Distinct T helper cell-mediated antitumor immunity:T helper 2 cells in focus

作     者：Rafael Cardoso Maciel Costa Silva Marcela Freitas Lopes Leonardo Holanda Travassos Rafael Cardoso Maciel Costa Silva;Marcela Freitas Lopes;Leonardo Holanda Travassos

作者机构：Laboratory of Immunoreceptors and SignalingCarlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil Laboratory of Immunity Biology George DosReisCarlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil 

出 版 物：《Cancer Pathogenesis and Therapy》 (癌症发生与治疗（英文）)

年 卷 期：2023年第1卷第1期

页      面：76-86页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by Coordination for the Improvement of Higher Education Personnel(CAPES),Carlos Chagas Filho Foundation for Supporting Research in the State of Rio de Janeiro(grant number FAPERJ E−26/200.628/2022) National Counsel of Technological and Scientific Development(CNPq)Brazil 

主　　题：Cancer Immunology Adaptive immunity Immunotherapy Immunogenetics Antitumor immune response 

摘      要：The adaptive arm of the immune system is crucial for appropriate antitumor immune *** is generally accepted that clusters of differentiation 4^(+)(CD4^(+))T cells,which mediate T helper(Th)1 immunity(type 1 immunity),are the primary Th cell subtype associated with tumor *** this review,we discuss evidence showing that antitumor immunity and better prognosis can be associated with distinct Th cell subtypes in experimental mouse models and humans,with a focus on Th2 *** aim of this review is to provide an overview and understanding of the mechanisms associated with different tumor outcomes in the face of immune responses by focusing on the(1)site of tumor development,(2)tumor properties(i.e.,tumor metabolism and cytokine receptor expression),and(3)type of immune response that the tumor initially ***,we discuss how low-tolerance organs,such as lungs and brains,might benefit from a less tissue-destructive immune response mediated by Th2 *** addition,Th2 cells antitumor effects can be independent of CD8^(+)T cells,which would circumvent some of the immune escape mechanisms that tumor cells possess,like low expression of major histocompatibility-I(MHC-I).Finally,this review aims to stimulate further studies on the role of Th2 cells in antitumor immunity and briefly discusses emerging treatment options.