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COVId-19 and earlier pandemics,sepsis,and vaccines:A historical perspective

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Journal of Intensive Medicine 2021年第1期1卷 4-13页

作者： jean-marc Cavaillon marcin f.Osuchowski french National Research Agency(ANR) Paris 75012France Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center Vienna 1200Austria

Humanity has regularly faced the threat of epidemics and pandemics over the course of *** at-tempts to protect populations were initially made with the development of new vaccines,such as those against plague and cholera,under the leadership of the bacteriologist Waldemar *** have led to a complete eradication of smallpox and bovine plague and a major reduction in other infectious diseases including diphthe-ria,typhoid fever,poliomyelitis,and Haemophilus influenzae type B *** a few coronaviruses have been identified that seasonally infect humans causing mild symptoms,the emergence of a new zoonotic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has rapidly triggered the ongoing coronavirus disease 2019(COVId-19)as a global pandemic responsible for widespread *** severe phenotypes of COVId-19 resemble a previous infectious threat that was initially designated as hospital fever and puerperal fever,presently known as sepsis.A SARS-CoV-2 infection has frequently been considered as a form of viral sepsis(owing to com-mon features with bacterial sepsis)but is also associated with an array of specific and unique *** progress in anti-SARS-CoV-2 vaccine development,in particular,the design of efficient messenger RNA(mRNA)and recombinant adenovirus vaccines,is crucial for curbing the pandemic.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus Sepsis Cytokines Hydroxychloroquine Vaccines Pandemics

In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethaneurea)scaffold as an easy handling elastomeric biomaterial for bone regeneration

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Regenerative Biomaterials 2019年第6期6卷 311-323页

作者： Geraldine Rohman Sylvie Changotade Sophie frasca Salah Ramtani Anne Consalus Credson Langueh jean-marc Collombet didier Lutomski Universite Paris 13 Sorbonne Paris CiteTissue Engineering and Proteomics(TIP)TeamCSPBATUMR CNRS 724474 rue Marcel Cachin93000 BobignyFrance departement Soutien Medico-Chirurgical des forces(SMCf) BP73Institut de Recherche Biomedicale des Armees(IRBA)91223 Bretigny-sur-Orge CedexFrance UniversiteParis 13 Sorbonne Paris CiteLBPS TeamCSPBATUMR CNRS 724499 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance

Bone loss can occur as a result of various pathologies,traumas and injuries and poor bone healing leads to functionally debilitating condition,loss of self-sufficiency and deterioration in life *** the increasing incidence of facial trauma and the emergence of new procedural techniques,advanced scaffolds are currently developed as substitutes for bone tissue *** this study,we investigated the capability of a chemically cross-linked e-caprolactone-based poly(esterurethane-urea)(PCLU)scaffold to support bone *** vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold ***,PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3d spatial arrangement,and allowed osteogenic differentiation under appropriate *** vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in *** histology and microtomography analysis,we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed ***,no sign of inflammation or rejection was *** envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.

关键词： bone regeneration scaffold elastomer PEUU PCLU

Zn38Mg12Ca32Yb18大块金属玻璃的晶化动力学行为（英文）

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稀有金属材料与工程 2019年第5期48卷 1429-1434页

作者：乔吉超 Pelletier jean-marc 姚尧葛渊西北工业大学陕西西安710072 Universite de Lyon MATEISUMR CNRS5510Bat.B.PascalINSA-LyonF-69621 Villeurbanne CedexFrance 西北有色金属研究院金属多孔材料国家重点实验室陕西西安710016

采用差示扫描量热分析仪,研究了Zn38Mg12Ca32Yb18大块金属玻璃的在等时和等温状态下的晶化动力学行为。在等时条件下,不同的理论模型来分析特征温度的名义激活能。结果表明,采用Kissinger模型,flynn-Wall-Ozawa模型和Augis-Bennett模型... 详细信息

