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Acidic Magnetic Biocarbon-Enabled Upgrading of Biomass-Based Hexanedione into Pyrroles

Journal of Renewable Materials 2023年第11期11卷 3847-3865页

作者： Zhimei Li kuan tian Keping Wang Zhengyi Li Haoli Qin Hu Li School of Chemistry and Materials Science Guizhou Normal UniversityGuiyang550001China National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang550025China

Sustainable acquisition of bioactive compounds from biomass-based platform molecules is a green alternative for existing CO_(2)-emitting fossil-fuel technologies.Herein,a core–shell magnetic biocarbon catalyst functionalized with sulfonic acid(Fe3O4@SiO_(2)@chitosan-SO_(3)H,MBC-SO_(3)H)was prepared to be efficient for the synthesis of various N-substituted pyrroles(up to 99% yield)from bio-based hexanedione and amines under mild conditions.The abundance of Bronsted acid sites in the MBC-SO_(3)H ensured smooth condensation of 2,5-hexanedione with a variety of amines to produce N-substituted pyrroles.The reaction was illustrated to follow the conventional Pall-Knorr coupling pathway,which includes three cascade reaction steps:amination,loop closure and dehydration.The prepared MBC-SO_(3)H catalyst could effectively activate 2,5-hexanedione,thus weakening the dependence of the overall conversion process on the amine nucleophilicity.The influence of different factors(e.g.,reaction temperature,time,amount of catalyst,molar ratio of substrates,and solvent type)on the reaction activity and selectivity were investigated comprehensively.Moreover,the MBC-SO_(3)H possessed excellent thermochemical stability,reusability,and easy separation due to the presence of magnetic core-shell structures.Notably,there was no activity attenuation after 5 consecutive catalytic experiments.This work demonstrates a wide range of potential applications of developing functionalized core-shell magnetic materials to construct bioactive backbones from biomass-based platform molecules.

关键词： Magnetic materials biomass conversion heterogeneous catalysis sustainable chemistry

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Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas

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Protein & Cell 2023年第2期14卷 105-122页

作者： Fangyu Wang Xuan Liu Shaowen Li Chen Zhao Yumei Sun kuan tian Junbao Wang Wei Li Lichao Xu Jing Jing Juan Wang Sylvia MEvans Zhiqiang Li Ying Liu Yan Zhou Department of Neurosurgery Zhongnan hospital of Wuhan UniversityFrontier Science Center for Immunology and MetabolismMedical Research InstituteThe RNA InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China Department of Neurology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Skaggs School of Pharmacy Department of MedicineDepartment of PharmacologyUniversity of California at San DiegoLa JollaCA 92093USA

Glioblastoma multiforme(GBM),a highly malignant and heterogeneous brain tumor,contains various types of tumor and non-tumor cells.Whether GBM cells can trans-differentiate into non-neural cell types,including mural cells or endothelial cells(ECs),to support tumor growth and invasion remains controversial.Here we generated two genetic GBM models de novo in immunocompetent mouse brains,mimicking essential pathological and molecular features of human GBMs.Lineage-tracing and transplantation studies demonstrated that,although blood vessels in GBM brains underwent drastic remodeling,evidence of trans-differentiation of GBM cells into vascular cells was barely detected.Intriguingly,GBM cells could promiscuously express markers for mural cells during gliomagenesis.Furthermore,single-cell RNA sequencing showed that patterns of copy number variations(CNVs)of mural cells and ECs were distinct from those of GBM cells,indicating discrete origins of GBM cells and vascular components.Importantly,single-cell CNV analysis of human GBM specimens also suggested that GBM cells and vascular cells are likely separate lineages.Rather than expansion owing to trans-differentiation,vascular cell expanded by proliferation during tumorigenesis.Therefore,cross-lineage trans-differentiation of GBM cells is very unlikely to occur during gliomagenesis.Our findings advance understanding of cell lineage dynamics during gliomagenesis,and have implications for targeted treatment of GBMs.

关键词： glioblastoma mural cells endothelial cells trans-differentiation lineage tracing single-cell sequencing copy number variation

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Transcriptome Analysis Identifies SenZfp536,a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors

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Neuroscience Bulletin 2021年第2期37卷 183-200页

作者： kuan tian Andi Wang Junbao Wang Wei Li Wenchen Shen Yamu Li Zhiyuan Luo Ying Liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430072China Frontier Science Center for Immunology and Metabolism Medical Research InstituteSchool of MedicineWuhan UniversityWuhan430071China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Long non-coding RNAs(lncRNAs)regulate transcription to control development and homeostasis in a variety of tissues and organs.However,their roles in the development of the cerebral cortex have not been well elucidated.Here,a bioinformatics pipeline was applied to delineate the dynamic expression and potential cis-regulating effects of mouse lncRNAs using transcriptome data from 8 embryonic time points and sub-regions of the developing cerebral cortex.We further characterized a sense lncRNA,SenZfp536,which is transcribed downstream of and partially overlaps with the protein-coding gene Zfp536.Both SenZfp536 and Zfp536 were predominantly expressed in the proliferative zone of the developing cortex.Zfp536 was cis-regulated by SenZfp536,which facilitates looping between the promoter of Zfp536 and the genomic region that transcribes SenZfp536.Surprisingly,knocking down or activating the expression of SenZfp536 increased or compromised the proliferation of cortical neural progenitor cells(NPCs),respectively.Finally,overexpressing Zfp536 in cortical NPCs reversed the enhanced proliferation of cortical NPCs caused by SenZfp536 knockdown.The study deepens our understanding of how lncRNAs regulate the propagation of cortical NPCs through cis-regulatory mechanisms.

