Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients

作     者：LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen CHAN Lin Wai Daljit S SAHOTA LEUNG Tse Ngong 

作者机构：Fetal Medicine UnitDepartment of Obstetrics and Gynaecology Prince of Wales Ho spitalChinese University of Hong KongShatinHong Kong SARChina 

出 版 物：《Chinese Medical Journal》 (中华医学杂志(英文版))

年 卷 期：2005年第118卷第20期

页      面：1675-1681页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：chorionic villus sampling postoperative complication pregnancy outcome 

摘      要：Background The true risk of choronic villus sampling(CVS)is poorly *** objective of this study was to review the clinical outcome of transabdominal CVS performed in a university teaching unit,with an emphasis on the complication *** A comprehensive audit database was maintained for 1351 pregnant women,including 17 sets ot twin pregnancies,who had a *** and outcome of all CVSs made in the unit between May 1996 and May 2004 were *** CVSs were performed by one of 5 operators using the identical *** All procedures were performed transabdominally.A total of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 *** mean gestation at CVS was(11.8+0.7)weeks,and 97.3%of the procedures were performed between 11 and 13 completed *** majority(96.2%)required only 1 puncture to achieve correct needle *** procedure failed to obtain an adequate sample in 4 subjects(0.30%).A total of 1351 chromosomal studies were requested and there was 1 case(0.07%)of culture *** results of chromosomal studies were available within 14 days in 36.7%of the cases and within 21 days in 94.0%.Overall,77 chromosomal abnormalities(5.7%)and 5 cases of thalassemia major were *** outcome was unknown in only 13 singleton subjects(0.96%).In the remaining 1355 fetuses,there were 76 pregnancy terminations(5.56%),10 fetal losses with obvious obstetric causes(0.73%),and 21 potentially procedure-related fetal losses(1.54%).In the last group,the majority had one or more co-existing obstetric *** background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%.Therefore,the procedure-related fetal loss rate was estimated to be at the maximum of 0.74%.Conclusions In experienced hands,first trimester transabdominal CVS is an accurate and safe invasive prenatal diagnostic *** should be one of the treatment options available to pregn