采用差示扫描量热分析仪,研究了Zn38Mg12Ca32Yb18大块金属玻璃的在等时和等温状态下的晶化动力学行为。在等时条件下,不同的理论模型来分析特征温度的名义激活能。结果表明,采用Kissinger模型,flynn-Wall-Ozawa模型和Augis-Bennett模型计算的名义激活能相互吻合。再者,采用Johnson-Mehl-Avrami模型分析了等温过程中晶化转变动力学机。Avrami指数n的分布区间介于3.25到4.12。分析发现,在等温晶化过程中采用Arrhenius方程计算得到的激活能比在等时晶化过中采用Kissinger方程的激活能要大,这可能是由于等温退火过程中能垒比等时晶化过程中的要高所引起的。

关键词：金属玻璃差示扫描量热分析仪晶化动力学 Johnson-Mehl-Avrami模型 Avrami指数

Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes

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Asian Journal of Andrology 2019年第5期21卷 445-451页

作者： Anne-Laure Barbotin Anais dauvergne Agathe dumont Nassima Ramdane Valerie Mitchell jean-marc Rigot florence Boitrelle Geoffroy Robin CHU lille Reproductive Biology-Spermiology-CECOS InstituteJeanne de Fla nd re HospitalF-59000 LilleFrance EA4308:Gametogenesis and Gamete Quality Lille UniversityF-59000 LilleFrance CHU lille Department of AndrologyCalmette HospitalF-59000 LilleFrance CHU lille Department of Endocrine Gynaecology and Reproductive MedicineJeanne de Flandre HospitalF-59000 LilleFrance CHU lille Department of BiostatisticsEA2694Lille UniversityF-59000 LilleFrance fertility Unit Poissy-Saint-Germain-en-Laye General Hospital78303 PoissyFrance.

Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in *** it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous ***,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral *** results show no difference in follicle-stimulating hormone(fSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay's detection limit)was positively associated with successful sperm retrieval(Pding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and.live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(fSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral *** suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular ***,inhibin B level might be a predictor of successful TESE.

关键词： cryptorchidism in tracytoplasmic sperm in jection non obstructive azoospermia testicular sperm extraction

On the Role of Chloroplasts in the Polymerization of Tannins in Tracheophyta: A Monograph

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American Journal of Plant Sciences 2015年第9期6卷 1401-1409页

作者： jean-marc Brillouet UMR SPO INRA/SupAgro/UM I Montpellier France

Proanthocyanidins are formed in the chlorophyllous organs of Tracheophyta from a redifferentiation of chloroplasts involving the thylakoidal membrane and lumen. With the purpose to help researchers of concerned disciplines to identify such chloroplasts, we described herein the morphologies of functional and redifferentiating chloroplasts in various members of Tracheophyta. The most obvious sign of redifferentiation is a tremendous swelling of the chloroplast which turns obese. de novo genesis of osmiophilic materials is also characteristic, either as single dots attached to the inner face of the swollen thylakoidal membrane which will yield the tannosomes, or as pearl necklace-shaped structures protruding into the lumen;this last formation can be viewed as a giant tannosome forming finally stromal chlorotannic accretions. Whatever their mode of formation is, tannosomes are expulsed from the chloroplast as shuttles.

关键词： Condensed Tannins Proanthocyanidins Thylakoids Tannosome Plastid Tracheophyta

Reflected BSdEs driven by Lévy Processes and Countable Brownian Motions

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Applied Mathematics 2015年第14期6卷 2240-2247页

作者： jean-marc Owo UfR de Mathé matiques et Informatique Universit&eacute fé lix H. Boigny Abidjan C&ocirc te d’Ivoire

A new class of reflected backward stochastic differential equations (RBSdEs) driven by Teugels martingales associated with Lévy process and Countable Brownian Motions are investigated. Via approximation, the existenc... 详细信息

关键词： Backward doubly Stochastic differential Equations Lévy Processes Teugels Martingales Countable Brownian Motions

