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Hello,can you hear me?Orthopaedic clinic telephone consultations in the COVID-19 era-a patient and clinician perspective

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World Journal of Orthopedics 2021年第1期12卷 24-34页

作者： Anuhya Vusirikala David Ensor Ajay K Asokan Alvin jx lee Ravi Ray Dimitrios Tsekes John Edwin Department of Trauma and Orthopaedics Basildon University HospitalBasildon SS165NLEssexUnited Kingdom Medical Oncology UCL Cancer InstituteLondon WC1E 6BTUnited Kingdom

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has resulted in seismic changes in healthcare *** a result of this,hospital footfall required to be reduced due to increased risk of transmission of *** ensure patients can safely access healthcare,we introduced orthopaedic clinic telephone consultations in our busy district general *** To investigate patients’and clinicians’perspective of telephone consultations during COVID-19,and whether this method of consultation could be a viable option in the post-pandemic *** This is a single centre,prospective study conducted in a busy National Health Service district general *** May 2020,100 non-consecutive adult patients were contacted by independent investigators within 48 h of their orthopaedic clinic telephone consultation to complete a telephone satisfaction *** questions assessed satisfaction regarding various aspects of the consultation including overall satisfaction and willingness to use this approach long *** and perspective of 25 clinicians conducting these telephone consultations was also assessed via an online survey *** 93%of patients were overall satisfied with telephone consultations and 79%were willing to continue this method of consultation *** found telephone consultations to reduce personal cost and inconvenience associated with attending a hospital appointment.72%of clinicians reported overall satisfaction with this service and 80%agreed that telephone consultations should be used in the *** majority found it less laborious in time and administration in comparison to face to face *** and clinicians expressed their desire for video consultations as a method of further improving their experience with remote *** Our study has shown that telephone consultations are a safe and rapid method of adaptation to the COVID-19 pandemic,achieving the aim of reduci

关键词： COVID-19 Telephone consultation Orthopaedic clinic Patient satisfaction Patient perspective Clinician perspective

Efficacy of the herbal pair, Radix Achyranthis Bidentatae and Eucommiae Cortex, in preventing glucocorticoid-induced osteoporosis in the zebrafish model

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Journal of Integrative Medicine 2022年第1期20卷 83-90页

作者： Joon-ho lee Yuan-ji Wei Zhong-yan Zhou Yu-ming Hou Cheng-long Wang Li-bo Wang Hong-jin Wu Yu Zhang Wei-wei Dai Central Laboratory of Science and Technology Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cardiovascular Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: In traditional Chinese medicine, the herbal pair, Radix Achyranthis Bidentatae(RAB) and Eucommiae Cortex(EC), is widely used to treat osteoporosis. Herein, we determined whether this herbal pair can be used to ameliorate glucocorticoid(GC)-induced osteoporosis(GIOP) and find its optimal dosage in ***: The characteristics of the aqueous extract of RAB and EC were separately characterized using high-performance liquid chromatography. Osteoporosis was induced in 5-day post-fertilization zebrafish larvae by exposing them to 10 lmol/L dexamethasone(Dex) for 96 h. Seven combinations of different ratios of RAB and EC were co-administered. Treatment efficacy was determined by calculating zebrafish vertebral area and sum brightness, via alizarin red staining, and by detecting alkaline phosphatase(ALP)activity. Multiple regression analysis was conducted to test the optimal dosage ***: According to the Chinese Pharmacopoeia(2015), b-ecdysone(b-Ecd) is a major bioactive marker in RAB extract, while pinoresinol diglucoside(PDG) is the major marker in EC extract. Both of b-Ecd and PDG content values aligned with the Chinese Pharmacopoeia standards. Treatment with 10 lmol/L Dex reduced zebrafish vertebral area, sum brightness, and ALP activity, but RAB and EC attenuated these effects. Combining 50 mg/m L RAB and 50 mg/m L EC was optimal for preventing GIOP in *** transcription-quantitative polymerase chain reaction was used to evaluate the m RNA expression of osteogenesis-related genes. A treatment of 10 lmol/L Dex decreased runt-related transcription factor 2(Runx2), osteogenic protein-1(OP-1), bone c-carboxyglutamic acid-containing protein(BGLAP), and bcatenin levels. This effect was counteracted by RAB and EC co-treatment(P < 0.05). Additionally, the effect of using the two herbal extracts together was better than single-herb treatments separately. These results demonstrated that RAB and EC preserve osteoblast function in the pre

关键词： Glucocorticoid Osteoporosis Radix Achyranthis Bidentatae Eucommiae Cortex Zebrafish

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jx建筑公司现金流量管理研究

JX建筑公司现金流量管理研究

作者：李昕龙（lee Xinlong）西安理工大学

学位级别：硕士

现代公司财务管理都信奉“现金为王”的经营理念。公司维持日常的经营活动和最终盈利都是以公司现金流充足以及正常循环为基本前提的。建筑公司如要在当前激烈的市场竞争中分一杯羹,工程成本的管理显得尤为重要。但是,目前情况下,绝大... 详细信息

