No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples

作     者：Lili Magyari Bernadett Faragó Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh 

作者机构：Department of Medical Genetics and Child Development University of PécsPécsHungary MTA PTE Clinical Genetics Research Group of the Hungarian Academy of Sciences at the University of Pécs PécsHungary Markusovszky Hospital Department of Medicine and GastroenterologySzombathelyHungary Réthy Pál Hospital 3rd Department of Medicine and GastroenterologyBékéscsabaHungary Department of Medicine School of MedicineUniversity of PécsPécsHungary Department of Gastroenterology Zala County HospitalZalaegerszegHungary 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第15期

页      面：2205-2208页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the grants of Hungarian Science Foundation (OTKA T 0495X9) Hungarian Ministry of Health (ETT 497/2006) by the National Office for Research and Technology, "Pazmany Peter" program. (RET- II 08/2005) 

主　　题：Cytotoxic T-lymphocyte antigen 4 Crohn's disease Ulcerative colitis Inflammatory bowel disease 

摘      要：AIM： The goal of the current work was to analyse the prevalence of the ＋49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene （CTLA4） in Hungarian patients with Crohn＇s disease （CD） and ulcerative colitis （UC）. METHODS： A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism （SNP）. The genotypes were determined by using PCR/RFLP test. RESULTS： The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION： The results of the current study show that carriage of the ＋49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.