The Grammars of Mystical Experience in Christian Theological dialogue

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Journal of Philosophy Study 2018年第4期8卷 151-168页

作者： marc jean-Bernard University of Puerto Rico

The philosophical horizon of this essay is theoretically comparative and hermeneutically dialogic. Its main philosophical and theological tonality expresses, in first person and through three discursive moments, the differentiated fusion of horizons between phenomenological and grammatical description and understanding of experience. After a philosophical overture-outlining the ethos of the dialogic problematic and situating it within the contemporary diverse and dialogic dynamic of phenomenology-I will expose the consistent, possible mod.lities of convergence between Husserlian phenomenology and Wittgensteinian grammar of the mystical shapes of experience. The tense, responsorial dialogue among Husserl, Heidegger, Levinas, and Wittgenstein＇s styles of thinking, far from being anymore limited to the debates between the analytical and phenomenological, will be considered from the crossed categorial spaces of Austrian philosophy and German culture in general. In a second section, I will show how the styles of phenomenology today are advancing into a cautious micro-logical grammar of comparative inquiry. This thematization will first consider some precise semantic clarifications： Experience, the mystical, extasis, evidence, and truth; in a second section, the theoretical levels of grammar and phenomenology of mystical experience are heralded in the context of the Christian theological dialogue, where I emphasize the rebirth of french theological thinking and dialogic transcendence, beginning with Maritain and de Chardin to marcel, de Lubac, Levinas, and Marion. finally, I consider the aesthetic expressions of mystical experience, both from the visual and musical dimensions. I will conclude this talk by highlighting theological perspectives drawn from my research in musico-philosophical problematics, through an awakening to the resonance of Being and the divine in sonic and musical life. Through a theology of the musical λογοζ, the grammar of mystical experience reveals

关键词： phenomenology grammar mysticism theology ontology dialogue music silence

Carbonized nano/microparticles for enhanced mechanical properties and electromagnetic interference shielding of cementitious materials

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frontiers of Structural and Civil Engineering 2016年第2期10卷 209-213页

作者： Rao Arsalan KHUSHNOOd Sajjad AHMAd Luciana RESTUCCIA Consuelo SPOTO Pravin JAGdALE jean-marc TULliANI Giuseppe Andrea fERRO department of StructuraL Geotechnical and Building Engineering(dISEG) Politecnico di Torino10129 TorinoItaly Nust Institute of Civil Engineering(NICE) National University of Sciences and Technology(NUST)44000 IslamabadPakistan Mirpur University of Science and Technology(MUST) 10250 MirpurAzad KashmirPakistan department of Applied Science and Technology(dISAT) Politecnico di Torino10129 TorinoItaly

In the present work, carbon nano/microparticles obtained by controlled pyrolysis of peanut （PS） and hazelnut （HS） shells are presented. These materials were characterized by Raman spectroscopy and field emissionscanning electron microscopy （fE-SEM）. When added to cement paste, up to 1 wt%, these materials led to an increase of the cement matrix flexural strength and of toughness. Moreover, with respect to plain cement, the total increase in electromagnetic radiation shielding effect when adding 0.5 wt% of PS or HS in cement composites is much higher in comparison to the ones reported in the literature for CNTs used in the same content.

关键词： carbon nano/microparticles green cement toughness mechanism electromagnetic shielding effect

Barcelona clinic liver cancer nomogram and others staging/scoring systems in a french hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda jean Luc Raoul Julien Ed.line jean-frédéric Blanc Bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut jean Pierre Bronowicki marc Bourlière department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille department of Hepato-Gastroenterology and digestive Oncology Institut Paoli-Calmette Marseille department of Hepato-Gastroenterology and digestive Oncology Centre Eugène Marquis Rennes department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille department of Radiology Hopital Saint-Joseph Marseille department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CliP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) french *** data were collected retrospectively from 01/2007 to 12/2013 in five french centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and d(7%). first line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P d the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this french cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CliP Hepatocellular carcinoma