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DeepSun:machine-learning-as-a-service for solar flare prediction

Research in Astronomy and Astrophysics 2021年第7期21卷 51-61页

作者： Yasser Abduallah jason t.l.wang Yang Nie Chang liu Haimin wang Institute for Space Weather Sciences New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA Department of Computer Science New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA Big Bear Solar Observatory New Jersey Institute of Technology40386 North Shore LaneBig Bear CityCA 92314-9672USA Center for Solar-terrestrial Research New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102-1982USA

Solar flare prediction plays an important role in understanding and forecasting space *** main goal of the Helioseismic and Magnetic Imager(HMI), one of the instruments on NASA's Solar Dynamics Observatory, is to study the origin of solar variability and characterize the Sun's magnetic *** provides continuous full-disk observations of the solar vector magnetic field with high cadence data that lead to reliable predictive capability;yet, solar flare prediction effort utilizing these data is still limited. In this paper, we present a machine-learning-as-a-service(Mlaa S) framework, called Deep Sun,for predicting solar flares on the web based on HMI's data products. Specifically, we construct training data by utilizing the physical parameters provided by the Space-weather HMI Active Region Patch(SHARP)and categorize solar flares into four classes, namely B, C, M and X, according to the X-ray flare catalogs available at the National Centers for Environmental Information(NCEI). thus, the solar flare prediction problem at hand is essentially a multi-class(i.e., four-class) classification problem. the Deep Sun system employs several machine learning algorithms to tackle this multi-class prediction problem and provides an application programming interface(API) for remote programming users. to our knowledge, Deep Sun is the first Mlaa S tool capable of predicting solar flares through the internet.

关键词： Sun:flares Sun:activity methods:data analysis

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卫星和地基遥感观测资料约束下的核-壳态气溶胶光学特性模拟研究

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光学学报 2024年第6期44卷 329-340页

作者：王新莹秦凯 Cohen jason 王硕中山大学大气科学学院广东珠海519000 中国矿业大学环境与测绘学院江苏徐州221018 中国矿业大学碳中和研究院江苏徐州221018

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用tROPOMI卫星紫外波段观测数据与AERONEt地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,... 详细信息

针对结合星地观测与模型定量模拟消光性气溶胶光学特性及黑碳质量空间分布这一热点问题,利用tROPOMI卫星紫外波段观测数据与AERONEt地基观测数据,基于“核-壳”假设下的米散射模型提出了一种准确量化黑碳气溶胶质量空间分布的模拟方法,并对北京、中国香港、首尔三个站点的模拟结果进行分析与验证。多源数据约束后米散射模型模拟得到的结果显示:北京的吸收系数在0.04~0.13之间,中国香港的吸收系数整体小于0.08,首尔的吸收系数介于0.02~0.06之间。计算得到的黑碳气溶胶柱内质量空间分布结果显示:北京站黑碳气溶胶柱内质量在200~600 kg/grid之间,中国香港站黑碳气溶胶柱内质量在180~650 kg/grid之间,首尔站黑碳气溶胶柱内质量在300 kg/grid以下。结合卡尔曼滤波排放清单与一阶箱模型对黑碳气溶胶柱内质量结果进行间接验证,计算得到的黑碳气溶胶生命周期为1~4 d不等,符合其在大气中的真实状态,说明结果具有一定可靠性。通过对比加入tROPOMI紫外波段卫星观测数据前后对模型进行约束得到的粒径分布及吸收系数结果的差异发现:加入紫外波段观测数据对模拟结果具有一定增强作用。所提方法模拟结果良好,方案具有一定应用潜力。

关键词： tROPOMI卫星数据 AERONEt 黑碳气溶胶米散射模型

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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui wang Annie wang Zander Schwartz Jeffrey Hong lily Song William Wagstaff Rex C.Haydon Hue H.luu Sherwin H.Ho jason Strelzow Russell R.Reid tong-Chuan He lewis l.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and lRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen tan lingwa wang Yifan Yang Shizhi He George G.Chen jason YK.Chan Michael CF.tong C.A.van Hasselt Wenbin Xu ling Feng Ru wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

locoregionally advanced laryngeal and hypopharyngeal cancers(lA-lHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)the use of induction chemotherapy(IC)as a larynxpreserving approach for lA-lHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(linum l.)

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Oil Crop Science 2024年第2期9卷 121-130页

作者： Kenyon J. Nisbett Abida Alokozai Su Hyun Elizabeth Ko G. Adam Mott jason C.l. Browna Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&Systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome Evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular *** present study evaluated this hypothesis using annual and perennial flax(linum l.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using *** chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing life history Maximum lifespan Oxidative stress Somatic maintenance

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the evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie wang Yonghui wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.luu Sherwin Ho Michael J.lee jason Strelzow Russell R.Reid tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

the evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells targeted therapy Wnt signaling

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唐君毅的和合思维

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孔学堂 2024年第1期11卷 1-13,110-122页

作者：蔡家和 jason t.Clower(译) 台湾东海大学哲学系中国台湾台中40766 California State University Chico

唐君毅先生学识渊博,对于中、西、印学皆有一定程度的研究。而他的个性圆融,在面对历史上各家或学派论争时,大多不会去评判各派的高低或对错,而是看出各家专长所在,各给出一个位子。此近似郭象之圆教观,所谓的各美其美!唐先生此一和合... 详细信息

唐君毅先生学识渊博,对于中、西、印学皆有一定程度的研究。而他的个性圆融,在面对历史上各家或学派论争时,大多不会去评判各派的高低或对错,而是看出各家专长所在,各给出一个位子。此近似郭象之圆教观,所谓的各美其美!唐先生此一和合态度与圆融思想,除了是他个性使然,亦与他涵泳于中华文化而深得其味有关,诸如华严宗的一多相即、相摄相入;《庄子·天下篇》道术之六通四辟、无乎不在,以及《中庸》的中和思想、万物并育而不相害等精神,在滋养其非凡卓识与感通精神——其卓识要去创辟天地之包容,其感通要去持应万物之共谐,从而圆成唐先生心中华夏文化之谐和天地。

关键词：和合圆融分别唐君毅相摄相入

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.loh tuck Wah Soong jason K.W.lee Ivan C.C.low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and technological Enterprise(CREAtE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(t_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(t_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:t_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in t_(re).With the development of hyperthermia,t_(br)increases and dovetails with the rising t_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(t_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both t_(re)and t_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates t_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHt- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： jason Philip Appleton lisa J Woodhouse Craig S Anderson Sandeep Ankolekar lesley Cala Mark Dixon timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall thompson G Robinson Christine Roffe Else C Sandset Jeffrey l Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia the George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background the effect of transdermal glyceryl trinitrate(GtN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GtN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke trial-2(RIGHt-2).Methods RIGHt-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GtN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GtN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GtN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS AlREADY KNOWN ON tHIS tOPIC⇒transdermal glyceryl trinitrate(GtN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason lynch Christopher E.Stevens Christopher Munley Chentao li Jin Hou Hao Zhang Andrew torma thomas Darlington Francis Coen Kevin li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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