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Randomized Clinical Trials of Traditional Chinese Medicines for Treating Ulcerative Colitis:A Scoping Review

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World Journal of Traditional Chinese Medicine 2021年第3期7卷 326-331页

作者： You-You Zheng Xiao Wang jiang-Tao Si yu-Xin Sun Wen-Bin Hou jian-Ping Liu yuan-Xi Li Zhao-Lan Liu Center for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Special Treatment Center Wang Jing Hospital of Chinese Academy of Traditional Chinese Medicine College of Statistics and Data Science Faculty of ScienceBeijing University of TechnologyBeijing 100124China

Objective:Traditional Chinese medicines(TCMs)are efficacious against ulcerative colitis(UC).In recent years,the number of randomized clinical trials(RCTs)of TCM has ***,it is very important to summarize the basic characteristics,quality,and types of TCM interventions in published *** scoping review was performed to systematically identify and describe the current situations about RCTs of TCMs for treating *** to express the focus and specifics of nowadays research in TCM interventions in RCTs and evaluate their common disadvantages exposed to help advance in TCM *** and Methods:A scoping review was conducted according to the PRISMA extension for scoping *** searched two English databases and four Chinese databases from the date of establishment of each database to January *** from RCTs focusing on any TCM treatment for patients with UC were extracted and *** and characterization were performed by two independent reviewers using predefined *** discrepancies were resolved by consensus discussion with a third *** Excel 2010 was used to extract the following data from the included studies:(1)basic information of the included studies including research ID,article title,publication language,journal,year of publication,and funding information;(2)patient information including gender,age,disease course,disease stage,severity,sample size;and(3)information on intervention measures,types of intervention measures,drug dosage forms,and treatment ***:The search identified 2225 RCTs published between1987 and *** studies covered 36 provinces in *** time frame of the RCTs was<28 days in approximately one-third of the RCTs(647,29.08%).Only one RCT was published in *** three-quarters of RCTs(1665,74.83%)did not report the severity of the *** types of interventions were included in the RCTs:pharmacotherapy(2028,91.15%),nonpharmacotherapy(57,2.56%),and a

关键词： Dosage forms randomized clinical trial research status scoping review Traditional Chinese medicine ulcerative colitis

Loss of micro RNA-124 expression in neurons in the peri-lesion area in mice with spinal cord injury

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Neural Regeneration Research 2015年第7期10卷 1147-1152页

作者： yu Zhao Hui Zhang Dan Zhang Cai-yong yu Xiang-hui Zhao Fang-fang Liu Gan-lan Bian Gong Ju jian Wang Department of Anatomy Hebei North University Department of Stomatology the First Hospital of Zhangjiakou Institute of Neurosciences the Fourth Military Medical University

Micro RNA-124（mi R-124） is abundantly expressed in neurons in the mammalian central nervous system, and plays critical roles in the regulation of gene expression during embryonic neurogenesis and postnatal neural differentiation. However, the expression profile of mi R-124 after spinal cord injury and the underlying regulatory mechanisms are not well understood. In the present study, we examined the expression of mi R-124 in mouse brain and spinal cord after spinal cord injury using in situ hybridization. Furthermore, the expression of mi R-124 was examined with quantitative RT-PCR at 1, 3 and 7 days after spinal cord injury. The mi R-124 expression in neurons at the site of injury was evaluated by in situ hybridization combined with Neu N immunohistochemical staining. The mi R-124 was mainly expressed in neurons throughout the brain and spinal cord. The expression of mi R-124 in neurons significantly decreased within 7 days after spinal cord injury. Some of the neurons in the peri-lesion area were Neu N＋/mi R-124-. Moreover, the neurons distal to the peri-lesion site were Neu N＋/mi R-124＋. These findings indicate that mi R-124 expression in neurons is reduced after spinal cord injury, and may reflect the severity of spinal cord injury.

