In vitro corrosion behavior and cytotoxicity property of magnesium matrix composite with chitosan coating

作     者：戴翌龙 余琨 陈良建 陈畅 乔雪岩 颜阳 DAI Yi-long;YU Kun;CHEN Liang-jian;CHEN Chang;QIAO Xue-yan;YAN Yang

作者机构：School of Materials Science and Engineering Central South University State Key Laboratory of Powder Metallurgy (Central South University) Xiang Ya Third Hospital Central South University 

出 版 物：《Journal of Central South University》 (中南大学学报（英文版）)

年 卷 期：2015年第22卷第3期

页      面：829-834页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Project(2012zzts068) supported by the Fundamental Research Funds for the Central Universities of Central South University,China Project(2010fj3091) supported by the Open Funding of State Key Laboratory of Powder Metallurgy and Science&Technology Foundation,China 

主　　题：magnesium matrix composite chitosan coating in vitro test cytotoxicity 

摘      要：Mg-6%Zn-10%β-Ca3(PO4)2 composite was prepared through powder metallurgy methods with different chitosan coatings on its surface. The properties of the chitosan coatings on the surface of Mg-6%Zn-10%β-Ca3(PO4)2 composite, such as the adhesion ability, the corrosion behavior and the cytotoxicity properties, were investigated, and the microstructure of the chitosan coating was observed by scanning electron microscope(SEM). The results show that chitosan coating improves the corrosion resistance of the magnesium composite specimens significantly. Mg-6%Zn-10%β-Ca3(PO4)2 composite specimens exhibit good corrosion resistance and low p H values in simulated body fluid(SBF) at 37 °C in the immersion test with 7-layer chitosan coating whose relative molecular mass is 30×104 Da. The cytotoxicity tests indicate that Mg-6%Zn-10%β-Ca3(PO4)2 with chitosan coating is nontoxic with a cytotoxicity grade of zero against L-929 cells, which is better than that of uncoated composites.