Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

作     者：Victoria Delicado-Useros Esther Navarro-Rodenas Indalecio-M Sánchez-Onrubia Carmen Ortega-Martínez Antonia Alfaro-Espín Juan-D Pérez-Serra Francisco García-Alcaraz Julia Lozano-Serra Lorena Robles-Fonseca Teresa Pérez-Domenech Victoria Delicado-Useros;Esther Navarro-Rodenas;Indalecio-M Sánchez-Onrubia;Carmen Ortega-Martínez;Antonia Alfaro-Espín;Juan-D Pérez-Serra;Francisco García-Alcaraz;Julia Lozano-Serra;Lorena Robles-Fonseca;Teresa Pérez-Domenech

作者机构：Nursing Faculty Castilla-La Mancha University Nursing & Society Research Group Albacete Spain Emergency Department General Hospital Almansa Spain Emergency Department General Hospital Albacete Spain Nursing Faculty Nursing & Society Research Group Universidad de Castilla-La Mancha Albacete Spain Emergency Department Son Espasses Universitary Hospital Palma de Mallorca Spain Departament of Clinical Microbiology in Albacete General Hospital Albacete Spain 

出 版 物：《World Journal of Vaccines》 (疫苗（英文）)

年 卷 期：2023年第13卷第2期

页      面：13-32页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Acquired Immunity SARS-CoV-2 Vaccine IgG level Healthcare Workers COVID-19 Incidence Rate 

摘      要：Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.