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Intense pulsed light‑ba.ed trea.ment for the improvement of symptoms in gla.coma pa.ients trea.ed with hypotensive eye drops

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Eye a.d Vision 2024年第2期10卷 12-21页

作者： jose maria.martinez‑de‑la.Ca.a.Ca.los Oribio‑Quinto a.mudena.Mila.s‑del‑Bosch Pila. perez‑Ga.cia.La.ra.Mora.es‑Ferna.dez Ja.ier Ga.cia.Bella.jose manuel Benitez‑del‑Ca.tillo Julia. Ga.cia.Feijoo Da.id P.Pinero Ophtha.mology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Depa.tment of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Depa.tment of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Ba.kground:Ocula. surfa.e disea.e in gla.coma pa.ients is a.significa.t ocula. co-morbidity tha. ca. a.fect 40%to 59%of these pa.ients *** current study wa. a.med a. eva.ua.ing the potentia. clinica. benefit of a. intense pulsed light(IPL)-ba.ed trea.ment in gla.comatous pa.ients with ocula. surfa.e disea.e due to prolonged hypotensive eyedrop *** our knowledge,this is the first series a.a.yzing the thera.eutic effect of this trea.ment option in this type of ***:This non-compa.a.ive prospective ca.e series study enrolled a.tota. of 30 gla.coma pa.ients ra.ging in a.e from 57 to 94 yea.s old a.d trea.ed with hypotensive eyedrops for yea.s with dry eye *** pa.ients received four sessions of IPL trea.ment using the Optima IPL system(Lumenis,Yoknea.,Isra.l)a.justed to the officia. optimized Lumenis *** in symptomatology,cornea. sta.ning,conjunctiva. hyperemia.non-inva.ive brea.-up time(NIBUT),tea. osmola.ity,tea. meniscus height(TMH),meiboscore a.d meibomia. gla.d expressibility wa. a.a.yzed a.ter ***:Sta.istica.ly significa.t reductions were observed a.ter IPL trea.ment in the symptomatology scores mea.ured with different questionna.res[ocula. surfa.e disea.e index(OSDI),sta.da.d pa.ient eva.ua.ion of eye dryness(SPEED)a.d symptom a.sessment questionna.re in dry eye(Sa.DE)]a. well a. with the visua. a.a.ogue sca.e(Pa. cha.ge in OSDI wa.−15.0±11.3.a.significa.t reduction wa. found a.ter trea.ment in the cornea. sta.ning score(Pa.significa.t reduction wa. found in tea. film meniscus height(P=0.012),a. well a. in tea. film osmola.ity(P=0.001).a.significa.t reduction wa. a.so found in meibomia. gla.d expressibility(P=0.003),cha.ging the percenta.e of gra.e 3 eyes from 44.4%before IPL to 17.2%a.ter ***:IPL thera.y combined with meibomia. gla.d expression(MGX)seems to be a. effective option to improve symptomatology in gla.comatous pa.ients with ocula. surfa.e disea.

关键词： Gla.coma Intense pulsed light Dry eye Meibomia. gla.ds

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Muscle strength deficits a.e a.socia.ed with low bone minera. density in young pedia.ric ca.cer survivors:The iBoneFIT project

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Journa. of Sport a.d Hea.th Science 2024年第3期13卷 419-427页

作者： a.dres marmol-perez jose J.Gil-Cosa.o Esther Uba.o-Guisa.o Fra.cisco J.Llorente-Ca.ta.ero Jua. Fra.cisco Pa.cua.-Gázquez Kirsten K.Ness Vicente martinez-Vizca.no Jona.a. r.ruiz Luis Gra.ia.marco Depa.tment of Physica. Educa.ion a.d Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Depa.tment of Epidemiology a.d Ca.cer Control St.Jude Children's Research HospitalMemphisTN 38105USA Depa.tment of Communica.ion a.d Educa.ion Loyola University AndalusiaSeville 41704Spain Biosa.ita.y resea.ch Institute ibs.GranadaGranada 18012Spain maimonides Biomedica. resea.ch Institute of Cordoba.IMIBIC) Cordoba 14004Spain CIBErOBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Depa.tment of Specific Dida.tics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pedia.ric a.d a.olescent hematology a.d oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Hea.th a.d Socia. resea.ch Center Universidad de Castilla-La ManchaCuenca 13001Spain

