Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties
作者机构：Department of Biomedical EngineeringUniversity of Illinois ChicagoChicagoUSA Department of Prosthodontics and PeriodontologyPiracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and SurgeryDivision of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of PeriodonticsCenter for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical EngineeringUniversity of Illinois ChicagoChicagoUSA Department of Restorative DentistryUniversity of Illinois Chicago College of DentistryChicagoUSA
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2023年第30卷第12期
页 面：46-61页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程]
基 金：Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior-Brazil(CAPES),in the scope of Programa Capes-PrInt-Funding code:001″Process:88887.194785/2018-00 the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq,Brazil)(#309970/2022-9) L.P.F.V.A.R.B.received support from CNPq(Brazil)(#307471/2021-7) Sao Paulo Research Foundation(FAPESP,Brazil)(#2020/05231-4 and 2022/16267-5) R.C.C.received support from FAPESP(Brazil)(#2020/10436-4)
摘 要：Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improved ***,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.
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