关键词： nerve regeneration spinal cord injury micro RNA spinal cord in situ hybridization immunohistochemistry digoxin Neu N protein brain neural plasticity repair apoptosis NSFC grants neural regeneration

Intravascular ultrasound-based analysis of factors affecting minimum lumen area in coronary artery intermediate lesions

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Journal of Geriatric Cardiology 2016年第2期13卷 169-174页

作者： jian LIU Ying ZHANG Wei-Min WANG Zhao WANG Qi LI Chuan-Fen LIU yu-Liang MA Ming-yu LU Hong ZHAO Department of Cardiology Peking University People's Hospital Beijing China

Objective To identify clinical characteristics associated with the minimum lumen area （MLA） of proximal or middle intermediate lesions in the left anterior descending （LAD） artery, and to develop a model to predict MLA. Methods We retrospectively analyzed demographic data, medical history, and intravascular ultrasound findings for 90 patients with intermediate lesions in the LAD artery. Linear regression was used to identify factors affecting MLA, and multiple regression was used to develop a model for predicting MLA. Results Age, number of lesions, and diabetes mellitus correlated significantly with MLA of proximal or middle intermediate lesions. A regression model for predicting MLA （mm2） was derived from the data： 7.00 - 0.05 × （age） - 0.50 × （number of lesions）. A cut-off value of 3.1 mm2 was proposed for deciding when to perform percutaneous coronary intervention. Conclusion This model for predicting MLA of proximal or middle intermediate lesions in the LAD artery showed high accuracy, sensitivity, and specificity, indicating good diagnostic potential.

关键词： Intermediate lesions Intravascular ultrasound Predictive model Risk factors

In vitro corrosion behavior and cytotoxicity property of magnesium matrix composite with chitosan coating

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Journal of Central South University 2015年第3期22卷 829-834页

作者：戴翌龙余琨陈良建陈畅乔雪岩颜阳 School of Materials Science and Engineering Central South University State Key Laboratory of Powder Metallurgy (Central South University) Xiang Ya Third Hospital Central South University

Mg-6%Zn-10%β-Ca3(PO4)2 composite was prepared through powder metallurgy methods with different chitosan coatings on its surface. The properties of the chitosan coatings on the surface of Mg-6%Zn-10%β-Ca3(PO4)2 composite, such as the adhesion ability, the corrosion behavior and the cytotoxicity properties, were investigated, and the microstructure of the chitosan coating was observed by scanning electron microscope(SEM). The results show that chitosan coating improves the corrosion resistance of the magnesium composite specimens significantly. Mg-6%Zn-10%β-Ca3(PO4)2 composite specimens exhibit good corrosion resistance and low p H values in simulated body fluid(SBF) at 37 °C in the immersion test with 7-layer chitosan coating whose relative molecular mass is 30×104 Da. The cytotoxicity tests indicate that Mg-6%Zn-10%β-Ca3(PO4)2 with chitosan coating is nontoxic with a cytotoxicity grade of zero against L-929 cells, which is better than that of uncoated composites.

关键词： magnesium matrix composite chitosan coating in vitro test cytotoxicity

OPG inhibits gene expression of RANK and CAⅡ in mouse osteoclast-like cell

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OPG inhibits gene expression of RANK and CAⅡ in mouse osteo...

中国康复医学会第十二届全国运动疗法学术大会

作者： jian Chen jian-Quan He Shu-yu Zhen li-Qun Huang Department of Rehabilitation Zhong Shang HospitalXiamen University Department of Rehabilitation Wuhan General Hospital of Guangzhou Military General Hospital

This study was designed to determine the effects of the osteoprotegerin（OPG） on the mRNA expression of carbonic anhydrase II（CAII） and the receptor activator of NF-κB（RANK） in mouse osteoclast-like *** cells were harvested from femora and tibiae of mouse,and cultured in 6-well chamber *** 1day of incubation,the marrow cells were exposed to M-CSF（25ng/ml）,RANKL（50ng/ml） and different concentrations of OPG（50ng/ml,75 ng/ml and 100ng/ml,respectively） for 3 ***-like cells were confirmed by both tartrate resistant acid phosphatase（TRAP） stain and bone resorption *** expression of RANK and CAIImRNA was determined with real-time fluorescent quantitative polymerase chain *** numbers of multinucleated,TRAP-positive osteoclast-like cells and resorption pits formed were *** with the M-CSF+RANKL group,RANKmRNA expression were statistically decreased in the M-CSF and M-CSF+RANKL+OPG（100ng/ml） groups（P = 0.004,P = 0.024,respectively）;Compared with the M-CSF,M-CSF+RANKL and M-CSF+RANKL+OPG（100ng/ml）group,CAIImRNA expression in the M-CSF+RANKL+OPG（75ng/ml） groups were statistically decreased（P = 0.001,P = 0.008,and P = 0.036,respectively）.These data suggest that OPG could regulate the expression of RANK and CA II mRNA in the marrow culture system.

