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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

中华医学杂志(英文版) 2005年第20期000卷 5-11页

作者： lau tze kin,LEUNG Tak Yeung,FUNG Tak Yuen,Daljit S SAHOTA,LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China

Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedur

关键词： chorionic villus sampling · postoperative complication · pregnancy outcome

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Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

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Chinese Medical Journal 2005年第20期118卷 1675-1681页

作者： lau tze kin LEUNG Tak Yeung FUNG Tak Yuen CHAN Lin Wai Daljit S SAHOTA LEUNG Tse Ngong Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spitalChinese University of Hong KongShatinHong Kong SARChina

Background The true risk of choronic villus sampling(CVS)is poorly *** objective of this study was to review the clinical outcome of transabdominal CVS performed in a university teaching unit,with an emphasis on the complication *** A comprehensive audit database was maintained for 1351 pregnant women,including 17 sets ot twin pregnancies,who had a *** and outcome of all CVSs made in the unit between May 1996 and May 2004 were *** CVSs were performed by one of 5 operators using the identical *** All procedures were performed transabdominally.A total of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 *** mean gestation at CVS was(11.8+0.7)weeks,and 97.3%of the procedures were performed between 11 and 13 completed *** majority(96.2%)required only 1 puncture to achieve correct needle *** procedure failed to obtain an adequate sample in 4 subjects(0.30%).A total of 1351 chromosomal studies were requested and there was 1 case(0.07%)of culture *** results of chromosomal studies were available within 14 days in 36.7%of the cases and within 21 days in 94.0%.Overall,77 chromosomal abnormalities(5.7%)and 5 cases of thalassemia major were *** outcome was unknown in only 13 singleton subjects(0.96%).In the remaining 1355 fetuses,there were 76 pregnancy terminations(5.56%),10 fetal losses with obvious obstetric causes(0.73%),and 21 potentially procedure-related fetal losses(1.54%).In the last group,the majority had one or more co-existing obstetric *** background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%.Therefore,the procedure-related fetal loss rate was estimated to be at the maximum of 0.74%.Conclusions In experienced hands,first trimester transabdominal CVS is an accurate and safe invasive prenatal diagnostic *** should be one of the treatment options available to pregn

关键词： chorionic villus sampling postoperative complication pregnancy outcome

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光谱核型分析联合微阵列比较基因组杂交诊断15号环状染色体综合征

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中华医学遗传学杂志 2012年第5期29卷 562-565页

作者：潘敏蔡光伟廖灿刘子健广州医学院附属广州市妇女儿童医疗中心产前诊断中心 510623 香港中文大学威尔斯亲王医院妇产科系

目的探讨联合应用光谱核型分析技术（spectral karyotyping，SKY）和微阵列比较基因组杂交技术（microarray-based comparative genomic hybridization，array-CGH）在诊断复杂疑难的环状染色体畸变中的价值。方法对1例常规G显带染色体... 详细信息

目的探讨联合应用光谱核型分析技术（spectral karyotyping，SKY）和微阵列比较基因组杂交技术（microarray-based comparative genomic hybridization，array-CGH）在诊断复杂疑难的环状染色体畸变中的价值。方法对1例常规G显带染色体核型分析疑诊为46，XY，r（15）？的8岁男性生长发育迟缓患儿依次应用SKY及array-CGH技术常规进行制片杂交，并通过相应的显微摄像系统和计算机软件分析结果。结果SKY技术明确了该患儿环状染色体来源于15号染色体，array-CGH技术明确患儿15q26．3末端存在约594kb的缺失，染色体基因位点编码范围为99689349—100282878。结论联合应用现代分子细胞遗传学技术可以从细胞到分子水平精确诊断复杂疑难的环状染色体病例，是常规染色体核型分析的有益补充，也有利于细胞遗传学向分子水平深入。

关键词： 15号环状染色体微阵列比较基因组杂交技术光谱核型分析技术

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Intra- and Inter-Observer Reproducibility of Ultrasound Measurements of Pelvic Inlet Diameter in Pregnant Women

