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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

中华医学杂志(英文版) 2005年第20期000卷 5-11页

作者： lau tze kin,LEUNG Tak Yeung,FUNG Tak Yuen,Daljit S SAHOTA,LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China

Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedur

关键词： chorionic villus sampling · postoperative complication · pregnancy outcome

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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

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Chinese Medical Journal 2005年第20期118卷 1675-1681页

作者： lau tze kin LEUNG Tak Yeung FUNG Tak Yuen CHAN Lin Wai Daljit S SAHOTA LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spitalChinese University of Hong KongShatinHong Kong SARChina

Background The true risk of choronic villus sampling(CVS)is poorly *** objective of this study was to review the clinical outcome of transabdominal CVS performed in a university teaching unit,with an emphasis on the complication *** A comprehensive audit database was maintained for 1351 pregnant women,including 17 sets ot twin pregnancies,who had a *** and outcome of all CVSs made in the unit between May 1996 and May 2004 were *** CVSs were performed by one of 5 operators using the identical *** All procedures were performed transabdominally.A total of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 *** mean gestation at CVS was(11.8+0.7)weeks,and 97.3%of the procedures were performed between 11 and 13 completed *** majority(96.2%)required only 1 puncture to achieve correct needle *** procedure failed to obtain an adequate sample in 4 subjects(0.30%).A total of 1351 chromosomal studies were requested and there was 1 case(0.07%)of culture *** results of chromosomal studies were available within 14 days in 36.7%of the cases and within 21 days in 94.0%.Overall,77 chromosomal abnormalities(5.7%)and 5 cases of thalassemia major were *** outcome was unknown in only 13 singleton subjects(0.96%).In the remaining 1355 fetuses,there were 76 pregnancy terminations(5.56%),10 fetal losses with obvious obstetric causes(0.73%),and 21 potentially procedure-related fetal losses(1.54%).In the last group,the majority had one or more co-existing obstetric *** background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%.Therefore,the procedure-related fetal loss rate was estimated to be at the maximum of 0.74%.Conclusions In experienced hands,first trimester transabdominal CVS is an accurate and safe invasive prenatal diagnostic *** should be one of the treatment options available to pregn

关键词： chorionic villus sampling postoperative complication pregnancy outcome

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光谱核型分析联合微阵列比较基因组杂交诊断15号环状染色体综合征

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中华医学遗传学杂志 2012年第5期29卷 562-565页

作者：潘敏蔡光伟廖灿刘子健广州医学院附属广州市妇女儿童医疗中心产前诊断中心 510623 香港中文大学威尔斯亲王医院妇产科系

目的探讨联合应用光谱核型分析技术（spectral karyotyping，SKY）和微阵列比较基因组杂交技术（microarray-based comparative genomic hybridization，array-CGH）在诊断复杂疑难的环状染色体畸变中的价值。方法对1例常规G显带染色体... 详细信息

目的探讨联合应用光谱核型分析技术（spectral karyotyping，SKY）和微阵列比较基因组杂交技术（microarray-based comparative genomic hybridization，array-CGH）在诊断复杂疑难的环状染色体畸变中的价值。方法对1例常规G显带染色体核型分析疑诊为46，XY，r（15）？的8岁男性生长发育迟缓患儿依次应用SKY及array-CGH技术常规进行制片杂交，并通过相应的显微摄像系统和计算机软件分析结果。结果SKY技术明确了该患儿环状染色体来源于15号染色体，array-CGH技术明确患儿15q26．3末端存在约594kb的缺失，染色体基因位点编码范围为99689349—100282878。结论联合应用现代分子细胞遗传学技术可以从细胞到分子水平精确诊断复杂疑难的环状染色体病例，是常规染色体核型分析的有益补充，也有利于细胞遗传学向分子水平深入。

关键词： 15号环状染色体微阵列比较基因组杂交技术光谱核型分析技术

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胎儿镜下激光凝固胎盘吻合血管术治疗双胎输血综合征33例临床分析

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中华妇产科杂志 2012年第8期47卷 587-591页

作者：刘新秀刘子建王慧芳王秀美梁德杨福建医科大学附属第一医院超声影像科福州350005 香港领峰医务中心深圳市第二人民医院超声科香港中文大学威尔斯亲王医院妇产科学系

目的探讨胎儿镜下激光凝固胎盘吻合血管术（FLOc）治疗单绒毛膜双羊膜囊双胎（McDA）并发双胎输血综合征（TTTs）的临床效果。方法收集2003年11月-2010年12月香港中文大学威尔斯亲工医院妇产科学系胎儿医学组收治的来自内地的33例．TTT... 详细信息