关键词： Zfp536 Sense lncRNA Self-renewal Cortical development Neural progenitor

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Cr_(2)O_(3)对ZnO-Bi_(2)O_(3)基高压压敏陶瓷性能的影响

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材料工程 2024年第4期52卷 54-60页

作者：桂阳海涂远生田宽郭会师黄海张心华郑州轻工业大学材料与化学工程学院郑州450000 南阳金牛电气有限公司河南南阳473000 河南恒安电力股份有限公司郑州450001

采用固相烧结法制备ZnO-Bi_(2)O_(3)-Co_(2)O_(3)-NiO-Mn_(3)O_(4)-SiO_(2)-Cr_(2)O_(3)压敏陶瓷,研究不同掺杂量的Cr_(2)O_(3)对ZnO压敏陶瓷的微观结构和电气性能的影响。通过X射线衍射仪(XRD)、场发射扫描电子显微镜(FESEM)及电化学工作站分别对样品的物相、微观形貌及电性能进行表征。结果表明:Cr_(2)O_(3)的加入不仅具有抑制ZnO晶粒异常生长和提升晶粒均匀分布的作用,而且能显著降低ZnO晶粒电阻,增加晶界电阻。在Cr_(2)O_(3)添加量为0%~0.21%(摩尔分数,下同)范围内,随着添加量的增大,压敏陶瓷的非线性系数表现为先增加后减小。当Cr_(2)O_(3)掺杂量为0.14%时,ZnO压敏陶瓷具有优异的电气性能:电位梯度E_(1 mA)=216 V·mm^(-1)、泄漏电流J_L=0.36μA·cm^(-2)、非线性系数α=25、残压比K=1.815、老化系数K_(ct)=0.647。此外,该压敏陶瓷在4/10μs波形下100 kA脉冲电流冲击2次后U_(1 mA)仍保持为初始的96.75%,表现出良好的冲击稳定性,在配电系统避雷器中具有巨大的应用潜力。

关键词： ZnO压敏陶瓷 Cr_(2)O_(3)掺杂微观结构电气性能阻抗性能

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Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3)纳米材料制备及H_(2)S气敏性能

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复合材料学报 2024年第2期41卷 816-826页

作者：桂阳海吴锦涛田宽郭会师张心华郑州轻工业大学材料与化学工程学院郑州450000 河南恒安电力股份有限公司郑州450001

近年来,H_(2)S作为哮喘和慢阻肺的新型生物标志物对人体健康监测具有重要意义,因此人们对低功耗、高选择性、低检出限和高稳定性H_(2)S传感器的研究显得十分迫切。通过两步原位生长的方式合成了Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3... 详细信息

近年来,H_(2)S作为哮喘和慢阻肺的新型生物标志物对人体健康监测具有重要意义,因此人们对低功耗、高选择性、低检出限和高稳定性H_(2)S传感器的研究显得十分迫切。通过两步原位生长的方式合成了Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3)纳米材料。以原位水热法合成的WO_(3)纳米片为基底,通过调控水浴反应时间,在WO_(3)纳米片上原位生长了不同的Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3)纳米材料。利用FE-SEM、FTIR、XRD和TG等方法对复合材料进行表征和气敏性能测试。结果表明:反应20 min所制得的Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3)复合材料具有最优异的气敏性能,在最佳工作温度(90℃)下对浓度为50×10^(−6)H_(2)S气体的响应值高达109,响应和恢复时间分别为130 s和182 s,对H_(2)S气体表现出优异的选择性。该复合材料在低浓度H_(2)S(3×10^(−6))氛围中,仍具有良好的响应恢复曲线。在一个月内进行的3次重复测试中,表现出较好的重复性和长期稳定性。Co(CO_(3))_(0.5)(OH)·0.11H_(2)O/WO_(3)气敏材料的原位制备及气敏性能研究为气敏传感器器件的制备提供了新思路,为气敏材料的多样性提供了新途径。在环境检测和智能医疗方面有着潜在的应用价值。

关键词：纳米材料 WO_(3) Co(CO_(3))_(0.5)(OH)·0.11H_(2)O H_(2)S 复合材料原位气敏

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Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

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Protein & Cell 2020年第3期11卷 161-186页

作者： Wei Li Wenchen Shen Bo Zhang kuan tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying Liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityMedical Research Institute at School of MedicineWuhan UniversityWuhan 430072China Department of Cell Biology Tianjin Medical UniversityQixiangtai Road 22Tianjin 300070China

The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive.Long non-coding RNAs(lncRNAs)have emerged as essential cell fate regulators.Here we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection neurons.Interestingly,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with hnRNPAB.Lineage tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection neurons.These observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation.