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Open Journal of Obstetrics and Gynecology 2014年第11期4卷 653-658页

作者： Yi Man Wah Yiu Man Chan Daljit Singh Sahota Shuk Yi Hui tze kin lau Tak Yeung Leung Department of Obstetrics and Gynecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China

Objectives: To determine intra- and inter-observer reproducibility of the ultrasound measurement of pelvic inlet in the first trimester of pregnancy. Methods: Transabdominal pelvic ultrasound was performed to measure the pelvic inlet anteroposterior diameter using a 2D probe in twelve Chinese women having a singleton pregnancy. Scans were performed in the first trimester by three sonographers. The pelvic inlet anteroposterior diameter was defined as the distance between the anterior surfaces of the sacral promontory and the superior medial border of the pubic bone most adjacent to the pubic symphysis. Intra-observer repeatability was determined and analysis of variance was performed to assess inter-observer measurements. The bias between any two sonographers’ measurements was assessed by calculating the 95% confidence interval for the mean difference between sonographers paired measurements. Results: Intra-observer reproducibility was 0.71 cm. Analysis of variance indicated that there was no significant difference between sonographers’ measurements (p = 0.46). The bias between two sonographers’ measurements ranged from 0.05 to 0.32 cm. Conclusion: It is technically feasible to measure the pelvic inlet diameter using ultrasound (USG) at the first trimester. High inter-observer reproducibility can be achieved. Further studies are required to establish the potential role of this technique and the measurement of the pelvic inlet diameter in prediction of labor outcome.

关键词： Pelvimetry Pelvic Inlet Diameter Obstetric Conjugate

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基于ASCP-CS算法的桥式吊车滑模控制器设计

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湖南大学学报（自然科学版） 2020年第6期47卷 87-95页

作者：王天雷谭南林张人丰邱炯智 Kenneth Teo tze kin 北京交通大学机械与电子控制工程学院北京100044 五邑大学智能制造学部广东江门529020 沙巴大学工程学院马来西亚沙巴哥打基纳巴卢

针对桥式吊车滑模控制器参数设置繁琐以及布谷鸟搜索算法(Cuckoo Search,CS)全局搜索能力不足问题,提出了自适应选取交叉操作算子的布谷鸟搜索算法(Cuckoo Search Algorithm with Adaptively Selecting Crossover Points,ASCP-CS),并将... 详细信息

针对桥式吊车滑模控制器参数设置繁琐以及布谷鸟搜索算法(Cuckoo Search,CS)全局搜索能力不足问题,提出了自适应选取交叉操作算子的布谷鸟搜索算法(Cuckoo Search Algorithm with Adaptively Selecting Crossover Points,ASCP-CS),并将该算法用于桥式吊车滑模控制器参数整定.该算法在CS算法的基础上改进自适应搜索步长,并在交叉操作过程中引入自适应选取染色体交叉点.通过对4种典型寻优函数进行测试的结果表明:ASCP-CS算法具有较好的寻优精度和搜索能力.对桥式吊车滑模控制器采用不同优化算法进行参数整定,仿真实验表明,基于该算法的控制器能更快地实现吊车负载定位,更有效抑制负载摆角,并具有较好的鲁棒性.

关键词：桥式吊车布谷鸟搜索自适应步长滑模控制器非线性系统

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Bis（7）-tacrine attenuates Ap25-35-induced apoptosis in rat cortical neurons via regulating calcium homeostasis

Bis（7）-tacrine attenuates Ap25-35-induced apoptosis in rat...

