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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho Son Ha Kyung Park Dae-Hwan Kim Jin-Kyu Kang Shi-Joon Sung Dae-Kue Hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo Kim Sang-Hoon Nam kee-jeong yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

Identifying the relationships between subsurface absorber defects and the characteristics of kesterite solar cells

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Carbon Energy 2023年第8期5卷 42-54页

作者： Dae-Ho Son Dong-Hwan Jeon Dae-Hwan Kim Jin-Kyu Kang Shi-Joon Sung Jaebaek Lee Taeseon Lee Enkhjargal Enkhbayar JunHo Kim kee-jeong yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea

Understanding the defect characteristics that occur near the space-charge regions(SCRs)of kesterite(CZTSSe)solar cells is important because the recombination loss at the CZTSSe/CdS interface is considered the main cause of their low *** surfaces with different elemental compositions were formed without polishing(C00)and with polishing for 20 s(C20)and 60 s(C60).For C60,a specific region near the SCR was excessively Cu-rich and Zn-poor compared to C00 and *** charged defects formed where the elemental variation was *** the main deep acceptor defect energy level(E_(a2))near the SCR increased,the efficiency,open-circuit voltage deficit,and current density degraded,and this phenomenon was especially rapid for large E_(a2) *** the E_(a2) near the SCR became deep,the carrier diffusion length decreased more for the CZTSSe solar cells with a low carrier mobility than for the CuInGaSe_(2)(CIGSe)solar *** large amplitude of the electrostatic potential fluctuation in the CZTSSe solar cells induced a high carrier recombination and a short carrier ***,the properties of the CZTSSe solar cells were more strongly degraded by defects with deep energy levels near the SCR than those of the CIGSe solar cells.

关键词： defect density defect energy level elemental variation kesterite space charge region

Flexible kesterite thin-film solar cells under stress

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npj Flexible Electronics 2022年第1期6卷 863-870页

作者： Ha Kyung Park Yunae Cho Juran Kim Sammi Kim Sungjun Kim Jeha Kim kee-jeong yang Dae-Hwan Kim Jin-Kyu Kang William Jo Department of Physics Ewha Womans UniversitySeoul 03760Republic of Korea Division of Energy Technology Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Solar&Energy Engineering Cheongju UniversityCheongju 28503Republic of Korea

Understanding the stress-induced phenomena is essential for improving the long-term application of flexible solar cells to non-flat ***,we investigated the electronic band structure and carrier transport mechanism of Cu2ZnSn(S,Se)4(CZTSSe)photovoltaic devices under mechanical *** efficient flexible CZTSSe devices were fabricated controlling the Na *** electronic structure of CZTSSe was deformed with stress as the band gap,valence band edge,and work function *** properties of the bent CZTSSe surface were probed by Kelvin probe force microscopy and the CZTSSe with Na showed less degraded carrier transport compared to the CZTSSe without *** local open-circuit voltage(VOC)on the bent CZTSSe surface decreased due to limited carrier *** reduction of local VOC occurred larger with convex bending than in concave bending,which is consistent with the degradation of device *** study paves the way for understanding the stress-induced optoelectronic changes in flexible photovoltaic devices.

关键词： optoelectronic stress bending

Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-a

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World Journal of Gastroenterology 2007年第13期13卷 1962-1965页

作者： Jae Sung Ko Hye Ran yang Ju Young Chang jeong kee Seo Department of Pediatrics Seoul National University College of Medicine Seoul 110-744 Korea

AIM： To determine whether Lactobacillus plantarum can modify the deleterious effects of tumor necrosis factor-α （TNF-α） on intestinal epithelial cells. METHODS： Caco-2 cells were incubated with TNF-α alone or in the presence of L. plantarum. Transepithelial electrical resistance was used to measure epithelial barrier function. Interleukin 8 （IL-8） secretion by intestinal epithelial cells was measured using an ELISA. Cellular lysate proteins were immunoblotted using the anti-extracellular regulated kinase （ERK）, anti-phospho- ERK and anti-IκB-α. RESULTS： A TNF-α-induced decrease in transepithelial electrical resistance was inhibited by L. plantarum. TNF- α-induced IL-8 secretion was reduced by L. plantarum. L. plantarum inhibited the activation of ERK and the degradation of IκB-α in TNF-a-treated Caco-2 cells. CONCLUSION： Induction of epithelial barrier dysfunction and IL-8 secretion by TNF-α is inhibited byL. plantarum. Probiotics may preserve epithelial barrier function and inhibit the inflammatory response by altering the signal transduction pathway.