目的探讨胎儿镜下激光凝固胎盘吻合血管术（FLOc）治疗单绒毛膜双羊膜囊双胎（McDA）并发双胎输血综合征（TTTs）的临床效果。方法收集2003年11月-2010年12月香港中文大学威尔斯亲工医院妇产科学系胎儿医学组收治的来自内地的33例．TTTS孕妇的临床资料，按Quintem分期标准进行分期，并分析实施FLOC时术中和术后的并发症，随访其妊娠结局及胎儿存活情况。结果（1）FLOC时孕周及Quintero分期：33例TTTS孕妇的平均年龄为30岁，行FLOC时孕周中位数是23周＋4，按Quinter0分期I期3例，Ⅱ期14例，Ⅲ期7例，Ⅳ期9例。其中I期的手术指征为受血胎儿出现非常严重的心功能不全1例和重度羊水过多2例。（2）并发症：术中并发症5例，其中穿刺点宫腔内出血4例，较大的胎盘吻合血管破裂出血1例；术后并发症6例，其中术后1周内流产2例，1周内1个胎儿宫内死产1例，术后2～4周流产2例，术后2～4周发生羊膜带综合征1例。（3）妊娠结局及胎儿存活率：33例孕妇行FLOC治疗至分娩的间隔时间中位数为9周“；分娩孕周中位数为31周”；分娩孕周〈24周者为6％（2／33），24～28周者为21％（7／33），28—32周者为18％（6／33），32～37周者为55％（18／33）。出生体质量供血胎为1600g（350～2520g），受血胎为1930g（400～3040g）；胎儿整体存活率为59％（39／66），双胎存活率为52％（17／，33），单胎存活率为15％（5／33），至少1胎存活率为67％（22／33）。整体胎儿存活率从Quintem分期Ⅱ期的61％（17／28）下降到Ⅳ期的9／18。结论FLOC治疗MCDA并发TTTS的临床效果良好，可将胎儿整体存活率提升到接近60％，至少1胎存活率则更高，且严重并发症少；TTTs孕妇的妊娠结局除与Quintero期别有关外，还与FLOC后严密监测和管理、适时终止妊娠有关。

关键词：双胎输血综合征胎儿镜检查激光凝固术血管外科手术

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昆明地区妊娠早期正常单胎胎儿颈部透明层厚度的分布及参考值范围

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中华妇产科杂志 2012年第7期47卷 514-517页

作者：孙倩许静胡顺琴陈敏马润玫刘子建张兰肖雪钱源郭知昆明医学院第一附属医院妇产科昆明650032 香港中文大学妇产科学系胎儿医学中心

目的调查昆明地区妊娠早期正常单胎胎儿颈部透明层（NT）厚度的分布情况，制定本地区NT厚度的参考值范围。方法以2009--2010年在昆明医学院第一附属医院就诊的妊娠早期（孕11～13周^＋6）单胎孕妇共1790例为观察对象，参照英国胎儿基金... 详细信息

目的调查昆明地区妊娠早期正常单胎胎儿颈部透明层（NT）厚度的分布情况，制定本地区NT厚度的参考值范围。方法以2009--2010年在昆明医学院第一附属医院就诊的妊娠早期（孕11～13周^＋6）单胎孕妇共1790例为观察对象，参照英国胎儿基金会（FMF）的标准超声测量胎儿头臀径（CRL）及NT厚度，并随访妊娠结局，对确认为正常胎儿的上述测量值通过简单线性回归分析CRL与NT厚度的相关性，制定本地区妊娠早期正常单胎胎儿NT厚度的参考值范围。结果最终纳入本研究的1790例正常单胎胎儿的CRL均数为（59．6±9．2）mm，中位数为58．3mm，NT厚度均数为（1.7±0．5）mm，中位数为1．7mm。不同CRL范围内NT厚度的参考值范围不同，胎儿CRL在45．0～54．9mm、55.0～64.9mm、65．0～74.9mm、75.0～84．0mm范围时，相应的NT厚度测量值第5～95百分位数分别为1．0—2．0mm、103～2．5mm、1.5～2．7mm、1.5～2．9mm，中位数分别为1．4、1．7、2．0、2．0mm。胎儿NT厚度测量值与孕妇年龄无显著相关性（P〉0．05）；男胎NT厚度测量值的均数为（1．84-1．1）mm，女胎为（1．74-0．6）mm，两者比较，差异有统计学意义（P=0．001）。结论本研究初步制定出昆明地区妊娠早期正常单胎胎儿不同CRL相对应的NT厚度参考值范围，为产前筛查的进一步实施提供了参考依据。