Ba.kground Pedia.ric ca.cer survivors a.e a. increa.ed risk of muscle wea.ness a.d low a.ea. bone minera. density(a.MD).However,the preva.ence of muscle strength deficits is not well documented,a.d the a.socia.ions of muscle strength with a.MD a.e unknown in this ***,this study a.med to investiga.e the preva.ence of upper-a.d lower-body muscle strength deficits a.d to exa.ine the a.socia.ions of upper-a.d lower-body muscle strength with a.e-,sex,a.d ra.e-specific a.MD Z-scores a. the tota. body,tota. hip,femora. neck,a.d lumba. *** This cross-sectiona. study included 116 pedia.ric ca.cer survivors(12.1±3.3 yea.s old,mea.±SD;42.2%female).Upper-a.d lower-body muscle strength were a.sessed by ha.dgrip a.d sta.ding long jump test,***‑energy X‑ra. a.sorptiometry wa. used to mea.ure a.MD(g/cm2).a.socia.ions between muscle strength a.d a.MD were eva.ua.ed in multiva.ia.le linea. regression *** regression wa. used to eva.ua.e the contribution of muscle strength(1-decile lower)to the odds of ha.ing low a.MD(Z-score≤1.0).a.l a.a.yses were a.justed for time from trea.ment completion,ra.iothera.y exposure,a.d body mass *** More tha. one-ha.f of survivors were within the 2 lowest deciles for upper-(56.9%)a.d lower-body muscle strength(60.0%)in compa.ison to a.e-a.d sex-specific reference *** strength deficits were a.socia.ed with lower a.MD Z-scores a. a.l sites(B=0.133–0.258,p=0.001–0.032).Ea.h 1-decile lower in upper-body muscle strength wa. a.socia.ed with 30%–95%higher odds of ha.ing low a.MD Z-scores a. a.l *** 1-decile lower in lower-body muscle strength wa. a.socia.ed with 35%–70%higher odds of ha.ing low a.MD Z-scores a. tota. body,tota. hip,a.d femora. *** Muscle strength deficits a.e preva.ent in young pedia.ric ca.cer survivors,a.d such deficits a.e a.socia.ed with lower a.MD Z-scores a. a.l *** results suggest tha. interventions designed to improve muscle strength in t

关键词： Bone hea.th Childhood ca.cer DXA Lea. mass resista.ce tra.ning

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New thera.eutic stra.egy with extra.orporea. membra.e oxygena.ion for refra.tory hepa.opulmona.y syndrome a.ter liver tra.spla.t: a.ca.e report

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World Journa. of Tra.spla.ta.ion 2024年第1期14卷 210-214页

作者： Belinda.Sánchez Pérez maría.Pérez reyes jose a.a.da.Na.va.z Julio Sa.toyo Villa.ba.jose a.tonio perez Da.a.Cla.dia.Sa.chez-Gonza.ez Julio Sa.toyo-Sa.toyo Hepa.obilia.y a.d Tra.pla.ta.ion Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Depa.tment of Genera. a.d Digestive Surgery Regional University Hospital of MalagaMalaga 29010Spain

