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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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卵黄抗体咀嚼片配方优化及生物稳定性研究

中国食品添加剂 2023年第3期34卷 142-149页

作者：陆峙金郭蓉陈健伟周全张智李再新四川轻化工大学生物工程学院宜宾644000 富顺县人民医院消化内科自贡643200 四川科伦博泰生物医药股份有限公司成都610000

以卵黄抗体(immunoglobulin of yolk,IgY)、脱脂奶粉和硬脂酸镁等为原辅料混合直接压制成卵黄抗体咀嚼片。以硬度和感官评分为指标,通过单因素和正交试验确定IgY咀嚼片压制配方;体外探讨不同温度、pH、胃蛋白酶和胰蛋白酶处理对咀嚼片中... 详细信息

以卵黄抗体(immunoglobulin of yolk,IgY)、脱脂奶粉和硬脂酸镁等为原辅料混合直接压制成卵黄抗体咀嚼片。以硬度和感官评分为指标,通过单因素和正交试验确定IgY咀嚼片压制配方;体外探讨不同温度、pH、胃蛋白酶和胰蛋白酶处理对咀嚼片中IgY效价的影响并模拟胃肠道消化;通过灌喂小鼠,探究IgY咀嚼片的体内消化代谢。IgY咀嚼片最佳配方为脱脂奶粉45%、硬脂酸镁1.9%、矫味剂45%、微晶纤维素6.1%。IgY咀嚼片在60℃温度处理1 h,IgY咀嚼片抗体效价为阴性。在pH 4~8之间IgY咀嚼片效价稳定;在pH 1.2条件下处理3 h,抗体失活率53.63%;胃蛋白酶消化2 h,抗体失活率19%;胰蛋白酶消化3 h,抗体失活率91.03%。体外模拟胃肠道消化5 h,IgY咀嚼片无抗体活性。小鼠体内消化代谢高中剂量组,灌喂0.5~1 h,在胃、十二指肠内检测抗体效价阳性;灌喂3 h,在空肠中检测抗体效价阳性;灌喂6 h,在回肠中检测抗体效价阳性;灌喂12 h,在消化道内均检测抗体效价阴性。IgY咀嚼片适口性好,可以在消化道内保存一定的生物稳定性,为IgY的使用提供了新的思路。

关键词：卵黄抗体咀嚼片消化效价

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一个遗传性肾性尿崩症家系的基因诊断

中华医学遗传学杂志 2019年第2期36卷 140-142页

作者：陆之瑾吴霞周任远开凯闻杰熊茜复旦大学附属静安区中心医院上海200040

目的确定1个遗传性肾性尿崩症(hereditary nephrogenic diabetes insipidus,HNDI)家系的分子遗传学病因。方法采集家系中先证者和2例有类似症状的患者及2名正常成员的外周血样,提取DNA,经二代测序确定先证者的突变位点后,对家系中的... 详细信息

目的确定1个遗传性肾性尿崩症(hereditary nephrogenic diabetes insipidus,HNDI)家系的分子遗传学病因。方法采集家系中先证者和2例有类似症状的患者及2名正常成员的外周血样,提取DNA,经二代测序确定先证者的突变位点后,对家系中的类似患者及正常成员进行该位点的测序。结果先证者AVPR2基因存在c.856C>T半合子突变,2例类似症状及1名正常家系成员的AVPR2基因存在c.856C>T杂合突变。结论 AVPR2基因c.856C>T突变可能是导致该家系发生HNDI的原因。

关键词：遗传性肾性尿崩症 AVPR2基因突变

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卵黄抗体冻干粉除菌技术的研究

食品科技 2022年第2期47卷 118-123页

作者：徐婷吴洋赖小丹陆峙金陈建伟张智李再新四川轻化工大学生物工程学院四川宜宾644000

卵黄抗体(Immunoglobulin of yolk,IgY)是禽类经过特定抗原刺激产生的特异性免疫球蛋白,在生产过程中不能采用高温灭菌。为获得优质的IgY,利用微生物技术分析IgY冻干粉中的微生物,反复冻融和抗菌肽处理,ELISA技术测定IgY效价,抑菌圈法... 详细信息

卵黄抗体(Immunoglobulin of yolk,IgY)是禽类经过特定抗原刺激产生的特异性免疫球蛋白,在生产过程中不能采用高温灭菌。为获得优质的IgY,利用微生物技术分析IgY冻干粉中的微生物,反复冻融和抗菌肽处理,ELISA技术测定IgY效价,抑菌圈法、试管二倍稀释法和琼脂平板计数法测定抗菌肽对IgY冻干粉残留菌的影响。结果表明:IgY冻干粉中检测出残存沃氏葡萄球菌(***)和斐氏棒状杆菌(***);反复冻融4次,IgY冻干粉菌落总数随着冻融次数增加而显著下降(P0.05);抗菌肽浓度1.25 mg/mL时,IgY冻干粉菌落总数减少至0 cfu/g,且对IgY冻干粉效价影响无显著性差异(P>0.05)。由结果可以得出2种除菌方式有显著作用,但抗菌肽对IgY冻干粉除菌更简便,抑菌效果更显著,有益于生产上应用。

关键词：卵黄抗体冻干粉效价菌落总数杀菌抗菌肽

临床药师对冠心病合并高血压病患者的药学监护

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中国医院用药评价与分析 2017年第3期17卷 422-423,426页

作者：邝巧芬沈志杰卢志锦东莞市妇幼保健院药学部临床药学室广东东莞523112

目的:探讨临床药师在冠心病合并高血压病患者药学监护中的作用。方法:临床药师参与1例冠心病合并高血压病患者的药物治疗,协助临床医师为住院患者制订个体化治疗方案,并实施全程药学监护。结果:在冠心病合并高血压病患者的治疗中,临床... 详细信息

