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Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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Journal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-Martinez Pedro JoseFlores-Blanco juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro francisco Arregui-Montoya Francisca Maria Munoz-Franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo Domingo Andres Pascual-Figal Sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of *** aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December *** was defined as moderate or severe according to European echocardiography guidelines ***,ATRIA and ORBIT scores were used to evaluate the bleeding *** was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of *** 168(5.8%)patients had *** with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest *** and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of *** In this population,AS was associated with an increased risk for MB at midterm *** three scoring systems showed a moderate discriminatory ability for ***,the addition of AS was associated with a significant improvement in their predictive *** suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Major bleeding Valvular disease

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Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens

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Plant Communications 2021年第3期2卷 93-104页

作者： Lourdes Castelblanque Javier García-Andrade Clara Martínez-Arias juan J.Rodríguez francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera Instituto de Biología Moleculary Celular de Plantas Universitat Politécnica de Valéncia-C.S.I.CCiudad Politécnica de la InnovaciònEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain Universitat Jaume I Departament de Ciéncies Agráries i del Medi NaturalCampus del Riu Sec12003 Castellòde la PlanaSpain

More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are *** is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire *** constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be *** identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest *** provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus *** marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis ***,a latex-derived factor required for conidia germination on the leaf surface was *** factor promoted disease susceptibility enhancement even in the non-latex-bearing plant *** speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies.

关键词： latex Euphorbia lathyris disease resistance disease susceptibility plant defense

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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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不明原因发热患者的临床特征和实验室检查结果对18F-FDG PET/CT显像诊断效能的影响

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中华核医学与分子影像杂志 2018年第8期38卷 582-583页

作者：唐军 Ana María García-Vicente María Jesús Tello-Galán Mariano Amo-Salas juan Ros-Izquierdo German Andrés jim.nez-Londofio Beatriz La Rosa Salas Guadalupe Prado-Serrano Pradas francisco José Pena-Pardo ngel Soriano-Castrejón 上海交通大学医学院附属苏州九龙医院核医学科 Nuclear Medicine Department University General HospitalCiudad RealSpain

目的评价患者临床特征及实验室检查结果对18F-脱氧葡萄糖(FDG) PET/CT显像诊断不明原因发热(FUO)的影响。方法回顾性纵向分析FUO患者的PET/CT显像结果。参考标准为血清学检查、各种细菌培养或活组织检查结果,必要时参考其他实验室检查... 详细信息

目的评价患者临床特征及实验室检查结果对18F-脱氧葡萄糖(FDG) PET/CT显像诊断不明原因发热(FUO)的影响。方法回顾性纵向分析FUO患者的PET/CT显像结果。参考标准为血清学检查、各种细菌培养或活组织检查结果,必要时参考其他实验室检查或临床随访结果。收集患者PET/CT显像近几天内的临床特征、炎性标志物、蛋白质分析、血清学检查和细菌培养结果。根据不同病因最终诊断分为3组:第1组为感染或肿瘤,第2组为脉管炎、自身免疫性疾病或非感染性炎性疾病,第3组为未明确诊断的自限性发热或持续性发热。PET/CT显像结果分为阳性或阴性、有助于或无助于诊断发热来源。分析患者临床特征和实验室检查结果对PET/CT结果的影响。结果 67例患者最终诊断分组为:第1组25例,第2组20例,第3组22例。89.6%的患者炎性标志物阳性,28.4%的蛋白质检测阳性,20.9%的细菌培养结果阳性。67例患者中,PET/CT显像阳性52例,25例有助于诊断发热来源,其中对第1组和第2组帮助尤其大。PET/CT显像的灵敏度、特异性和准确性分别为84%、31%和61%。PET/CT显像结果与最终诊断(P=0.035)和细菌培养结果(P=0.037)相关,而与其他临床特征或实验室检查结果无明显相关性。结论18F-FDG PET/CT显像诊断FUO的灵敏度高,但特异性低,可能的原因是FUO的病原范围很广,也有一些是自限性发热。最有可能从PET/CT显像获益的患者是那些多种炎性标志物阳性的患者,这些患者有活动性病变的可能性更高。

关键词：不明原因发热(FUO) 18F-FDG PET/CT 炎性标志物诊断

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Variables of Suicidal Behavior in Tenerife Years 2011-2012: Proposals for the Prevention

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Forensic Medicine and Anatomy Research 2014年第2期2卷 37-41页

作者： Sergio Manuel Martínez Aguilar Milagros De la Rosa Hormiga juan Manuel Herrera Hernández francisco Rodríguez Pulido Candelaria de la Merced Díaz-González Forensic Department Tenerife Spain Servicio Canario de la Salud Tenerife Spain Universidad de La Laguna Tenerife Spain