Ba.KGrOUND Due to the la.k of published litera.ure a.out trea.ment of refra.tory hepa.opulmona.y syndrome(HPS)a.ter liver tra.spla.t(LT),this ca.e a.ds information a.d experience on this issue a.ong with a.trea.ment with positive *** is a.complica.ion of end-sta.e liver disea.e,with a.10%-30%incidence in cirrhotic *** ca. reverse the physiopa.hology of this process a.d restore normal ***,in some ca.es,refra.tory hypoxemia.persists,a.d extra.orporea. membra.e oxygena.ion(ECMO)ca. be used a. a.rescue thera.y with good *** SUMmarY a.59-yea.-old pa.ient with a.cohol-rela.ed liver cirrhosis a.d porta. hypertension wa. included in the LT wa.ting list for *** ha. good liver function(Model for End-Sta.e Liver Disea.e score 12,Child-Pugh cla.s B7).He ha. pulmona.y fibrosis a.d a.mild restrictive respira.ory pa.tern with a.ba.a. oxygen sa.ura.ion of 82%.The macroa.grega.ed a.bumin test result wa.>*** demonstra.ed a.forced expira.ory volume in one second(FEV1)of 78%,forced vita. ca.a.ity(FVC)of 74%,FEV1/FVC ra.io of 81%,diffusion ca.a.ity for ca.bon monoxide of 42%,a.d ca.bon monoxide tra.sfer coefficient of 57%.He required domicilia.y oxygen a. 2 L/min(16 h/d).The pa.ient wa. a.mitted to the intensive ca.e unit(ICU)a.d extuba.ed in the first 24 h,needing high-flow thera.y a.d non-inva.ive ventila.ion a.d inha.ed nitric oxide *** wa. needed a.ter 72 *** to the non-response to supportive thera.ies,insta.la.ion of ECMO wa. decided with progressive recovery a.ter 9 *** wa. possible on the tenth da.,mainta.ning a.high-flow na.a. ca.nula.a.d de-esca.a.ing to conventiona. oxygen thera.y a.ter 48 *** wa. discha.ged from ICU on postopera.ive da.(POD)20 with a.90%-92%oxygen *** recycling wa. needed twice for a.ute *** pa.ient wa. discha.ged from hospita. on POD 27 with no symptoms,with a. 89%-90%oxygen *** Due to the fa.ora.le results observed,ECMO could bec

关键词： Liver tra.spla.ta.ion Hepa.opulmona.y syndrome refra.tory hypoxemia Trea.ment Extra.orporea. membra.e oxygena.ion Ca.e report

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Va.ia.ility a.d trends of nea.-surfa.e wind speed over the Tibeta. Pla.ea.:The role pla.ed by the westerly a.d a.ia. monsoon

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a.va.ces in Climate Cha.ge resea.ch 2024年第3期15卷 525-536页

作者： Ga.g-Feng ZHa.G Cesa. a.OrIN-MOLINa.Delia.g CHEN Tim rMCVICa. jose a.UIJa.rO Ka.-Qia.g DENG Lorenzo MINOLa.Ja.yeon LEE Seok-Woo SON Heng ma Pei-Jun SHI Sta.e Key La.ora.ory of Ea.th Surfa.e Processes a.d resource Ecology Beijing Normal UniversityBeijing 100875China Engineering Center of Desertifica.ion a.d Blown-Sa.d Control of Ministry of Educa.ion Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key La.ora.ory of Environmenta. Cha.ge a.d Na.ura. Disa.ter of Ministry of Educa.ion Beijing Normal UniversityBeijing 100875China Centro de Investiga.iones Sobre Desertifica.i'on Consejo Superior de Investigaciones Cientı'ficas(CIDECSIC-UV-Generalitat alenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain regiona. Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden CSIrO Environment CanberraACT 2600Australia a.stra.ia. resea.ch Council Centre of Excellence for Climate Extremes CanberraACT 2600Australia Sta.e Meteorologica. a.ency Balearic Islands OfficePalma de Mallorca 07015Spain School of a.mospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Interuniversity Depa.tment of regiona. a.d Urba. Studies a.d Pla.ning(DIST) Politecnico and University of TurinTurin 10125Italy School of Ea.th a.d Environmenta. Sciences Seoul National UniversitySeoul 08826South Korea a.mospheric a.d Ocea.ic Sciences Progra. Princeton UniversityPrinceton NJ 08544USA Geophysica. Fluid Dyna.ics La.ora.ory NOAAPrinceton NJ 08544USA

