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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： jie Pang Lin-Yan qian Ping Lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

Reversible Mn^(2+)/Mn^(4+)double-electron redox in P3-type layer-structured sodium-ion cathode

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Journal of Energy Chemistry 2024年第2期89卷 79-88,I0004页

作者： jie Zeng Jian Bao Ya Zhang Xun-Lu Li Cui Ma Rui-jie Luo Chong-Yu Du Xuan Xu Zhe Mei Zhe qian Yong-Ning Zhou Department of Materials Science Fudan UniversityShanghai 200433China Shanghai Xuanyi New Energy Development Co. LtdShanghai 201800China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai 200240China

The balance between cationic redox and oxygen redox in layer-structured cathode materials is an important issue for sodium batteries to obtain high energy density and considerable cycle *** redox can contribute extra capacity to increase energy density,but results in lattice instability and capacity fading caused by lattice oxygen gliding and oxygen *** this work,reversible Mn^(2+)/Mn^(4+)redox is realized in a P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)cathode material with high specific capacity and structure stability via Co *** contribution of oxygen redox is suppressed significantly by reversible Mn^(2+)/Mn^(4+)redox without sacrificing capacity,thus reducing lattice oxygen release and improving the structure *** X-ray techniques reveal that P3 phase is well maintained in a wide voltage window of 1.5-4.5 V ***^(+)/Na even at 10 C and after long-term *** is disclosed that charge compensation from Co/Mn-ions contributes to the voltage region below 4.2 V and O-ions contribute to the whole voltage *** synergistic contributions of Mn^(2+)/Mn^(4+),Co^(2+)/Co^(3+),and O^(2-)/(O_n)^(2-)redox in P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)lead to a high reversible capacity of 215.0 m A h g^(-1)at 0.1 C with considerable cycle *** strategy opens up new opportunities for the design of high capacity cathode materials for rechargeable batteries.

关键词： Sodium batteries Cathode materials Layered structure Co substitution

Construction of core@double-shell structured energetic composites with simultaneously enhanced thermal stability and safety performance

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Defence Technology（防务技术） 2024年第4期34卷 134-142页

作者： Peng Wang Wen qian Ruolei Zhong Fangfang He Xin Li jie Chen Li Meng Yinshuang Sun Guansong He Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China State Key Laboratory of Environment-friendly Energy Materials School of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China

The poor thermal stability and high sensitivity severely hinder the practical application of hexanitrohexaazaisowurtzitane(CL-20).Herein,a kind of novel core@double-shell CL-20 based energetic composites were fabricated to address the above *** coordination complexes which consist of natural polyphenol tannic acid(TA) and Fe~Ⅲ were chosen to construct the inner shell,while the graphene sheets were used to build the outer *** resulting CL-20/TA-Fe~Ⅲ/graphene composites exhibited simultaneously improved thermal stability and safety performance with only 1 wt% double-shell content,which should be ascribed to the intense physical encapsulation effect from inner shell combined with the desensitization effect of carbon nano-materials from outer *** phase transition(ε to γ) temperature increased from 173.70 ℃ of pure CL-20 to 191.87℃ of CL-20/TA-Fe~Ⅲ/graphene ***,the characteristic drop height(H_(50)) dramatically increased from 14.7 cm of pure CL-20 to112.8 cm of CL-20/TA-Fe~Ⅲ/graphene composites,indicating much superior safety performance after the construction of the double-shell *** general,this work has provided an effective and versatile strategy to conquer the thermal stability and safety issues of CL-20 and contributes to the future application of high energy density energetic materials.

关键词： CL-20 Double-shell structure Thermal stability Safety performance Tannic acid Graphene sheets

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二联体亲子鉴定罕见案例分析及应对策略

西南医科大学学报 2024年第3期47卷 231-235页

作者：郭侃付杰文宋炳辉钱捷罗章成竞梁何涛傅俊江西南医科大学医学基础研究中心表观遗传与肿瘤四川省高校重点实验室泸州646000 西南医科大学司法鉴定中心DNA法医物证实验室泸州646000

目的对亲子鉴定中二联体罕见案例进行分析并给出应对策略。方法对罕见案例样本进行DNA提取,使用AGCU EX-22试剂盒进行二联体和三联体检测;使用阅微基因36A试剂盒进行二联体检测。通过遗传测序仪进行电泳分析,GeneMapper ID-X软件进行数... 详细信息

目的对亲子鉴定中二联体罕见案例进行分析并给出应对策略。方法对罕见案例样本进行DNA提取,使用AGCU EX-22试剂盒进行二联体和三联体检测;使用阅微基因36A试剂盒进行二联体检测。通过遗传测序仪进行电泳分析,GeneMapper ID-X软件进行数据分析得到短串联重复序列(short tandem repeats,STR)图谱和相应的基因座数据,并计算其累积亲权指数。结果采用AGCU EX-22试剂盒进行被检父和孩子二联体鉴定,获得累积亲权指数为7.0516×10^(2),这个值既大于0.0001又小于10000。根据《亲权鉴定技术规范》(GB/T 37223-2018),其结果是既不支持、又不能排除被检父为孩子的生物学父亲,不能出具明确的鉴定意见;增加孩子母亲样本,改为三联体鉴定后,使用相同的试剂盒进行鉴定,获得的累积亲权指数为2.6327×10^(8),大于10000,支持被检父为孩子的生物学父亲。与此同时,增加STR基因座位点,使用阅微基因36A试剂盒进行被检父和孩子的二联体鉴定,获得累积亲权指数为1.0378×10^(9),同样大于10000,亦能出具明确的鉴定意见。结论在二联体亲子鉴定中,通过增加孩子生母做三联体亲子鉴定或者是增加STR位点进行检测,都能提高累积亲权指数,帮助罕见疑难亲子鉴定案例出具明确的鉴定意见。

