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匈牙利土地管理制度及其对中国的借鉴

东南学术 2009年第2期 72-82页

作者：林卿林翊王荧 Gombas katalin[匈] 福建师范大学经济学院教授、博士生导师福建师范大学经济学院博士研究生匈牙利西匈牙利大学地球信息学院

丰富的土地资源是匈牙利国家最为宝贵的财富,中匈有过相似的经济体制背景与土地管理制度改革历程,研究匈牙利土地管理制度具有重要的借鉴意义。文章分析了匈牙利土地管理制度演变过程,土地管理制度创新、效率、问题与发展趋势,土地市场... 详细信息

丰富的土地资源是匈牙利国家最为宝贵的财富,中匈有过相似的经济体制背景与土地管理制度改革历程,研究匈牙利土地管理制度具有重要的借鉴意义。文章分析了匈牙利土地管理制度演变过程,土地管理制度创新、效率、问题与发展趋势,土地市场发展,土地管理的主要法律,土地管理体系,以及可借鉴的经验。

关键词：句牙利土地管理制度

Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease

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World Journal of Gastroenterology 2006年第34期12卷 5550-5553页

作者： Judit Bene Lili Magyari Gábor Talián katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Pécs Hungary Department of Medical Genetics and Child Development University of Pécs Pécs Hungary Department of Medical Genetics and Child Development University of Pécs Pécs Hungary 1~(st) Department of Medicine School of Medicine University of Pécs Pécs Hungary Department of Pediatrics and Child Health Center University of Szeged Szeged Hungary

AIM： To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn＇s disease （CD）. METHODS： A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn＇s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants （Arg702Trp, Gly908Arg and 2007finsC changes） with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specific regions of these genes. RESULTS： At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profile was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls （9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls）. No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION： The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD.

关键词： OCTN1 OCTN2 NOD2/CARD15 Crohn's disease

Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

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World Journal of Gastroenterology 2006年第2期12卷 251-258页

作者： Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs st Department of Medicine University of SzegedHungary Department of Cellular and Structural Biology University of TexasHealth Science CentreSan AntonioTexasUnited States Institute of Chemistry University of SzegedHungary Biological Research Centre Hungarian Academy of SciencesSzegedHungary Biological Isotope Laboratory University of SzegedHungary Institute of Experimental Surgery University of SzegedHungary

AIM： To determine the effect of melatonin pre- and post-treatment on the severity of L-arginine （L-Arg） -induced experimental pancreatitis in rats. METHODS： Male Wistar rats （25） were divided into five groups. Those in group A received two injections of 3.2 g/kg body weight L-Arg i.p. at an interval of 1 h. In group MA, the rats were treated with 50 mg/kg body weight melatonin i.p. 30 min prior to L-Arg administration. In group AM, the rats received the same dose of melatonin 1 h after L-Arg was given. In group M, a single dose of melatonin was administered as described previously. In group C the control animals received physiological saline injections i.p. All rats were exsanguinated 24 h after the second L-Arg injection. RESULTS： L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio （pw/bw）, the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values. Elevation of the serum amylase level was significantly reduced in rats given melatonin following L-Arg compared to rats injected with L-Arg only. The activities of the pancreatic antioxidant enzymes （Cu/Zn-superoxide dismutase （CulZn-SOD） and catalase （CAT）） were significantly increased 24 h after pancreatitis induction. Melatonin given in advance of L-Arg significantly reduced the pancreatic CAT activity relative to that in the rats treated with L-Arg alone. In the liver, L-Arg significantly increased the lipid peroxidation level, and the glutathione peroxidase and Cu/Zn-SOD activities, whereas the Mn-SOD activity was reduced as compared to the control rats. Melatonin pre-treatment prevented these changes. CONCLUSION： Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis.

关键词： Acute pancreatitis Melatonin Scavengers

New serological markers in pediatric patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 4873-4882页

作者： Márta Kovács katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres Department of Pediatrics Petz Aladár County and Teaching Hospital9023 Gy?rHungary 1~(st) Department of Pediatrics Semmelweis University1083 BudapestHungary 2~(nd) Department of Medicine University of Debrecen4032 DebrecenHungary 1~(st) Department of Medicine Semmelweis University1083 BudapestHungary Department of Gastroenterology Petz Aladár County and Teaching Hospital9023 Gy?rHungary

The spectrum of serological markers associated with inflammatory bowel disease (IBD) is rapidly growing. Due to frequently delayed or missed diagnoses, the application of non-invasive diagnostic tests for IBD, as well as differentiation between ulcerative colitis (UC) and Crohn’s disease (CD), would be useful in the pediatric population. In addition, the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody (pANCA) improved the sensitivity of serological markers in pediatric patients with CD and UC. Some studies suggested that age-associated differences in the patterns of antibodies may be present, particularly in the youngest children. In CD, most patients develop stricturing or perforating complications, and a significant number of patients undergo surgery during the disease course. Based on recent knowledge, serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery. Pediatric UC is characterized by extensive colitis and a high rate of colectomy. In patients with UC, high levels of anti-CBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis. Thus, serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression. In conclusion, identification of patients at an increased risk of rapid disease progression is of great interest, as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD, and reduce complications and hospitalizations.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Pediatric, Serologic markers, Antimicrobial antibodies, Anti-glycan antibodies, Pancreatic antibodies, Inflammatory bowel disease

No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples

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World Journal of Gastroenterology 2007年第15期13卷 2205-2208页

作者： Lili Magyari Bernadett Faragó Judit Bene katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh Department of Medical Genetics and Child Development University of Pécs PécsHungary MTA PTE Clinical Genetics Research Group of the Hungarian Academy of Sciences at the University of Pécs Pécs Hungary Markusovszky Hospital Department of Medicine and Gastroenterology SzombathelyHungary Réthy Pál Hospital 3rd Department of Medicine and Gastroenterology BékéscsabaHungary Department of Medicine School of Medicine University of PécsPécsHungary Department of Gastroenterology Zala County Hospital ZalaegerszegHungary

AIM： The goal of the current work was to analyse the prevalence of the ＋49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene （CTLA4） in Hungarian patients with Crohn＇s disease （CD） and ulcerative colitis （UC）. METHODS： A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism （SNP）. The genotypes were determined by using PCR/RFLP test. RESULTS： The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION： The results of the current study show that carriage of the ＋49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.

