Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered
作者机构:Department of Medical UltrasonicsThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina
出 版 物:《World Journal of Hepatology》 (世界肝病学杂志(英文版)(电子版))
年 卷 期:2024年第16卷第7期
页 面:1018-1028页
学科分类:1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学]
基 金:Supported by Natural Science Foundation of Guangdong Province,No.2023A1515012464 and No.2022A1515011716 Basic and Applied Basic Research Foundation of Guangdong Province,No.2022A1515110666
主 题:Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma
摘 要:BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.