现代公司财务管理都信奉“现金为王”的经营理念。公司维持日常的经营活动和最终盈利都是以公司现金流充足以及正常循环为基本前提的。建筑公司如要在当前激烈的市场竞争中分一杯羹,工程成本的管理显得尤为重要。但是,目前情况下,绝大多数建筑公司对成本的管理仅限于原材料成本、人工成本以及机械成本,而忽视了最为重要的现金流管理。比如:原材料积压、工程结算不及时、工程款迟迟收不回来、工程项目招投标未考虑资金价值,以上种种问题最终使得公司在资金链上出现严重问题,公司的经营风险以及财务危机也随之而来,这些都会为公司造成不可估量的后果。本文以jx建筑公司为研究对象,对公司财务报表相关数据进行整理分析,并搜集了公司层、项目部层面现金流方面的数据资料,以及公司筹资、经营活动中相关数据,进行详细的分析归纳,最终建立符合jx公司自身的现金流管理体系。本文首先从财务状况、现金流量、经营成果三个方面分析了jx公司现金流管理的现状,得出四方面的问题:第一,现金流管理体系不完整;第二,工程结算滞后;第三,融资结构不合理;第四,应收账款严重挂账;其次,分析jx公司存在问题的原因主要有:第一,现金流管理意识薄弱;第二,现金流管理模式过于分散;第三,资金预算管理制度不合理;第四,战略定位不明确;再次,通过以上所有的分析,建立jx公司现金流管理体系,第一,介绍了现金流管理体系的整体构架,现金流循环情况以及之间的协调和控制;第二,设计现金流管理体系的具体实施方案和实施原则,并从从宏观角度阐释了现金流管理办法;第三,介绍了现金流管理体系实施效果的评价方法,以及最新年度的应用结果。最后,从三方面提出了相应的保障措施:第一,提高现金流管理人才素质;第二,提高现金流预算的编制水平;第三,加强现金流内部控制及考核力度。文中关于jx公司现金流管理体系的设计思路和具体实施内容对建筑行业内中小型公司具有普遍的适用性,并在一定程度上可以帮助其提高融资水平以及现金流管理水平。

关键词：现金流管理建筑公司财务管理

Evaluation of Estrogenic Activity and Measurement of EDCs in Wastewater Treatment Plants

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Journal of Ocean University of China 2006年第4期5卷 351-356页

作者： B. C. lee J. Y. Jung H. K. Kim Environment & Process Technology Division Korea Institute of Science and Technology Seoul 136-791 Korea Department of Environmental Engineering National Institute of Environment Research Gwangju 500-712 Korea

Correlations between estrogenic activity and DOC/UV260 ratio in wastewater treatment processes were investigated to propose a simple, reliable and comprehensive indicator for the presence of estrogenic substances. Contrary to this, when short-term bioassays such as the E-SCREEN, receptor binding and reporter gene expression assays are used for detecting estrogenic activity in the wastewater sample, they require a long time, at least a few days. The major factors contributing to the estrogenic activity were found to be 17β-estradiol （E2） and estrone （El）. A good relationship between the DOC/ UV260 ratio and the concentration of estrogens （El and E2） in the effluent of the activated sludge process was found： the E2 concentration increased as the DOC/UV260 ratio increased while the E1 concentration decreased. The relative estrogenic activity and DOC/UV260 ratio showed a good correlation （R^2 = 0.84） for all sewage samples except the ozonized samples in the sewage treatment plants. This study shows that the estrogenic compounds are hard to be mineralized by the conventional biological processes. Advanced oxidation processes are required to further remove estrogenic substances in the secondary effluent. By analysis of DOC and UV260, the estrogenic activity in the wastewater can be rapidly estimated.

关键词： activated sludge process estrogenic substances 17β-estradiol Estrone DOC/UV260

牛膝活性成分β-蜕皮甾酮通过Akt信号干预地塞米松诱导的骨细胞凋亡

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中国骨质疏松杂志 2019年第3期25卷 375-379页

作者：魏元基李峻昊王利波王成龙戴薇薇上海中医药大学附属龙华医院上海200032

目的探讨牛膝活性成分β-蜕皮甾酮对地塞米松诱导MLO-Y4骨样细胞凋亡的抑制作用及其可能的作用机制。方法 10μmol/L地塞米松(dexamethasone,Dex)作用于MLO-Y4骨样细胞,以PI3K/Akt抑制剂LY294002为对照,β-蜕皮甾酮(β-Ecdysone,β-Ecd... 详细信息

目的探讨牛膝活性成分β-蜕皮甾酮对地塞米松诱导MLO-Y4骨样细胞凋亡的抑制作用及其可能的作用机制。方法 10μmol/L地塞米松(dexamethasone,Dex)作用于MLO-Y4骨样细胞,以PI3K/Akt抑制剂LY294002为对照,β-蜕皮甾酮(β-Ecdysone,β-Ecd)干预,分为6组:①正常组;②10μmol/L Dex模型组;③10μmol/L Dex+10μmol/Lβ-Ecd组;④10μmol/L Dex+10μmol/Lβ-Ecd+50μmol/L LY294002组;⑤10μmol/L Dex+0.1μmol/Lβ-Ecd组;⑥10μmol/L Dex+0.1μmol/Lβ-Ecd+50μmol/L LY294002组。作用48 h后,Annexin V-FITC/PI法检测细胞早期凋亡率,Western-Blot检测Akt1、Phospho-Akt(Thr308)、Connexin43(CX43)、Caspase9、Bad、Phospho-Bad蛋白表达。结果与正常组比较,Dex组细胞凋亡率升高,Caspase9、Bad蛋白表达升高,Akt1、CX43蛋白表达降低;与造模组比较,β-Ecd减弱Caspase9蛋白表达,使Akt1、CX43蛋白表达增强;LY294002使Akt1、CX43蛋白表达明显减弱,而β-Ecd并不能使LY294002降低的Akt1蛋白表达升高。结论 0.1μmol/L、10μmol/Lβ-蜕皮甾酮可能通过Akt信号途径干预地塞米松诱导的骨细胞凋亡。

关键词： β-蜕皮甾酮地塞米松骨细胞凋亡 Akt