In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethaneurea)scaffold as an easy handling elastomeric biomaterial for bone regeneration

作     者：Geraldine Rohman Sylvie Changotade Sophie Frasca Salah Ramtani Anne Consalus Credson Langueh Jean-Marc Collombet Didier Lutomski 

作者机构：Universite Paris 13Sorbonne Paris CiteTissue Engineering and Proteomics(TIP)TeamCSPBATUMR CNRS 724474 rue Marcel Cachin93000 BobignyFrance Departement Soutien Medico-Chirurgical des Forces(SMCF)BP73Institut de Recherche Biomedicale des Armees(IRBA)91223 Bretigny-sur-Orge CedexFrance UniversiteParis 13Sorbonne Paris CiteLBPS TeamCSPBATUMR CNRS 724499 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2019年第6卷第6期

页      面：311-323页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the French Fondation des Gueules Cassees,the Delegation Generale pour l’Armement(DGA)of the French Ministry of Defense the Interdisciplinary Institute of Experimental Sciences of the Universite Paris 13 

主　　题：bone regeneration scaffold elastomer PEUU PCLU 

摘      要：Bone loss can occur as a result of various pathologies,traumas and injuries and poor bone healing leads to functionally debilitating condition,loss of self-sufficiency and deterioration in life *** the increasing incidence of facial trauma and the emergence of new procedural techniques,advanced scaffolds are currently developed as substitutes for bone tissue *** this study,we investigated the capability of a chemically cross-linked e-caprolactone-based poly(esterurethane-urea)(PCLU)scaffold to support bone *** vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold ***,PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement,and allowed osteogenic differentiation under appropriate *** vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in *** histology and microtomography analysis,we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed ***,no sign of inflammation or rejection was *** envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.