Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

作     者：LAU Tze Kin,LEUNG Tak Yeung,FUNG Tak Yuen,Daljit S SAHOTA,LEUNG Tse Ngong 

作者机构：Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China Fetal Medicine Unit Department of Obstetrics and Gynaecology Prince of Wales Ho spital Chinese University of Hong Kong Shatin Hong Kong SAR China 

出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)

年 卷 期：2005年第20期

页      面：5-11页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：chorionic villus sampling · postoperative complication · pregnancy outcome 

摘      要：Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedur