检索结果-南通市图书馆

Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease

World Journal of Hepatology 2015年第27期7卷 2749-2756页

作者： Aiko Fukui Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan kazunori Nakaoka Masashi Ohki Yuka Takagawa Tomoki Takamura Hiroyuki Kamei Kentaro Yoshioka Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University Department of Clinical Pharmacy Practice and Health Care Management Faculty of PharmacyMeijo University

AIM: To evaluate the efficacy of vitamin E treatment on liver stiffness in nonalcoholic fatty liver disease(NAFLD).METHODS: Thirty-eight NAFLD patients were administered vitamin E for > 1 year. The doses of vitamin E were 150, 300, or 600 mg; three times per day after each meal. Responses were assessed by liver enzyme levels [aspartate aminotransferase(AST), alanine aminotranferease(ALT), and γ-glutamyl transpeptidase(γ-GTP)], noninvasive scoring systems of hepatic fibrosis-4 [FIB-4 index and aspartate aminotransferaseto-platelet index(APRI)], and liver stiffness [velocity of shear wave(Vs)] measured by acoustic radiation force impulse elastography. Vs measurements were performed at baseline and 12 mo after baseline. The patients were genotyped for the patatin-like phospholipase domain containing 3(PNPLA3) polymorphisms and then divided into either the CC/CG or GG group to examine each group's responses to vitamin E treatment. RESULTS: We found marked differences in the platelet count, serum albumin levels, alkaline phosphatase levels, FIB-4 index, APRI, and Vs at baseline depending on the PNPLA3 polymorphism. AST, ALT, and γ-GTP levels(all P < 0.001); FIB-4 index(P = 0.035); APRI(P < 0.001); and Vs(P < 0.001) significantly decreased from baseline to 12 mo in the analysis of all patients. In the subset analyses of PNPLA3 genotypes, AST levels(P = 0.011), ALT levels(P < 0.001), γ-GTP levels(P = 0.005), APRI(P = 0.036), and Vs(P = 0.029) in genotype GG patients significantly improved, and AST and ALT levels(both P < 0.001), γ-GTP levels(P = 0.003), FIB-4 index(P = 0.017), and APRI(P < 0.001) in genotype CC/CG patients. CONCLUSION: One year of vitamin E treatment improved noninvasive fibrosis scores and liver stiffness in NAFLD patients. The responses were similar between different PNPLA3 genotypes.

关键词： Vitamin E Acoustic radiation force impulse Nonalco

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Autism Spectrum Traits in Adults Affect Mental Health Status via Early Maladaptive Schemas

引用

Psychology Research 2014年第5期4卷 336-344页

作者： Fumiyo Oshima Hirofumi Nishinaka kazunori Iwasa Emi Ito Eiji Shimizu Chiba University Graduate School of Medicine Chiba Japan Shujitsu University Okayama Japan Chiba University GraduateSchool of Medicine Chiba Japan

EMSs (early maladaptive schemas) may influence general health status and the development and maintenance of some psychiatric disorders. This study investigated whether early maladaptive schemas act as a mediator in the relationship between autistic traits and general health status in non-clinical adults. A cross-sectional questionnaire-based study was used. The AQ (Autism-Spectrum Quotient), YSQ (Young Schema Questionnaire), and GHQ (General Health Questionnaire) were administered to a non-clinical sample of 342 university students (N = 342,238 women and 112 men; mean age = 21.36 years, SD = 5.17). We found a significant relationship between autism spectrum traits and mental health, completely mediated by EMSs. Thus, higher autism spectrum trait scores predicted higher EMSs scores, which in turn predicted poorer mental health. Early maladaptive schemas appear to account for the mental health problems suffered by adults with autism spectrum traits. There are no additional data available.