目的:探讨临床药师在冠心病合并高血压病患者药学监护中的作用。方法:临床药师参与1例冠心病合并高血压病患者的药物治疗,协助临床医师为住院患者制订个体化治疗方案,并实施全程药学监护。结果:在冠心病合并高血压病患者的治疗中,临床药师与临床医师密切合作,调整抗高血压药、抗血栓药等治疗方案,患者病情好转后出院。结论:临床药师开展以患者为中心的药学监护,有利于提高药学服务水平和服务质量,保障患者合理用药。

关键词：临床药师药学监护冠心病高血压病

社区可行的糖尿病周围神经病变检查方法的诊断价值

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上海医药 2015年第11期36卷 39-42页

作者：沈宇峰狄春明陆之瑾上海市静安区曹家渡街道社区卫生服务中心全科上海200042 上海市静安区中心医院内分泌科上海200040

目的 :探讨社区可行的糖尿病周围神经病变(DPN)的检查方法,对比这些检查方法在DPN中的诊断价值。方法 :对前来社区就诊符合条件的223例2型糖尿病患者进行神经缺陷评分(NDS)、密歇根神经病变筛选法检查(MNSI)、10 g尼龙单丝检查、震动感... 详细信息

目的 :探讨社区可行的糖尿病周围神经病变(DPN)的检查方法,对比这些检查方法在DPN中的诊断价值。方法 :对前来社区就诊符合条件的223例2型糖尿病患者进行神经缺陷评分(NDS)、密歇根神经病变筛选法检查(MNSI)、10 g尼龙单丝检查、震动感觉阈值检查(VPT)和肌电图(EMG)检查。以EMG作为"金标准",对比上述4种检查方法的敏感度、特异度、阳性预测值、阴性预测值、准确度以及k值。结果 :MNSI筛选法诊断DPN:MNSI>2.5分时其敏感度为92.11%、特异度为75.23%、阳性预测值为79.55%、阴性预测值为90.11%和准确度为59.19%[k值为(0.68±0.08)],与EMG检查之间呈高度一致;VPT检查诊断DPN:其敏感度为86.84%、特异度为76.15%,与EMG检查之间呈高度一致[k值为(0.63±0.03)];NDS评分诊断DPN:其敏感度为84.21%、特异度为61.47%、均低于MNSI筛选法和VPT检查,与EMG检查之间呈中度一致[k值为(0.46±0.05)];10 g尼龙丝检查结果显示,诊断DPN的敏感度、准确度及k值均较低,与EMG检查之间的一致性较差。结论 :MNSI筛选法(>2.5分)、VPT检查和NDS评分法简单、操作性好、可靠性好,易于推广,可用于社区门诊对糖尿病周围神经病变的初步筛查和流行病学调查。

关键词：糖尿病周围神经病变糖尿病 DPN检测

Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

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Nano Research 2025年第1期18卷 107-117页

作者： Wei Wang Weiqi Wang Huihui Wang Xing lu Jinwen Zhang Yunzhuo lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous

通窍活血汤辅以醒脑开窍针刺法联合微创血肿引流术治疗重症丘脑出血的效果分析

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中国当代医药 2023年第24期30卷 143-147页

作者：卢致金汤涛蒋满香郭世万江西省赣州市人民医院创伤急救中心创伤骨科江西赣州341000 江西省赣州市人民医院中医科江西赣州341000

目的探讨通窍活血汤辅以醒脑开窍针刺法联合微创血肿引流术治疗重症丘脑出血的效果。方法选取2020年3月至2022年12月赣州市人民医院收治的90例重症丘脑出血患者作为研究对象,按随机数字表法分为常规组和联合组,每组各45例。给予常规组... 详细信息

目的探讨通窍活血汤辅以醒脑开窍针刺法联合微创血肿引流术治疗重症丘脑出血的效果。方法选取2020年3月至2022年12月赣州市人民医院收治的90例重症丘脑出血患者作为研究对象,按随机数字表法分为常规组和联合组,每组各45例。给予常规组微创血肿引流术联合醒脑开窍针刺法治疗,联合组在常规组的基础上再增加通窍活血汤辅以治疗,两组均持续治疗14 d,比较两组治疗的总有效率、运动能力[Fugl-Meyer量表(FMA)]、脑损伤情况[S100钙结合蛋白B(S100B)、神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、血清转铁蛋白(TRF)]、院内情况及并发症发生情况。结果联合组治疗总有效率高于常规组,差异有统计学意义(P<0.05)。重复测量方差分析结果显示,两组患者的FMA评分及S100B、NSE、BDNF、TRF水平时间、组间、交互作用比较,差异有统计学意义(P<0.05)。两组患者治疗后7、14 d的FMA评分、BDNF水平均高于本组治疗前,S100B水平、NSE水平、TRF水平均低于本组治疗前,两组患者治疗后14 d的FMA评分、BDNF水平均高于治疗7 d,S100B水平、NSE水平、TRF水平均低于本组治疗7 d时,差异有统计学意义(P<0.05);联合组治疗7、14 d的FMA评分、BDNF水平均高于常规组,S100B水平、NSE水平、TRF水平均低于常规组,差异有统计学意义(P<0.05)。联合组患者引流管留置时间、ICU入住时间、意识恢复时间、出院时间均短于常规组,差异有统计学意义(P<0.05);联合组并发症总发生率低于常规组,差异有统计学意义(P<0.05)。结论重症丘脑出血微创术后予通窍活血汤、醒脑开窍针刺可以提高治疗有效率,加速运动能力恢复,减轻脑损伤,且安全性高。

关键词：通窍活血汤醒脑开窍针微创血肿引流术重症丘脑出血

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu Jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added