关键词： Cytotoxic T-lymphocyte antigen 4 Crohn's disease Ulcerative colitis Inflammatory bowel disease

Quality control,validation and user feedback of the European Flood Alert System(EFAS)

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International Journal of Digital Earth 2011年第S1期4卷 77-90页

作者： Ad De Roo Jutta Thielen Peter Salamon Konrad Bogner Sebastien Nobert Hannah Cloke David Demeritt Jalal Younis Milan Kalas katalin Bodis Davide Muraro Florian Pappenberger European Commission Joint Research Centre(JRC)IspraItaly European Centre for Medium Range Weather Forecast(ECMWF) ReadingUK Department of Geography King’s College LondonLondonUK Czech Hydrometeorological Institute PragueCzech Republic

The quality control,validation and verification of the European Flood Alert System(EFAS)are *** is designed as a flood early warning system at pan-European scale,to complement national systems and provide flood warnings more than 2 days before a *** average 2030 alerts per year are sent out to the EFAS partner network which consists of 24 National hydrological authorities responsible for transnational river *** control of the system includes the evaluation of the hits,misses and false alarms,showing that EFAS has more than 50%of the time ***,the skills of both the meteorological as well as the hydrological forecasts are evaluated,and are included here for a 10-year ***,end-user needs and feedback are systematically *** improvements,such as real-time river discharge updating,are currently implemented.

关键词： flood warning forecasting EFAS probabilistic skill

Severity of gastroesophageal reflux disease influences daytime somnolence: A clinical study of 134 patients underwent upper panendoscopy

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World Journal of Gastroenterology 2004年第12期10卷 1798-1801页

作者： Pái Demeter katalin Várdi Visy Nóra Gyulai Róbert Sike Tamás G Tóth János Novák Pál Magyar Outpatient Clinic of Gastroenterology St.John's HospitalBudapestHungary Department of Pulmonology Semmelweis Medical UniversityBudapestHungary Dept.of

AIM: To asses the relationship between severity of gastroesophageal refluxe disease and Epworth sleepiness scale as an indicator of daytime somnolence. METHODS: One hundred and thirty-four patients underwent an upper panendoscopy as indicated by the typical reflux symptoms and were also investigated with regard to somnolence. Sleepiness was evaluated by Epworth Sleepiness Scale, which was compared to the severity of endoscopic findings (Savary-Miller/modified by Siewert). Patients with psychiatric disorders or being on sedato-hypnotics as well as shift workers were excluded from the study. The relationship between the severity of the reflux disease and daytime somnolence was analyzed with the help of multivariate regression analysis. RESULTS: A positive tendency was found between the severity of the reflux disease and the corresponding Epworth Sleepiness Scale. In the case of the more severe type-Savary-Miller Ⅲ- at least a mild hypersomnia was found. For this group daytime somnolence was significantly higher than in the case of the non-erosive type of Gastroesophageal Reflux Disease representing the mildest stage of reflux disease. CONCLUSION: The severity of Gastroesophageal Reflux Disease influences daytime somnolence.

关键词： Severity of Illness Index Adult Aged Disorders of Excessive Somnolence Endoscopy, Digestive System Female Gastroesophageal Reflux Humans Linear Models Male Middle Aged Predictive Value of Tests

Response of <i>Arabidopsis</i>Clones to Toxic Compounds Released by Various <i>Rhizoctonia</i>Species

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American Journal of Plant Sciences 2014年第3期5卷 364-371页

作者： Gyula Oros András Bittsánszky katalin Pilinszky Plant Protection Institute of the Centre for Agricultural Research of the Hungarian Academy of Sciences Budapest Hungary

Response of 3 Arabidopsis clones to 41 strains of eight Rhizoctonia species was studied in model experiments. The seed germination was decelerated in most of the cases, although the inhibitory effect varied within large limits. The pre-emergence damping off and root neck rot leading to damping off were the most frequent symptoms of disease syndrome caused by toxic metabolites. The clone transformed with cDNA clone overexpressing gstf4 gene exhibited significantly improved tolerance as compared to parental one, meanwhile the sensitivity of Dmannose pyrophosphorylase/mannose-1-pyrophosphatase deficient clone dramatically increased. Strains of R. solani of AG-2, AG-4 and AG-7 and Athelia rolfsii produced the most toxic metabolites, however, no strict relationships were revealed between taxonomic position of Rhizoctonia strains and toxicity of their metabolites.

关键词： Arabidopsis Rhizoctonia Toxin Athelia Ceratobasidium Ceratorhiza Thanatephorus Waitea

Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies

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World Journal of Gastroenterology 2014年第41期20卷 15343-15350页

作者： Gabor Lendvai katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss MTA-SE Tumor Progression Research Group Semmelweis University 1st Department of Medicine University of Szeged 2nd Department of Pathology Semmelweis University 1st Department of Pathology and Experimental Cancer Research Semmelweis University

AIM: To assess the expression of selected microRNAs (miRNA) in hepatitis C, steatotic hepatitis C, noninfected steatotic and normal liver tissues.

关键词： Chronic hepatitis C Steatosis MicroRNA Expression miR-33a miR-224