关键词：短串联重复序列二联体亲权鉴定三联体亲权鉴定累积亲权指数

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基于数字化转型的医院后勤“一站式”报修管理研究与实践

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中国医院建筑与装备 2024年第6期25卷 18-22页

作者：金永春徐云华钱杰许天钺徐俊陈红张之薇上海市胸科医院上海200030

随着智慧医院建设的日益深入,医院后勤成为智慧医院建设的重要组成部分,越来越多的医院开始建立并应用后勤报修信息化系统,然而系统的应用效果参差不齐。该文介绍了上海市胸科医院后勤“一站式”报修服务工作及管理经验,针对“一站式”... 详细信息

随着智慧医院建设的日益深入,医院后勤成为智慧医院建设的重要组成部分,越来越多的医院开始建立并应用后勤报修信息化系统,然而系统的应用效果参差不齐。该文介绍了上海市胸科医院后勤“一站式”报修服务工作及管理经验,针对“一站式”报修服务中出现的医护人员自我报修率低下、报修定位不准、服务商响应积极性不高等问题,通过设置报修位置码、拓展报修范围、升级报修系统、主动预防巡检等措施,持续改进后勤服务质量和效率,更好地满足现代化医院高效、便捷、人性化的管理需求。

关键词：智慧医院后勤管理报修位置码一站式一体化管理

Local aneurysmal dilatation mimicking stent malapposition and concurrent vulnerable plaque within neointima of normal lumen after drug-eluting stent implantation： primary new findings from optical coherence tomography

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Chinese Medical Journal 2012年第6期125卷 1186-1188页

作者： GUO Yuan-lin YANG Yue-jin GAO Zhan qian jie Clinical and Research Center for Coronary Disease Fu Wai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Very late stent thrombosis is a life-threatening complication of implantation of drug-eluting stent （DES）. The mechanisms are still unidentified. Stent malapposition is supposed to be one debated reason. Here we report a case of 33 months after DES implanted. Observed by optical coherence tomography, we detected a lipid-rich plaque with defective fibrous cap within the neointima and many local aneurysmal dilatations between stent struts, which mimic ＂malapposition＂ on the angiogram. These indicated that vulnerable plaque hidden in the neointima at the stent segment might be a potential mechanism of very late stent thrombosis after DES implantation.

关键词： drug-eluting stent stent malapposition vulnerable plaque optical coherence tomography

Rational Design of Organelle-Targeted Fluorescent Probes:Insights from Artificial Intelligence

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Research 2023年第3期2023卷 769-779页

作者： jie Dong jie qian Kunqian Yu Shuai Huang Xiang Cheng Fei Chen Hualiang Jiang Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083P.R.China National Engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004P.R.China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203P.R.China

Monitoring the physiological changes of organelles is essential for understanding the local biological information of cells and for improving the diagnosis and therapy of ***,fluorescent probes are considered as the most powerful tools for imaging and have been widely applied in biomedical ***,the expected targeting effects of these probes are often inconsistent with the real *** design of fluorescent probes mainly depends on the empirical knowledge of researchers,which was inhibited by limited chemical space and low ***,we proposed a novel multilevel framework for the prediction of organelle-targeted fluorescent probes by employing advanced artificial intelligence *** this way,not only the targeting mechanism could be interpreted beyond intuitions but also a quick evaluation method could be established for the rational ***,the targeting and imaging powers of the optimized and synthesized probes based on this methodology were verified by quantitative calculation and experiments.

关键词： inhibited diagnosis Probe

日常生活中的教育知识:衔接教育生命时序的可能路径

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中国教育学刊 2020年第10期 71-76页

作者：钱洁南京师范大学教育科学学院江苏南京210097

家庭教育遵循学校教育发展的普遍性逻辑,注重对知识确定性的追寻,失却"现象学事实"的引导,使其日渐脱离日常生活。日常生活中的教育知识拓展了教育知识的内涵,有助于走出"已知者"和"不知者"的二元对立,可以成为学校教育和家庭教育共享... 详细信息

家庭教育遵循学校教育发展的普遍性逻辑,注重对知识确定性的追寻,失却"现象学事实"的引导,使其日渐脱离日常生活。日常生活中的教育知识拓展了教育知识的内涵,有助于走出"已知者"和"不知者"的二元对立,可以成为学校教育和家庭教育共享的知识基础。立足日常生活并超越日常生活,处理好知与识、教与育、知与行、家与校的关系,为走出学校教育与家庭教育分割的局面,衔接教育的生命时序寻找了可能路径。

关键词：学校教育家庭教育日常生活教育知识

西西弗及其他——对于“超越性”的一种文化反思

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现代哲学 2006年第6期 66-72页

作者：钱捷南开大学哲学系天津300071

存在主义作家伽缪在其《西西弗的神话》中通过“背谬”概念表达了对于人的存在意义的反思。这一意义体现于人的有限性和其完美与大全的理念(超越性)之间无法消解的张力。该文在确定这一点的同时,指出了这种背谬意识是西方文化隐密的本质... 详细信息

存在主义作家伽缪在其《西西弗的神话》中通过“背谬”概念表达了对于人的存在意义的反思。这一意义体现于人的有限性和其完美与大全的理念(超越性)之间无法消解的张力。该文在确定这一点的同时,指出了这种背谬意识是西方文化隐密的本质,也是其异于中国传统文化的深层根据。

关键词：伽缪背谬超越性西方文化中国传统文化