关键词： Lactobacillus plantarum Tumor necrosisfactor-α Epithelial barrier Interleukin-8 ERK IκB-α

Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第13期18卷 1525-1530页

作者： Hye Ran yang Hae Ryoung Kim Myung Jin Kim Jae Sung Ko jeong kee Seo Department of Pediatrics Seoul National University College of MedicineSeoul 110-744South Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnam-siGyonggi-do 463-707South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam-siGyonggi-do 464-894 South Korea

AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each *** aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were ***:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant *** noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.

关键词： Fatty liver Hepatic fibrosis Noninvasive Obesity Child

Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways

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Chinese Journal of Natural Medicines 2017年第1期15卷 15-40页

作者： Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim yang Ho Park Dong kee jeong Laboratory of Animal Genetic Engineering and Stem Cell Biology Department of Animal Biotechnology Faculty of Biotechnology Jeju National University Jeju 63243 Republic of Korea Division of Veterinary Medicine Faculty of Veterinary Science & Animal Husbandry Sher-e-Kashmir University of Agricultural Sciences & Technology R.S. Pura Jammu 181102 India BRM Institute Seoul 06111 Republic of Korea

Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.

关键词： Anti-cancer Apoptosis Wogonin Signaling pathways Pharmacokinetics

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park kee Don Choi Beom Su Kim Moon-Won Yoo In Seob Lee jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn jeong Hoon Lee kee Wook Jung Do Hoon Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

Endoscopic submucosal dissection as alternative to surgery for complicated gastric heterotopic pancreas

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World Journal of Clinical Cases 2020年第20期8卷 4708-4718页

作者： Jin Hee Noh Do Hoon Kim So-Woon Kim Young Soo Park Hee Kyong Na Ji Yong Ahn kee Wook Jung jeong Hoon Lee kee Don Choi Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Gastric heterotopic pancreas(GHP)is generally asymptomatic and rarely features complications such as pancreatitis,pseudocysts,gastric outlet obstruction,bleeding,obstructive jaundice,or ***,the treatment of complicated GHP is challenging and often requires surgical *** To investigate the clinical outcomes of endoscopic submucosal dissection(ESD)as alternative to surgical resection for complicated *** This is a single-center,retrospective *** January 2013 and December 2017,a total of 5 patients underwent ESD for complicated GHP at Asan Medical *** who were diagnosed with complicated GHP were treated conservatively as with general practice for acute *** conservative management for resolving the acute phase of pancreatitis,ESD was performed as definitive treatment for complicated *** was performed using the conventional method under conscious *** clinical features of patients and tumors,procedure-related characteristics,and long-term outcomes were *** The age of the 5 patients ranged from 28-43 *** of the patients were *** lesions were located in the greater curvature of the *** endoscopic ultrasonography during the pain episode,all lesions were located across the muscularis mucosa,submucosa,and proper muscle *** median lesion size was 20[interquartile range(IQR),18-35]during the pain episode at the time of the diagnosis of complicated GHP,and 15 mm(IQR,9-33)at the time of ESD after conservative *** procedure time ranged from 15-120 *** were no procedure-related adverse events such as perforation or *** length of hospital stay after the procedure ranged from 2-4 *** patients were symptom free during the median follow-up period of 46.0 mo(IQR,39-60).CONCLUSION ESD appears to be a feasible and effective treatment option for complicated GHP based on the favorable clinical outcomes.

关键词： Endoscopic submucosal dissection Gastric Heterotopic pancreas Pancreatitis

Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes

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World Journal of Gastroenterology 2010年第14期16卷 1782-1787页

作者： jeong Hwan Kim Hyung Seok Park Soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim kee-Ho Song Dong-Lim Kim Sook Kyung Kim Jeeyoung Oh Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Medical Immunology Center Institute of Biomedical Science and Technology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Internal Medicine Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Neurology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea

AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.

关键词： Diabetes HbA1c Upper gastrointestinal symptoms

Global-Local Finite Element Analysis for Predicting Separation in Cord-Rubber Composites of Radial Truck Tires

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Open Journal of Modelling and Simulation 2019年第4期7卷 190-202页

作者： Kyoung Moon jeong kee Woon Kim Jang Hyeon Kim R&D Center Kumho Tire Co. Inc. Yongin-si Gyeonggi-do South Korea

A global-local finite element modeling technique is employed in this paper to predict the separation in steel cord-rubber composite materials of radial truck tires. The local model uses a finite element analysis in conjunction with a glob-al-local technique in ABAQUS. A 3-dimensional finite element local model calculates the maximum cyclic shear strain of an interface between steel cord and rubber materials at the carcass ply shoulder region. It is found that the maximum cyclic shear strain is reliable as a result of the analysis of carcass ply separation in radial truck tires. Using the analysis of the local model, a study of the cyclic shear strain is performed in the shoulder region and used to deter-mine the carcass ply separation. The effect of the change of carcass ply design on the separation in steel cord-rubber composite materials of radial truck tires is discussed.

关键词： Global-Local Finite Element Analysis Separation Composite Material Truck Tire