Zinc-prolinamide complex catalyzed direct asymmetric aldol reactions in the presence of water

作     者：LU ZhiJin MEI HaiBo ZHANG GuangQian HAN JianLin PAN Yi 

作者机构：School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China State Key Laboratory of Coordination ChemistryNanjing UniversityNanjing 210093China 

出 版 物：《Science China Chemistry》 (中国科学(化学英文版))

年 卷 期：2010年第53卷第11期

页      面：2291-2296页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

基　　金：the National Natural Science Foundation of China (20772056) Jiangsu 333 Program (for Pan) for the generous financial support The research funds for Pan from the Qing-Lan Program of Jiangsu Province the Kua-Shi-Ji Program of the Education Ministry of China 

主　　题：prolinamide Lewis acid aqueous media aldol reaction zinc 

摘      要：An efficient direct asymmetric aldol reaction with zinc triflate and prolinamides as combined catalysts is reported.A series of chiral prolinamides have been designed and used in the direct aldol reaction resulting in the desired products with excellent yields(up to 94% yield) and high enantioselectivities(up to 96% ee).Water was found to play a significant role in the formation of the aldol products,which suggests a new strategy in the design of new organic catalysts.