Suicide is treated by society as a taboo subject despite it being the leading cause of unnatural death in Spain. The Tenerife Province is ranked 16th among the 52 Spanish provinces for its suicide rate. From 2007 till 2010, the rate increased from 2007 to 2008, then dropped in 2010. Slight rise occurred in suicide rates in 2010. This rate increased from 2007 to 2008, with a decrease of rate in 2010. Slight rise occurred in suicide rates in 2010. In 2013 the province saw 75 suicides per year. 90% - 98% of suicides are closely related to mental disease with the remaining 10% associated with different poor causes of the subject, according to bibliography. In this retrospective study, it has been found that the highest risk rests with men over 40 years of age in the central and southern part of the island. Among the forms of suicide reported, the most common is hanging followed by jumping from a height. It’s important to understand the reasons behind suicidal behavior from a psychosocial perspective, taking into account “unsafe” indicators and individual profiles. The lethal nature of a suicide attempt also depends on the form of suicide adopted and the possibility of a rescue. Specific protocols to prevent suicide should be promoted and discussed between health and social services.

关键词： Consummated Suicide Autopsy Violent Death Autopsy Psychosocial

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Draft of Spanish Standard for the Use of Recycled Aggregate in the Production of Structural Concrete

Draft of Spanish Standard for the Use of Recycled Aggregate ...

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The 6th International Symposium on Cement & Concrete and Canmet/Aci International Symposium on Concrete Technology for Sustainable Development

作者： Pilar Alaejos Marta Sánchez de juan Marilda Barra Manuel Burón Enrique Dapena Miren Etxebarría Gilbert francisco Belén González Fonteboa Fernando Martínez Abella Isabel Martínez Lage José Luis Parray Alfaro juan Antonio Polanco Mariano Sanabria Enric Vázquez Task Force of Standing Committee of Concrete

In November 2002, the Spanish Standing committee of Concrete created a task force commissioned to draft a document to complement current regulations on structural concrete and to set out specific reco

关键词： Recycled concrete aggregate, Standardization, structural concrete.

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Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

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World Journal of Vaccines 2023年第2期13卷 13-32页

作者： Victoria Delicado-Useros Esther Navarro-Rodenas Indalecio-M Sánchez-Onrubia Carmen Ortega-Martínez Antonia Alfaro-Espín juan-D Pérez-Serra francisco García-Alcaraz Julia Lozano-Serra Lorena Robles-Fonseca Teresa Pérez-Domenech Nursing Faculty Castilla-La Mancha University Nursing & Society Research Group Albacete Spain Emergency Department General Hospital Almansa Spain Emergency Department General Hospital Albacete Spain Nursing Faculty Nursing & Society Research Group Universidad de Castilla-La Mancha Albacete Spain Emergency Department Son Espasses Universitary Hospital Palma de Mallorca Spain Departament of Clinical Microbiology in Albacete General Hospital Albacete Spain

Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.

关键词： Acquired Immunity SARS-CoV-2 Vaccine IgG level Healthcare Workers COVID-19 Incidence Rate

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Design and Development of Impeller Synergic Systems of Electromagnetic Type to Levitation/Suspension Flight of Symmetrical Bodies

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Journal of Electromagnetic Analysis and Applications（电磁分析与应用期刊） 2012年第1期

作者： francisco Bulnes juan Carlos Maya Isaías Martínez

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New frontiers in focal therapy for prostate cancer:Prostate-specific membrane antigen positron emission tomography/magnetic resonance imaging

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World Journal of Clinical Oncology 2021年第2期12卷 61-68页

作者： Celeste Manfredi Esau Fernandez-Pascual Estefanía Linares-Espinós Felipe Couñago juan Ignacio Martínez-Salamanca Department of Woman Child and General and Specialized SurgeryUrology UnitUniversity of Campania“Luigi Vanvitelli”Naples 81110Italy Department of Urology Hospital Universitario La PazMadrid 28046Spain LYX Institute of Urology Facultad de MedicinaUniversidad Francisco de VitoriaPozuelo de Alarcón 28223MadridSpain Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Urology Hospital Universitario Puerta Hierro-MajadahondaMajadahonda 28222MadridSpain

Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of *** papers reported the potential advantages of PSMA PET/MRI in different clinical *** evidence on PSMA PET/MRI is available in the setting of *** PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary *** PET/MRI also shows high performance for restaging and detecting tumor *** higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed *** PET/MRI could represent a turning point in the management of patients with PCa in the context of *** studies are needed to confirm its applications in this specific clinical setting.

关键词： Prostate-specific membrane antigen Positron emission tomography/magnetic resonance imaging Prostate cancer Focal therapy High-intensity focused ultrasound Cryotherapy

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Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial

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World Journal of Gastroenterology 2015年第23期21卷 7305-7312页

作者： francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García juan E Domínguez-Suárez Pedro A López-Saura 无 Clinical Research Direction Center for Genetic Engineering and Biotechnology juan B.Zayas Hospital Ernesto Guevara Hospital Celia Sánchez Hospital Manzanillo Gustavo Aldereguía Hospital THERESA-4(Treatment of HEmorrhoids with REcombinant Streptokinase Application)Group of Investigators

AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal ***: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also ***: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and he

关键词： Streptokinase Suppository Hydrocortisoneacetate Thrombolysis Hemorrhoids Randomizedclinical trial

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