Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project
作者机构：Department of Physical Education and SportsFaculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer ControlSt.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and EducationLoyola University AndalusiaSeville 41704Spain Biosanitary Research Instituteibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC)Cordoba 14004Spain CIBEROBNBiomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific DidacticsFaculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology servicePediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research CenterUniversidad de Castilla-La ManchaCuenca 13001Spain
出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)
年 卷 期：2024年第13卷第3期
页 面：419-427页
核心收录：
学科分类：0403[教育学-体育学] 1202[管理学-工商管理] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：support by the Spanish Ministry of Science and Innovation(Ref:PID2020-117302RA-I00) La Caixa Foundation(Ref:LCF/BQ/PR19/11700007) the University of Granada Plan Propio de Investigación 2021-Excellence actions:Unit of Excellence on Exercise,Nutrition,and Health(UCEENS)and by CIBEROBN,Centro de Investigación Biomédica en Red(CB22/3/00058) Instituto de Salud Carlos III,Ministerio de Ciencia e Innovación and Unión Europea-European Regional Development Fund AMP was also recipient of a predoctoral fellowship(FPU20/05530)by the Spanish Ministry of Education,Culture and Sport EUG was supported by the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea-NextGenerationEU
主 题：Bone health Childhood cancer DXA Lean mass Resistance training
摘 要：Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t
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