关键词：心理健康状况自闭早期架构性状成年人心理健康问题 EMS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Nickel Catalyst Film Thickness and Cooling Condition for Synthesis of Monolayer Graphene by Thermal Chemical Vapor Deposition at 800 ℃

引用

材料科学与工程（中英文B版） 2015年第9期5卷 341-346页

作者： kazunori Ichikawa Hiroshi Akamatsu Yoshiyuki Suda Yoshiyuki Nonoguchi Yukiharu Uraoka Department of Electrical Engineering Kobe City College of Technology Kobecity Hyogo 651-2194 Japan Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi City AichL441-8580 Japan Grduate School of Materials Science Nara Institute of Science and Technology Ikoma City Nara 630-0192 Japan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of Two Si Layers Simultaneously Crystallized LTPS-TFT Memory by the Green Laser Irradiation

引用

材料科学与工程（中英文B版） 2013年第6期3卷 375-378页

作者： kazunori Ichikawa Hiroshi Akamatsu Koji Yamasaki Masahiro Horita Yukiharu Uraoka Department of Electrical Engineering Kobe City College of Technology Kobe City 651-2194 Japan Grduate School of Materials Science Nara Institute of Science and Technology Nara City 630-0192 Japan

Low temperature polyclstaline Si thin film transistor (LTPS-TFT) used for a liquid crystal display (LCD) is obtained by crystallizing a-Si (amorphous Si). Although excimer laser is commonly used for crystallization, green laser crystallization attracts attention in recent years due to two a-Si layers in staked substrate (a-Si/SiO2/a-Si/quartz) are crystallized only by one time of irradiation. In order that this stacked layer structure is the same as the structure of a flash memory, this technology is applied to improvement in a performance of a flash memory. As a result, even when laser irradiation from the back is performed, two Si layers simulataneous crystallization is possible. Compared with the irradiation from front, the field-effect mobilities of the irradiation from the back improved about 10 times. Furthermore, in order that the retention time is improving significantly, it indicated that the quality of the oxide film between two layers improves. This technology is a technology promising for the improvement in a performance of a flash memory.

关键词：激光照射一次结晶硅层闪速存储器内存评估 a-Si 准分子激光器

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Homology Modeling of Human Alpha-Glucosidase Catalytic Domains and SAR Study of Salacinol Derivatives

引用

Open Journal of Medicinal Chemistry（药物化学期刊） 2012年第3期

作者： Shinya Nakamura kazunori Takahira Genzoh Tanabe Osamu Muraoka Isao Nakanishi

来源：评论

学校读者我要写书评

暂无评论

磷酸化Stat3和磷酸化Akt及细胞周期蛋白D1在血管肉瘤中的表达

引用

中华皮肤科杂志 2007年第3期40卷 155-157页

作者：林能兴连昕占部和敬古江增隆涂亚庭华中科技大学同济医学院附属协和医院皮肤科武汉430022 日本九州大学附属病院皮肤科

目的探讨磷酸化细胞信号传导与转录活化因子3（Star3）和磷酸化Akt及细胞周期蛋白D1在血管肉瘤中的表达。方法采用免疫组化ABC的方法检测磷酸化Star3（p-Stat3）和磷酸化Akt（p-Akt）及细胞周期蛋白D1在21例血管肉瘤和15例毛细血管瘤... 详细信息

目的探讨磷酸化细胞信号传导与转录活化因子3（Star3）和磷酸化Akt及细胞周期蛋白D1在血管肉瘤中的表达。方法采用免疫组化ABC的方法检测磷酸化Star3（p-Stat3）和磷酸化Akt（p-Akt）及细胞周期蛋白D1在21例血管肉瘤和15例毛细血管瘤石蜡包埋切片中的表达。结果在21例血管肉瘤石蜡包埋切片中，有15例p-Stat3表达阳性，11例p-Akt表达阳性，16例细胞周期蛋白D1表达阳性；而在15例毛细血管瘤中仅有4例p-Stat3表达阳性，2例p-Akt表达阳性，4例细胞周期蛋白D1表达阳性，两组各阳性表达率分别经卡方检验发现，差异均有统计学意义（P〈0．05）。在血管肉瘤中，p-Star3阳性表达与细胞周期蛋白D1的阳性表达有相关性（r=0．62，P=0．003），而p-Akt阳性表达与细胞周期蛋白D1的阳性表达无相关性（r=-0．09，P=0．700）。结论 p-Stat3、p-Akt和细胞周期蛋白D1在血管肉瘤的形成机制中可能起一定的作用。