Nea.-surfa.e wind speed exerts profound impa.ts on many environmenta. issues,while the long-term(≥60 yea.s)trend a.d multideca.a. va.ia.ility in the wind speed a.d its underlying ca.ses in globa. high-eleva.ion a.d mounta.nous a.ea.(e.g.,Tibeta. Pla.ea.)r.ma.n la.gely ***,by exa.ining homogenized wind speed da.a.from 104 meteorologica. sta.ions over the Tibeta. Pla.ea. for 1961-2020 a.d Era. rea.a.ysis da.a.ets,we investiga.ed the va.ia.ility a.d long-term trend in the nea.-surfa.e wind speed a.d revea.ed the role pla.ed by the westerly a.d a.ia. *** results show tha. the homogenized a.nua. wind speed displa.s a.decrea.ing trend(-0.091 m s^(−1)per deca.e,prongest in spring(-0.131 m s^(−1)per deca.e,pa.d the wea.est in a.tumn(-0.071 m s^(−1)per deca.e,pre is a.distinct multideca.a. va.ia.ility of wind speed,which manifested in a. prominent increa.e in 1961-1970,a.susta.ned decrea.e in 1970-2002,a.d a.consistent increa.e in *** observed deca.a. va.ia.ions a.e likely linked to la.ge-sca.e a.mospheric circula.ion,a.d the correla.ion a.a.ysis unveiled a.more importa.t role of westerly a.d Ea.t a.ia. winter monsoon in modula.ing nea.-surfa.e wind cha.ges over the Tibeta. *** potentia. physica. processes a.socia.ed with westerly a.d a.ia. monsoon cha.ges a.e in concorda.ce with wind speed cha.ge,in terms of overa.l wea.ened horizonta. a.r flow(i.e.,geostrophic wind speed),declined vertica. thermal a.d dyna.ic momentum tra.sfer(i.e.,a.mospheric stra.ifica.ion thermal insta.ility a.d vertica. wind shea.),a.d va.ied Tibeta. Pla.ea. *** indica.es tha. to va.ying degrees these processes may ha.e contributed to the cha.ges in nea.-surfa.e wind speed over the Tibeta. *** study ha. implica.ions for wind power production a.d soil wind erosion prevention in the Tibeta. Pla.ea..

关键词： Tibeta. Pla.ea. Wind speed Deca.a. cha.ge a.mospheric circula.ion Physica. processes

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Tea.hers’ Perceptions of the Cha.lenges a.d Stra.egies in Supporting Students with rea.ing Difficulties

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Journa. of Contempora.y Educa.iona. resea.ch 2024年第8期8卷 238-252页

作者： Kristel P.a.ca.de ma.Leticia.jose C.Ba.ila. riza. College of Ta.l Taal BatangasBatangasPhilippines DepEd Ba.a.ga. Province BatangasPhilippines Ba.a.ga. Sta.e University BatangasPhilippines

The purpose of this study is to determine the tea.her’s perceptions of the cha.lenges a.d stra.egies in supporting students with rea.ing *** study used qua.ita.ive method of resea.ch a.d descriptive a.proa.h a. its resea.ch design,in a.dition to a.set of structured interview questions a.ministered through Google Forms to ga.her da.a.from elementa.y tea.hers of Ta.l Centra. School,loca.ed a. Ta.l *** structured interview questions were ca.efully designed to cover va.ious dimensions of the study,including the types of cha.lenges perceived by tea.hers,stra.egies employed,a.d possible solutions for a.dressing the problems encountered in the process of supporting students with rea.ing *** results revea.ed tha. tea.hers fa.ed severa. cha.lenges when tea.hing students with rea.ing difficulties such a. emotiona. a.d motiva.iona. issues/fa.tors,la.k of resources or tea.hing a.ds,deficits in knowledge a.d skills,a.d problems with student enga.ement a.d *** study a.so showed common a.proa.hes utilized by the tea.hers in supporting students with rea.ing difficulties,which were fostering a.positive a.d supportive environment,a.opting individua.ized a.d multifa.eted a.proa.hes,a.d utilizing effective tea.hing tools a.d ***,tea.hers a.so concluded va.ied solutions in a.dressing the cha.lenges perceived in tea.hing students with rea.ing difficulties towa.ds fostering rea.ing *** include developing peer support,use of positive reinforcement,a.d pa.enta. ***,specia.ized resources,professiona. development for tea.hers,a.d specific tea.hing stra.egies a.e a.so highlighted a. crucia. *** integra.ing these a.proa.hes,tea.hers concluded tha. it ca. crea.e a.supportive a.d effective lea.ning environment ta.lored to the needs of students with rea.ing difficulties.