关键词： Osteoclast-like cell OPG RANKL RANKmRNA CAⅡmRNA

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椭圆空气孔微结构光纤限制损耗的分析

物理学报 2007年第2期56卷 946-951页

作者：王健雷乃光余重秀北京邮电大学电子工程学院北京100876 北京交通大学理学院北京100044

以完美匹配层为边界条件,用复有限元法分析了椭圆空气孔三角形微结构光纤中基模的限制损耗.数值结果表明:当孔间距,空气填充率和空气孔环数增大时,基模的限制损耗减小.从计算结果还可以得出:限制损耗与基模的偏振有关,随着孔间距,空气... 详细信息

以完美匹配层为边界条件,用复有限元法分析了椭圆空气孔三角形微结构光纤中基模的限制损耗.数值结果表明:当孔间距,空气填充率和空气孔环数增大时,基模的限制损耗减小.从计算结果还可以得出:限制损耗与基模的偏振有关,随着孔间距,空气填充率和孔的椭圆率的增大,y偏振模与x偏振模的限制损耗比也增大.最后,提出了两种可实现光单偏振,单模传输的高非线性微结构光纤.

关键词：微结构光纤限制损耗复有限元法完美匹配层

Regulation of estrogen receptors α and β in human breast carcinoma by exogenous leptin in nude mouse xenograft model

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Chinese Medical Journal 2010年第3期000卷 337-343页

作者： yu Wei GU Jun-chao LIU jian-zhong WANG Shao-hong WANG yu ZHANG Zhong-tao MA Xue-mei SONG Mao-min Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of General Surgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background It is essential to clarify the interactions of hormones during the progression of human breast cancer. This study examined the effects of exogenous human leptin on estrogen receptor （ER） α and β in human breast tumor tissue in a nude mouse xenograft model. Methods We created nude mice xenografts of MCF-7 human breast cancer cells, and randomly divided them into an experimental group and a control group. The mice in experimental group were injected subcutaneously around tumors with human leptin, while the control group were injected with the same dose of normal saline. A real-time RT-PCR assay was developed to quantify the mRNA of ERα, β in the tumor tissues. Western blotting analyses were used to assess the relative quantities of the ERα , β proteins. Results Leptin-treated xenografted nude mice were successfully established. The amount of ERa mRNA was significantly higher in the leptin group than in the control group （P 〈0.01）, while the amount of ERβ mRNA was significantly lower in the leptin group than in the control group （P 〈0.01）. Western blotting analyses revealed that the ERa protein level was significantly higher in the leptin group than in the control group （P 〈0.01）, while the ERβ protein level was significantly lower in the leptin group than in the control group （P 〈0.01）. Conclusions Nude mouse xenograft model can be safely and serviceably treated with human leptin by subcutaneous injections around tumor. ERα, β were both targets of leptin in breast cancer. Leptin can up-regulate the expression of ERa and down-regulate the expression of the ERβ in human breast tumor.

关键词： human leptin xenografl model estrogen receptors α and β

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huang jian-yun Peng Hai-Yi Long Xian Zhong yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

混沌神经网络逆控制的同步及其在保密通信系统中的应用

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物理学报 2005年第9期54卷 4012-4018页

作者：于灵慧房建成北京航空航天大学第五研究室北京100083

利用神经网络的学习、逼近能力构造混沌神经网络,提出逆控制混沌同步方法来同步两个混沌神经网络,并基于逆控制和混沌神经网络的同步给出一种新的混沌保密通信系统.理论分析和数值实验结果表明,新系统能够有效地克服信道噪声对信息传输... 详细信息

利用神经网络的学习、逼近能力构造混沌神经网络,提出逆控制混沌同步方法来同步两个混沌神经网络,并基于逆控制和混沌神经网络的同步给出一种新的混沌保密通信系统.理论分析和数值实验结果表明,新系统能够有效地克服信道噪声对信息传输的不良影响,具有较强通用性和柔韧性,且有同步速度快,信号恢复精度高和密钥量大的优点.

关键词：混沌同步自适应逆控制混沌神经网络保密通信保密通信系统同步方法逆控制应用逼近能力控制混沌数值实验不良影响