关键词： long non-coding RNA neuronal differentiation cerebral cortex KDM2B divergent lncRNA

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基于变换折衷阈值的多分辨图像双边滤波仿真

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计算机仿真 2024年第3期41卷 242-245页

作者：韦运玲王宽田四川工业科技学院电子信息与计算机工程学院四川德阳618000 桂林电子科技大学海洋工程学院广西北海536000

为了有效解决多分辨图像内存在噪声的问题,提出一种基于视觉灵敏度的多分辨图像双边滤波算法。通过粗糙集理论初步判断多分辨图像内的噪声,利用视觉灵敏度对判断结果展开修正。通过双边滤波器将噪声图像分解为高低频两个部分,高频部分使... 详细信息

为了有效解决多分辨图像内存在噪声的问题,提出一种基于视觉灵敏度的多分辨图像双边滤波算法。通过粗糙集理论初步判断多分辨图像内的噪声,利用视觉灵敏度对判断结果展开修正。通过双边滤波器将噪声图像分解为高低频两个部分,高频部分使用Curvelet变换折衷阈值,根据设定的阈值保留多分辨图像中更多的边缘纹理细节。将低频图像和处理后的高频图像重构,获取经过滤波处理后的多分辨图像。实验结果表明,所提算法可以精准检测出多分辨图像内存在的噪声,同时能够获取满意的多分辨图像滤波结果。

关键词：视觉灵敏度多分辨图像双边滤波

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Journal of Molecular Cell Biology 2017年第4期9卷 302-314页

作者： Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong kuan tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou Hubei Key Laboratory of Cell Homeostasis College of Life Sciences at Wuhan University Wuhan 430072 China Department of Neurosurgery The Tenth Affiliated Hospital Tongji University Shanghai 200072 China Department of Neurosurgery Fujian Medical University Union Hospital Fuzhou 350001 China Medical Research Institute Wuhan University Wuhan 430072 China Department of Neurosurgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston Houston TX 77225 USA

Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始，渗入，和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的... 详细信息

Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始，渗入，和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里，我们发现那配对的相关 homeobox 1 (PRRX1 ) ，以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发，在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步， PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强，而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后， PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此，我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。

关键词：多巴胺D2受体胶质瘤干细胞传播同源激活配对致瘤性

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基于半监督算法的高光谱影像特征提取仿真

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计算机仿真 2024年第4期41卷 229-232,309页

作者：万露武天刘纬王宽田电子科技大学成都学院四川成都611731 桂林电子科技大学海洋工程学院广西北海536000

高光谱影像包括待测物的空间、光谱和辐射三重信息,且图像信息具有维度高、空间相关性弱、特征非线性强的特点,导致其空间特征序列混乱,特征提取难度大。于是提出基于半监督算法的高光谱影像特征提取方法。应用半监督算法对高光谱图像... 详细信息

高光谱影像包括待测物的空间、光谱和辐射三重信息,且图像信息具有维度高、空间相关性弱、特征非线性强的特点,导致其空间特征序列混乱,特征提取难度大。于是提出基于半监督算法的高光谱影像特征提取方法。应用半监督算法对高光谱图像中的高维数据降维处理,并基于降维结果完成高光谱图像的去模糊。高光谱图像完成降维去模糊后,根据特征学习模型学习高光谱影像数据,获取图像深层特征。在像元空间内对深度特征以及空间信息完成空、谱的联合,实现高光谱影像特征的提取。实验结果表明,所提方法应用下影像特征点在特征空间内聚类效果好,查全率和查准率均能达到95%以上,说明上述方法的应用性能更优。

关键词：半监督算法高光谱图像图像去模糊数据降维特征提取方法

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Preparation and Properties of Fe-MOF Based Aerogels

Preparation and Properties of Fe-MOF Based Aerogels

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河南省化学会2018年学术年会

作者： Zhi-hong Zhang kuan tian Ya-shen Ma Bin Hu Henan Provincial Key Laboratory of Surface and Interface Science Zhengzhou University of Light Industry

a series of aerogels(MOAs)such as Fe-MOFs,Fe-MOFs/CN,Fe-Ti-MOFs-NH were prepared by freeze-drying.The morphology of the composites was characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD)and Fourier transform infrared spectroscopy(FTIR).The reaction temperature,reaction time,addition of raw materials,molar ratio of metal to ligand and other factors were found to affect the formation of airgel,and Fe-MOFs/CNappeared in the hole and lamellar structure.The catalytic degradation performance of Fe-MOAs was the best,and the adsorption of Congo-red(Congo)was complete in10 min,and the effect of Rhodamine B(RhB)on the degradation of organic dyes was evaluated by UV-Vis spectrophotometer.In 100 min adsorption degradation completely.

关键词： Organic dyes Catalytic degradation Fe-MOAs

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