关键词：颈部透明带检查超声检查产前妊娠初期参考值

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Intra- and Inter-Observer Reproducibility of Ultrasound Measurements of Pelvic Inlet Diameter in Pregnant Women

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Open Journal of Obstetrics and Gynecology 2014年第11期4卷 653-658页

作者： Yi Man Wah Yiu Man Chan Daljit Singh Sahota Shuk Yi Hui tze kin lau Tak Yeung Leung Department of Obstetrics and Gynecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China

Objectives: To determine intra- and inter-observer reproducibility of the ultrasound measurement of pelvic inlet in the first trimester of pregnancy. Methods: Transabdominal pelvic ultrasound was performed to measure the pelvic inlet anteroposterior diameter using a 2D probe in twelve Chinese women having a singleton pregnancy. Scans were performed in the first trimester by three sonographers. The pelvic inlet anteroposterior diameter was defined as the distance between the anterior surfaces of the sacral promontory and the superior medial border of the pubic bone most adjacent to the pubic symphysis. Intra-observer repeatability was determined and analysis of variance was performed to assess inter-observer measurements. The bias between any two sonographers’ measurements was assessed by calculating the 95% confidence interval for the mean difference between sonographers paired measurements. Results: Intra-observer reproducibility was 0.71 cm. Analysis of variance indicated that there was no significant difference between sonographers’ measurements (p = 0.46). The bias between two sonographers’ measurements ranged from 0.05 to 0.32 cm. Conclusion: It is technically feasible to measure the pelvic inlet diameter using ultrasound (USG) at the first trimester. High inter-observer reproducibility can be achieved. Further studies are required to establish the potential role of this technique and the measurement of the pelvic inlet diameter in prediction of labor outcome.

关键词： Pelvimetry Pelvic Inlet Diameter Obstetric Conjugate

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基于ASCP-CS算法的桥式吊车滑模控制器设计

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湖南大学学报（自然科学版） 2020年第6期47卷 87-95页

作者：王天雷谭南林张人丰邱炯智 Kenneth Teo tze kin 北京交通大学机械与电子控制工程学院北京100044 五邑大学智能制造学部广东江门529020 沙巴大学工程学院马来西亚沙巴哥打基纳巴卢

针对桥式吊车滑模控制器参数设置繁琐以及布谷鸟搜索算法(Cuckoo Search,CS)全局搜索能力不足问题,提出了自适应选取交叉操作算子的布谷鸟搜索算法(Cuckoo Search Algorithm with Adaptively Selecting Crossover Points,ASCP-CS),并将... 详细信息

针对桥式吊车滑模控制器参数设置繁琐以及布谷鸟搜索算法(Cuckoo Search,CS)全局搜索能力不足问题,提出了自适应选取交叉操作算子的布谷鸟搜索算法(Cuckoo Search Algorithm with Adaptively Selecting Crossover Points,ASCP-CS),并将该算法用于桥式吊车滑模控制器参数整定.该算法在CS算法的基础上改进自适应搜索步长,并在交叉操作过程中引入自适应选取染色体交叉点.通过对4种典型寻优函数进行测试的结果表明:ASCP-CS算法具有较好的寻优精度和搜索能力.对桥式吊车滑模控制器采用不同优化算法进行参数整定,仿真实验表明,基于该算法的控制器能更快地实现吊车负载定位,更有效抑制负载摆角,并具有较好的鲁棒性.

关键词：桥式吊车布谷鸟搜索自适应步长滑模控制器非线性系统

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Bis（7）-tacrine attenuates Ap25-35-induced apoptosis in rat cortical neurons via regulating calcium homeostasis

Bis（7）-tacrine attenuates Ap25-35-induced apoptosis in rat...

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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Nelson tze-kin Lee Donald C. Chang Department of Biochemistry Hong Kong University of Science and Technology Department of Biology Hong Kong University of Science and Technology

＜正＞Although the exact mechanism of Alzheimer disease （AD） is not illustrated, the neurotoxicity of amyloid β-protein （Aβ） has been suggested as the core event for the disease. Apoptosis is mainly implicated in the pathological role of Aβin AD. Currently, four acetylcholinesterase （AChE） inhibitors and one antagonist of NMDA receptor （memantine） are the only two categories of drugs approved by the United States for the treatment of AD. However, the AChE inhibitors can only attenuate the memory

关键词： AChE inhibitors Bis(7)-tacrine amyloid beta peptide Alzheimer disease calcium homeostasis

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