关键词： rea.ing difficulties Supportive environment Positive reinforcement Pa.enta. involvement Professiona. development

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a.a.ysis of the role of Synta.tic Complexity in Students’ rea.ing Comprehension: a.Tea.her’s Perspective

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Journa. of Contempora.y Educa.iona. resea.ch 2024年第8期8卷 253-264页

作者： ma.Leticia.jose C.Ba.ila. Da.iel reds G.De Sa.un DepEd Ba.a.ga. Province BatangasPhilippines Ba.a.ga. Sta.e University BatangasPhilippines riza. College of Ta.l Taal BatangasBatangasPhilippines

This study exa.ines the role of the synta.tic complexity of the text in the rea.ing comprehension skills of *** the qua.ita.ive method of resea.ch,this pa.er used structured interview questions a. the main da.a.ga.hering *** la.gua.e tea.hers from Cora. na.Munti Na.iona. High School were selected a. the respondents of the *** of the study suggests tha. the synta.tic complexity of the text a.fects the rea.ing comprehension of the *** found it cha.lenging to understa.d the messa.e tha. the a.thor conveyed if he or she used a.la.ge number of phra.es a.d cla.ses in one ***,the complex sentence synta.tic structure wa. deemed the most cha.lenging for students to *** overcome sa.d cha.lenges in comprehending text,va.ious rea.ing intervention progra.s were utilized by *** interventions include focused or ta.geted instruction a.d the implementa.ion of the Project Dea.,suggested by the Depa.tment of *** progra.s were proven to help students improve their comprehension a. well a. their knowledge in synta.tica. structure of *** study underscores the importa.ce of selecting a.propria.e rea.ing materia.s a.d implementing suita.le rea.ing intervention progra.s to enha.ce students’comprehension skills.

关键词： rea.ing comprehension Synta.tic complexity rea.ing intervention progra. Synta.tic structure

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Environmenta. determina.ts of socia. wa.p diversity a.d a.sembla.e structure in a. a.0}zonia. a.chipela.ic la.dsca.e

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Zoologica. resea.ch(Diversity a.d Conserva.ion) 2024年第2期1卷 121-129页

作者： jose Victor a.ves Ferreira.a.exa.dre Somavilla.maíra.Benchimol a.a.Filipa.Pa.meirim Ca.los a.eres Da.ielle Storck-Tonon La.ora.ório de Ecologia.a.lica.a.a.Conserva.̧a.o Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Na.iona. de Pesquisa. da.a.0}zônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Progra. in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal School of Environmenta. Sciences University of East AngliaNorwich NR47TJUK Instituto Juruá Manaus69057-060Brazil Progr.ma.de Pós-Gra.ua.ão em a.biente e Sistemas de Produção a.rícola.PPGa.P) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower development ha. become a. importa.t driver of ha.ita. loss a.d fra.menta.ion a.ross lowla.d tropica. *** a.ple evidence on the detrimenta. effects of insula. ha.ita. fra.menta.ion on biodiversity,invertebra.e ta.a.tha. may be critica. to ecosystem functioning,ha.e been *** a.sessed the a.sembla.e-level responses of socia. wa.ps to forest insula.iza.ion induced by the Ba.bina.Hydroelectric Da. in Centra. Bra.ilia. *** mala.se tra.ping,we ca.tured wa.ps on 27 forest isla.ds a.d three continuous *** constructed Genera.ized Linea. Models a.d employed a.model selection a.proa.h to exa.ine the impa.t of loca. va.ia.les(fire severity(FIrE)a.d ba.a. a.ea.of pioneer tree species(PIONEEr))a.d la.dsca.e-sca.e va.ia.les(a.ount of ha.ita.(COVEr))on pa.terns of species richness,composition,a.d body size of wa.ps.a.tota. of 374 individua.s(29 species)were collected a.ross a.l sa.pling *** wa. the main predictor of species richness,while PIONEEr wa. the only va.ia.le tha. expla.ned va.ia.ion in community composition,with a.nega.ive effect on body *** results a.d evidence to the perva.ive impa.ts of la.ge hydroelectric da.s on tropica. forest biodiversity,a.d suggest tha. socia. wa.ps,a.ong other invertebra.es,ca. be used a. bioindica.ors in infra.tructure development projects.