关键词：血管肉瘤血管瘤毛细管细胞周期蛋白D1 蛋白激酶类

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

毛母质瘤中β联蛋白的突变基因分析

引用

中华皮肤科杂志 2006年第9期39卷 497-499页

作者：夏建新占部和敬李玉林古江增隆吉林大学白求恩医学部第二医院皮肤科长春130041 日本九州大学医学部皮肤科吉林大学基础医学院病理生物学教研室

目的探讨β联蛋白的突变基因及其蛋白表达与毛母质瘤发生的关系。方法选取67例毛母质瘤的组织标本进行β联蛋白的免疫染色,提取基因组DNA,进行β联蛋白的PCR扩增及测序,用克隆、测序及限制性内切酶的方法证实突变的存在。结果毛母质瘤... 详细信息

目的探讨β联蛋白的突变基因及其蛋白表达与毛母质瘤发生的关系。方法选取67例毛母质瘤的组织标本进行β联蛋白的免疫染色,提取基因组DNA,进行β联蛋白的PCR扩增及测序,用克隆、测序及限制性内切酶的方法证实突变的存在。结果毛母质瘤中嗜碱粒细胞β联蛋白免疫染色阳性率为81%(26/32),β联蛋白外显子3基因突变率为61%(14/23)。其突变均位于β联蛋白外显子3的磷酸化位点或邻近位点。结论β联蛋白的基因突变及其核阳性与毛母质瘤的发生有关。

关键词：毛基质瘤突变 β联蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

引用

World Journal of Gastroenterology 2015年第35期21卷 10215-10223页

作者： Keisuke Osakabe Naohiro Ichino Toru Nishikawa Hiroko Sugiyama Miho Kato Ai Shibata Wakana Asada Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan kazunori Nakaoka Yuka Takagawa Masashi Ohki Takamitsu Kurashita Tomoki Takamura Kentaro Yoshioka Faculty of Medical Technology School of Health SciencesFujita Health University Center of Ultrasound Diagnosis Fujita Health University Hospital Department of Liver Biliary Tract and Pancreas DiseasesFujita Health University

AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis ***: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after ***: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

关键词： Hepatitis C virus Fibrosis Interferon and ribaviri

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

净水用的带喷咀的射流反应器

引用

水处理信息报导 2002年第3期 39-39页

作者： Sato,kazunori

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of risky varices in alcoholic cirrhosis with a well-maintained nutritional status

引用

World Journal of Hepatology 2015年第21期7卷 2358-2362页

作者： Hirayuki Enomoto Yoshiyuki Sakai Yoshinori Iwata Ryo Takata Nobuhiro Aizawa Naoto Ikeda Kunihiro Hasegawa Chikage Nakano Takashi Nishimura kazunori Yoh Akio Ishii Tomoyuki Takashima Hiroki Nishikawa Hiroko Iijima Shuhei Nishiguchi Division of Hepatobiliary and Pancreatic Disease Department of Internal Medicine Hyogo College of Medicine

AIM: To compare the nutritional status between alcoholic compensated cirrhotic patients and hepatitis C virus(HCV)-related cirrhotic patients with portal ***: A total of 21 patients with compensated cirrhosis(14 with HCV-related cirrhosis and seven with alcoholic cirrhosis) who had risky esophageal varices were investigated. In addition to physical variables, including the body mass index, triceps skinfold thickness, and arm-muscle circumference, the nutritional status was also assessed using the levels of pre-albumin(pre-ALB), retinol-binding protein(RBP) and non-protein respiratory quotient(NPRQ) measured with an indirect ***: A general assessment for the nutritional status with physical examinations did not show a significant difference between HCV-related cirrhosis and alcoholic cirrhosis. However, the levels of pre-ALB and RBP in alcoholic compensated cirrhotic patients were significantly higher than those in HCV-related compensated cirrhotic patients. In addition, the frequency of having a normal nutritional status(NPRQ ≥ 0.85 and ALB value > 3.5 g/d L) in alcoholic compensated cirrhotic patients was significantly higher than that in HCV-related compensated cirrhotic ***: According to our small scale study, alcoholic compensated cirrhotic patients can develop severe portal hypertension even with a relatively well-maintained liver function and nutritional status compared with HCV-related cirrhosis.

关键词： Alcoholic liver cirrhosis Hepatitis C virus Rapid-

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：