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Artificial intelligence models based on non-contrast chest CT for measuring bone mineral density

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中国医学影像技术 2024年第8期40卷 1231-1235页

作者： DUAN Wei YANG Guoqing li Yang SHI Feng YANG lian XIONG Xin CHEN Bei li yong FU Quanshui Department of Medical Imaging North Sichuan Medical CollegeNanchong 637000China Department of Radiology Suining Central HospitalSuining 629000China Department of Radiology Suining Hospital of Traditional Chinese MedicineSuining 629000China Shanghai United Imaging Intelligence Co.Ltd. Shanghai 201807China

Objective To observe the value of artificial intelligence(AI)models based on non-contrast chest CT for measuring bone mineral density(BMD).Methods Totally 380 subjects who underwent both non-contrast chest CT and quantitative CT(QCT)BMD examination were retrospectively enrolled and divided into training set(n=304)and test set(n=76)at a ratio of 8∶*** mean BMD of L1—L3 vertebrae were measured based on *** bones of T5—T10 vertebrae were segmented as ROI,radiomics(Rad)features were extracted,and machine learning(ML),Rad and deep learning(DL)models were constructed for classification of osteoporosis(OP)and evaluating BMD,*** operating characteristic curves were drawn,and area under the curves(AUC)were calculated to evaluate the efficacy of each model for classification of ***-Altman analysis and Pearson correlation analysis were performed to explore the consistency and correlation of each model with QCT for measuring *** Among ML and Rad models,ML Bagging-OP and Rad Bagging-OP had the best performances for classification of *** test set,AUC of ML Bagging-OP,Rad Bagging-OP and DL OP for classification of OP was 0.943,0.944 and 0.947,respectively,with no significant difference(all P>0.05).BMD obtained with all the above models had good consistency with those measured with QCT(most of the differences were within the range of Ax-G±1.96 s),which were highly positively correlated(r=0.910—0.974,all P<0.001).Conclusion AI models based on non-contrast chest CT had high efficacy for classification of OP,and good consistency of BMD measurements were found between AI models and QCT.

关键词： osteoporosis bone density tomography,X-ray computed artificial intelligence

Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning

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Nanomanufacturing and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov yong li Lukas Riedel Shan Shi Christian J.Cyron Roland C.Aydin Martin Ritter Institute for Continuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electron Microscopy Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physics and Technology Hamburg University of TechnologyHamburgGermany Institute of Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Group of Integrated Metallic Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of *** approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image ***,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current *** artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm *** study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of *** treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data.

关键词： Multimodal machine learning Multi-voltage images FIB-SEM Overdeterministic systems 3D reconstruction FIB tomography

TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen li-yong Zhu Zhi-Wei Cai Xiao Hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge Xiao-Yan Tang Chun-Jing li Yun-Long Pu Chong-Yi Jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang yong li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

Spatial transcriptomics:recent developments and insights in respiratory research

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Military Medical Research 2024年第3期11卷 430-448页

作者： Wen-Jia Wang liu-Xi Chu li-yong He Ming-Jing Zhang Kai-Tong Dang Chen Gao Qin-Yu Ge Zhou-Guang Wang Xiang-Wei Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035ZhejiangChina Orthopaedic Bioengineering Research Group Division of Surgery and Interventional ScienceUniversity College LondonLondon HA74LPUK

The respiratory system's complex cellular heterogeneity presents unique challenges to researchers in this *** bulk RNA sequencing and single-cell RNA sequencing(scRNA-seq)have provided insights into cell types and heterogeneity in the respiratory system,the relevant specific spatial localization and cellular interactions have not been clearly *** transcriptomics(ST)has filled this gap and has been widely used in respiratory *** review focuses on the latest iterative technology of ST in recent years,summarizing how ST can be applied to the physiological and pathological processes of the respiratory system,with emphasis on the ***,the current challenges and potential development directions are proposed,including high-throughput full-length transcriptome,integration of multi-omics,temporal and spatial omics,bioinformatics analysis,*** viewpoints are expected to advance the study of systematic mechanisms,including respiratory studies.

关键词： Spatial transcriptomics Lung Tumor Spatial multi-omics

Puerarin modulation of CENPA affects downstream PLK1 and CCNB1 expression to inhibit bladder cancer cell proliferation

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Traditional Medicine Research 2024年第9期9卷 32-41页

作者： Hao Xu Wen Gao Deng Pan Yu-Yang Ma Ruo-Ran Zhang yong-li Cao Yu-Chuan Zhou Ming-Yu Xu Pei-yong Zhang Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Cardiology The Fourth People’s Hospital of JinanJinan 250031China Graduate School Jiangsu UniversityZhenjiang 212013China Department of Urology The Peixian People’s HospitalXuzhou 221699China Department of Clinical Laboratory The First Affiliated Hospital of Harbin Medical UniversityHarbin 150006China