关键词： Ha.ita. a.ount hypothesis Ha.ita. fra.menta.ion Ha.ita. loss Hydroelectric da.s Invertebra.es

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role of second look endoscopy in endoscopic submucosa. dissection a.d peptic ulcer bleeding:Meta.a.a.ysis of ra.domized controlled tria.s

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World Journa. of Ga.trointestina. Endoscopy 2024年第4期16卷 214-226页

作者： Gowtha.i Sa. Kogila.hota.Ja.irdha. jose a.dres perez a.sha. Ba.ga.ra.hta. K Qa.ba.r.ma. K Qa.ba.Ha.sha.Pa.tna.k Muha.mad Hussa.n Ya.inder Ba.ns Sa.im Sura.i Depa.tment of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Depa.tment of Medicine Saint Francis Health SystemsTulsaOK 74133United States Depa.tment of Interna. Medicine Sawai Man Singh Medical CollegeJaipur 302004India Depa.tment of Medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Depa.tment of Medicine Sher-i-kashmir Institute of Medical ScienceJammuSrinagar 190011India Depa.tment of Medicine Lady Hardinge Medical CollegeNew Delhi 110001India Depa.tment of Ga.troenterology Saint Michaels Medical CenterNewarkNJ 07102United States Depa.tment of Medicine a.d Pha.macology Texas AM UniversityCollege StationTX 77843United States

Ba.KGrOUND Second-look endoscopy(SLE)to prevent recurrent bleeding in pa.ients with peptic ulcer disea.e(PUD)a.d those undergoing endoscopic submucosa. dissection(ESD)is routinely being *** evidence exists rega.ding effica.y,risk,benefit,a.d *** To identify the role a.d effectiveness of SLE in ESD a.d PUD,a.socia.ed rebleeding a.d PUD-rela.ed outcomes like morta.ity,hospita. length of sta.,need for endoscopic or surgica. intervention a.d blood *** a.systematic review of litera.ure da.a.a.es PubMed,Cochra.e,a.d Emba.e wa. conducted from inception to Ja.ua.y 5,*** controlled tria.s tha. compa.ed pa.ients with SLE to those who did not ha.e SLE or eva.ua.ed the role of prophyla.tic hemosta.is during SLE compa.ed to other conserva.ive interventions were *** study wa. conducted per PrISma guidelines,a.d the protocol wa. registered in PrOSPErO(ID CrD42023427555:).revman wa. used to perform meta.a.a.ysis,a.d mantel-Ha.nszel Odds ra.io(Or)were genera.ed using ra.dom effect *** a.tota. of twelve studies with 2687 pa.ients were included in our systematic review a.d meta.a.a.ysis,of which 1074 pa.ients underwent SLE a.ter ESD a.d 1613 pa.ients underwent SLE a.ter PUD-rela.ed *** ESD,the ra.es of rebleeding were 7%in the SLE group compa.ed to 4.4%in the non-SLE group with Or 1.65,95%confidence interva.s(CI)of 0.96 to 2.85;P=0.07,wherea. it wa. 11%in the SLE group compa.ed to 13%in the non-SLE group with Or 0.895%CI:0.50 to 1.29;P=*** mea. difference in the blood tra.sfusion ra.es in the SLE a.d no SLE group in PUD wa. Or 0.01,95%CI:-0.22 to 0.25;P=*** SLE vs non-SLE groups with PUD,the Or for Endoscopic intervention wa. 0.29,95%CI:0.08 to 1.00;P=0.05 while it wa. Or 2.03,95%CI:0.95 to 4.33;P=0.07,for surgica. *** mea. difference in the hospita. length of sta. wa.-3.57 d between the SLE a.d no SLE groups in PUD with 95%CI:-7.84 to 0.69;P=0.10,denoting a. a.era.e of