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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Nelson tze-kin Lee Donald C. Chang Department of Biochemistry Hong Kong University of Science and Technology Department of Biology Hong Kong University of Science and Technology

＜正＞Although the exact mechanism of Alzheimer disease （AD） is not illustrated, the neurotoxicity of amyloid β-protein （Aβ） has been suggested as the core event for the disease. Apoptosis is mainly implicated in the pathological role of Aβin AD. Currently, four acetylcholinesterase （AChE） inhibitors and one antagonist of NMDA receptor （memantine） are the only two categories of drugs approved by the United States for the treatment of AD. However, the AChE inhibitors can only attenuate the memory

关键词： AChE inhibitors Bis(7)-tacrine amyloid beta peptide Alzheimer disease calcium homeostasis

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单绒毛膜双胎妊娠的围产结局分析

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中华妇产科杂志 2013年第6期48卷 405-410页

作者：余海燕刘子建 DaljitS.Sahota 丁婉霞梁德杨香港中文大学威尔斯亲王医院妇产科香港领峰医务中心产前诊断中心

目的探讨单绒毛膜（MC）双胎妊娠的围产结局。方法2005年1月—2010年12月在香港中文大学威尔斯亲王医院产前检查并分娩的MC双胎妊娠孕妇197例，分为无并发症组（136例）、双胎输血综合征（1TIYI、s）组（32例）及选择性宫内生长受限（sl... 详细信息

目的探讨单绒毛膜（MC）双胎妊娠的围产结局。方法2005年1月—2010年12月在香港中文大学威尔斯亲王医院产前检查并分娩的MC双胎妊娠孕妇197例，分为无并发症组（136例）、双胎输血综合征（1TIYI、s）组（32例）及选择性宫内生长受限（slUGR）组（29例），对各组孕妇的基本资料、产科并发症、胎儿超声检查结果及围产结局进行分析与比较。结果（1）分娩孕周及活产儿数：1耵s组、slUGR组孕妇分娩孕周（分别为孕30周、34周）及活产儿数（分别为36、47例）均显著低于无并发症组（分别为孕37周、261例），差异均有统计学意义（P〈0．01）。（2）死胎：rIT兀s组、slUGR组死胎发生率[分别为34％（11／32）、28％（8／29）]均显著高于无并发症组[4％（6／136）]，分别比较，差异均有统计学意义（P〈0．01）。（3）双胎出生体质量差异〉25％：‘ITrrs组、slUGR组双胎儿出生体质量差异〉25％的发生率[分别为5／15、33％（7／21）]均显著高于无并发症组[7．7％（10／130）]，分别比较，差异均有统计学意义（P〈0．05）。（4）早产：slUGR组早产发生率[69％（20／29）]显著高于无并发症组[49％（66／136）]，差异有统计学意义（P〈0．05）。（5）围产儿死亡：无并发症组、1_ITrS组、slUGR组围产儿死亡分别为1例（0．4％，1／262）、5例（12％，5／41）、5例（10％，5／52），1TI髑组及slUGR组围产儿死亡率均显著高于无并发症组，差异均有统计学意义（P〈0．01）。（6）双胎儿估计体质量（EFW）差异〉25％：无并发症组23例（17％，23／136），sIUGR组15例（52％，15／29），1_I’I’s组20例（63％，20／32），slUGR组及‘兀Trs组双胎EFW差异〉25％发生率明显高于无并发症组。无并发症组、slUGR组中EFW差异〉25％者分娩孕周均明显低于同组中EFW差异≤25％者（P〈0．05），两组中EFW差异〉25％时早产率、新生儿ICU（NICU）入住率均显著高于同组中EFW差异≤25％者（P〈0．05），无并发症组EFW差异〉25％时新生儿窒息率显著升高（P〈0．05）。（7）脐动脉血流多普勒监测异常：无并发症组13例（9．6％，13／136）发生异常，1YIvI’S组12例（38％，12／32）异常，slUGR组12例（41％，12／29）异常，1TITs组、slUGR组脐动脉血流异常发生率明显高于无并发症组，差异均有统计学意义（P〈0．01）。脐动脉血流异常者死胎发生率在无并发症组、r丌Ts组、slUGR组分别为2／13、6／12、5／12。结论MC双胎并发1TITs、slUGR者不良围产结局发生率高于无并发症MC双胎；双胎儿EFW差异〉25％者不良围产结局发生率增加；脐动脉血流多普勒监测异常与MC双胎妊娠结局相关。

关键词：双生,单绒毛膜双胎输血综合征胎儿生长受限出生体重妊娠结局

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