Background:The treatment alternatives for bladder cancer(BLCA),the 10th most prevalent cancer in the world,need to be further investigated,and many active substances like Puerarin in herbal medicine were found to be effective in treating *** purpose of this study was to investigate the potential treating mechanisms of Puerarin on ***:The cell counting kit 8 assay and flow cytometry were performed to confirm Puerarin’s ability to suppress *** differentially expressed proteins(DEPs)were obtained by Tandem Mass Tags technology and functional enrichment analysis performed by R *** most enriched pathways were selected for study and the DEPs were screened ***-protein interaction network maps were created using String and Cytoscape and key proteins,which will be analyzed for survival,expression,and upstream transcription factor prediction,were screened out using the cytoHubba ***3 was used to obtain upstream transcription factor validated by molecular docking and western blotting ***:Cell counting kit 8 showed that Puerarin inhibited BLCA cells,with 50%inhibitory concentration of 218μmol/L in T24 and 198μmol/L in *** cytometry reveals that Puerarin blocks T24 and 5637 cells in G1 phase.1,385 DEPs were obtained and the enrichment analysis revealed that cell cycle and DNA replication were the two main areas in which DEPs were ***-B-cyclin dependent kinase 1(CDK1),cyclin B1(CCNB1),and polo-like kinase 1(PLK1)were identified as key proteins,and their upstream transcription factor was predicted to be centromere protein A(CENPA).Puerarin’s binding energy to CENPA was determined by molecular docking to be−6.3 kcal/mol,indicating a strong binding *** blot showed that Puerarin significantly reduced the expression of ***:We hypothesize that Puerarin may inhibit the proliferation of bladder cancer cells by inhibiting CENPA expression to regulate PLK1 and CCNB1 expression,thereby a

关键词： Puerarin BLCA Tandem Mass Tags cell cycle

从“资本制”到“半殖民地半封建”——中国马克思主义史学家对近代中国社会性质的认知

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东岳论丛 2024年第1期45卷 143-154,192页

作者：李勇淮北师范大学史学理论与史学史研究中心安徽淮准北235000

中国马克思主义史学家,对近代中国社会性质的认识有“资本制”“殖民地化”“半殖民地”“半殖民地半封建”和“半封建半殖民地”诸说。“资本制”说与托派观点雷同,未能久立;“殖民地化”说是通用说法;“半殖民地”说是次通用提法;“... 详细信息

中国马克思主义史学家,对近代中国社会性质的认识有“资本制”“殖民地化”“半殖民地”“半殖民地半封建”和“半封建半殖民地”诸说。“资本制”说与托派观点雷同,未能久立;“殖民地化”说是通用说法;“半殖民地”说是次通用提法;“半殖民地”“半封建”组合顺序不同代表着人们对于外国帝国主义和国内封建势力的地位、影响之大小强弱的不同认识。共产国际内部意见不一,造成中共意见的模糊和分歧,导致中国马克思主义史学家异说纷呈。中国革命反帝反封建的理论和实践,逻辑上要求与之相匹配的是中国近代社会的“半殖民地半封建”说。有鉴于此,中国马克思主义史学家在抗战时期,特别是毛泽东发表《新民主主义论》之后,渐渐趋同“半殖民地半封建”说。然而,仍有主“半殖民地”和“半封建半殖民地”说者,体现了中国马克思主义史学阵营在“反帝反封建”主张前提下和而不同的学术气度。

关键词：中国马克思主义史学家近代中国 “资本制” “殖民地化” “半殖民地” “半封建”

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入觐与否：唐代节度使的朝觐及其历史演变

山西大学学报(哲学社会科学版) 2024年第2期47卷 100-109页

作者：李永福建师范大学社会历史学院

中国古代政权中，地方长官入京朝觐天子，具有申明君臣之义的重要政治意义。具体到唐代，地方长官的朝觐行为在唐前期由州郡代表朝集使承担，安史之乱以后则由藩镇长官节度使承担。与朝集使不同，唐代节度使的朝觐并无明确制度规定，但... 详细信息

中国古代政权中，地方长官入京朝觐天子，具有申明君臣之义的重要政治意义。具体到唐代，地方长官的朝觐行为在唐前期由州郡代表朝集使承担，安史之乱以后则由藩镇长官节度使承担。与朝集使不同，唐代节度使的朝觐并无明确制度规定，但“拜章请觐”是被大部分节度使遵守的一种政治规则。唐代节度使会出于罢职归朝、入朝为官、军功受赏、躲避祸乱、入京述职等原因请求朝觐。随着唐代中央与地方势力的此消彼长，节度使的朝觐在不同时期呈现出不同的内涵特征：唐肃宗至唐德宗时期表现为“不敢往，亦不敢叛”;唐宪宗至黄巢起义之前表现为“中外践更，出入跌用”;黄巢起义以后则表现为“称兵入朝，不由奏请”。唐代节度使的朝觐在这一过程中由恭顺之意异化为悖逆之举。

关键词：唐代节度使朝觐京城

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情理:文学经验介入知识生成的话语基础

中国文学批评 2024年第3期 152-162,192页

作者：李勇苏州大学文学院苏州215123

文学理论的知识生成不是理论内部的逻辑演绎,而是感性的文学经验介入理论话语所推动的知识创新。感性的文学经验介入理性的理论话语的方式是对话,对话的话语基础是情理。情理是一种文化中人们共享的一套认识世界、解释世界、感受世界的... 详细信息

文学理论的知识生成不是理论内部的逻辑演绎,而是感性的文学经验介入理论话语所推动的知识创新。感性的文学经验介入理性的理论话语的方式是对话,对话的话语基础是情理。情理是一种文化中人们共享的一套认识世界、解释世界、感受世界的智慧系统。文学用虚构与想象的方式、用诗性的语言来表达情理,理论用理性的论述来表达情理。因此,情理是感性的文学经验介入理论知识生成的话语基础。文学经验与理论话语共同遵守通情达理的话语规则,理论话语与文学经验对话的切入点是情感,并随着具体情境改变具体的对话方式。通过在常识中互相印证,以辩证思维进行互动,依据具体历史情境中的特定境遇展开对话,理论话语才能把情理讲通,合情合理的理论知识才能生成。

关键词：情理文学理论文学经验知识生成话语系统