关键词： Endoscopy Endoscopic submucosa. dissection Peptic ulcer Ga.trointestina. bleeding

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Corrigendum to'Ca.cer chemothera.y a.d beyond:Current sta.us,drug ca.dida.es,a.socia.ed risks a.d progress in ta.geted thera.eutics'[Genes&Disea.es 10(2023)1367-1401]

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Genes & Disea.es 2024年第4期11卷 426-427页

作者： Uttpa. a.a.d a.hijit Dey a.vind K.Singh Cha.del rupa.Sa.ya. a.0}rna.h Mishra.Devendra.Kumar Pa.dey Va.entina.De Fa.co a.un Upa.hya. ra.esh Ka.dimalla.a.upa.0} Cha.dha.y Ja.preet Ka.r Dha.ja. Sa.ka. Dewa.jee Ja.a.a.shmi Va.la.kondu jose M.perez de la.La.tra Depa.tment of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Depa.tment of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disea.e Biology a.d Integra.ive Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Depa.tment of Bota.y Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Fa.ulty of Science a.d Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Depa.tment of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology a.d Experimenta. Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Depa.tment of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSir-india. Institute of Chemica. Technology HyderabadTelangana 500007India Depa.tment of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Depa.tment of Computa.iona. Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India a.va.ced Pha.macognosy resea.ch La.ora.ory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Depa.tment of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of macromolecules resea.ch Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published a.ticle,there wa. a. error in the a.filia.ion information a.out the first a.thor Uttpa. a.a.d[a..Instea. of"Depa.tment of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva.84105,Isra.l",it should be"CytoGene resea.ch&Development LLP,K-51,UPSIDa.Industria. a.ea.Kursi roa.(Lucknow),***,225001,Utta. Pra.esh,India..The a.thors would like to a.ologize for a.y inconvenience ca.sed a.d sta.e tha. this does not cha.ge the scientific conclusions of thea.ticle ina.ywa..

关键词： Ca.cer Cor ta.geted

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Integra.ion a.d implementa.ion of precision medicine in the multifa.eted infla.matory bowel disea.e

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世界胃肠病学杂志:英文版 2023年第36期29卷 5211-5225页

作者： Gowtha.i Sa. Kogila.hota.Ja.irdha. jose a.dres perez a.drea.Belen perez Sa.im Sura.i Depa.tment of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Depa.tment of Medicine Saint Francis Health SystemsTulsaOK 74133United States Depa.tment of resea.ch Columbia UniversityNew YorkNY 10027United States Depa.tment of Medicine a.d Pha.macology Texas A&M UniversityCollege StationTX 77413United States

Infla.matory bowel disea.e(IBD)is a.complex disea.e with va.ia.ility in genetic,environmenta.,a.d lifestyle fa.tors a.fecting disea.e presenta.ion a.d *** medicine ha. the potentia. to pla. a.crucia. role in mana.ing IBD by ta.loring trea.ment pla.s ba.ed on the heterogeneity of clinica. a.d tempora. va.ia.ility of *** medicine is a.popula.ion-ba.ed a.proa.h to mana.ing IBD by integra.ing environmenta.,genomic,epigenomic,tra.scriptomic,proteomic,a.d meta.olomic *** is a.recent a.d ra.idly developing *** widesprea. a.option of precision medicine worldwide ha. the potentia. to result in the ea.ly detection of disea.es,optimal utiliza.ion of hea.thca.e resources,enha.ced pa.ient outcomes,a.d,ultimately,improved qua.ity of life for individua.s with *** precision medicine is promising in terms of better qua.ity of pa.ient ca.e,ina.equa.ies exist in the ongoing *** is discorda.ce in study conduct,a.d da.a.collection,utiliza.ion,interpreta.ion,a.d *** review a.ms to describe the current litera.ure on precision medicine,its multiomics a.proa.h,a.d future directions for its a.plica.ion in IBD.

关键词： Precision medicine Multiomics Infla.matory bowel disea.e Crohn’s disea.e Ulcera.ive colitis Da.a.integra.ion

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