Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes

作     者：Anne-Laure Barbotin Anais Dauvergne Agathe Dumont Nassima Ramdane Valerie Mitchell Jean-Marc Rigot Florence Boitrelle Geoffroy Robin 

作者机构：CHU LilleReproductive Biology-Spermiology-CECOS InstituteJeanne de Fla nd re HospitalF-59000 LilleFrance EA4308:Gametogenesis and Gamete QualityLille UniversityF-59000 LilleFrance CHU LilleDepartment of AndrologyCalmette HospitalF-59000 LilleFrance CHU LilleDepartment of Endocrine Gynaecology and Reproductive MedicineJeanne de Flandre HospitalF-59000 LilleFrance CHU LilleDepartment of BiostatisticsEA2694Lille UniversityF-59000 LilleFrance Fertility UnitPoissy-Saint-Germain-en-Laye General Hospital78303 PoissyFrance. 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2019年第21卷第5期

页      面：445-451页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：We gratefully acknowledge the support and assistance provided by all the staff of Lille University Hospital's in vitro fertilization unit 

主　　题：cryptorchidism in tracytoplasmic sperm in jection non obstructive azoospermia testicular sperm extraction 

摘      要：Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in *** it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous ***,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral *** results show no difference in follicle-stimulating hormone(FSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay s detection limit)was positively associated with successful sperm retrieval(P0.05).Regarding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(FSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral *** suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular ***,inhibin B level might be a predictor of successful TESE.