Postgraduate ProgramMedical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Laboratory of Cellular Immunology Department of Histology and EmbryologyInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Pathology Medical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Internal Medicine Hospital Universitario Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil

AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion ***:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or *** were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical ***-up colonoscopy was performed every 4 wk for 12 *** effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent ***:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus *** with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal *** high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or ***:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis.

关键词：结肠炎丁酸引水实验炎症酶联免疫吸附试验纤维化谷氨酸

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