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Journal of Partial Differential Equations 2023年第4期36卷 381-393页

作者： AHMAD Manzoor MISHRA Rajshree jain renu School of Mathematics and Allied Sciences jiwaji UniversityGwalior-474011India Govt.Model Science College Gwalior-474011India

.Option pricing is a major problem in quantitative *** Black-Scholes model proves to be an effective model for the pricing of *** this paper a com-putational method known as the modified differential transform method has been em-ployed to obtain the series solution of Black-Scholes equation with boundary condi-tions for European call and put options paying continuous *** proposed method does not need discretization to find out the solution and thus the computa-tional work is reduced *** results are plotted graphically to establish the accuracy and efficacy of the proposed method.

关键词： European option pricing Black-Scholes equation call option put option modified differential transform method

(p,q)-Analogue of Mittag-Leffler Function with(p,q)-Laplace Transform

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Analysis in Theory and Applications 2022年第3期38卷 351-360页

作者： Alok jain Altaf Ahmad Bhat renu jain Deepak Kumar jain School of Mathematics and Allied Sciences Jiwaji UniversityGwalior(M.P.)India Department of Mathematical Sciences Islamic University of Science and TechnologyAwantipora PulwamaJand KIndia-192122 Department of Engineering Mathematics and Computing MITSGwalior(M.P.)India

The aim of this paper is to define(p,q)-analogue of Mittag-Leffler Function,by using(p,q)-Gamma *** transformation formulae are also derived by using the(p,q)-***(p,q)-analogue for this function provides elegant generalization of q-analogue of Mittag-Leffler function in connection with ***,the(p,q)-Laplace Transform of the Mittag-Leffler function has been *** special cases have also been discussed.

关键词： (p,q)-analogue of Mittag-Leffler function (p,q)-Gamma function q-calculus (p,q)-derivative operator (p,q)-Laplace transform

New solutions for old challenges in glaucoma treatment:is taurine an option to consider?

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Neural Regeneration Research 2021年第5期16卷 967-971页

作者： Igor Iezhitsa renu Agarwal School of Medicine International Medical UniversityKuala LumpurMalaysia Volgograd State Medical University Research Centre for Innovative MedicinesVolgogradRussian Federation

Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field *** is recognized as a leading cause of irreversible blindness affecting more than 70 million people ***,reduction of intraocular pressure,a widely recognized risk factor for glaucoma development,is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease ***,retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma,suggesting that the disease process is partially independent of intraocular *** is one of the agents that have attracted attention of researchers *** has been shown to be involved in multiple cellular functions,including a central role as a neurotransmitter,as a trophic factor in the central nervous system development,as an osmolyte,as a neuromodulator,and as a *** also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and *** is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells.A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in *** effect of taurine may be attributed to direct inhibition of apoptosis,an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative *** studies are needed to fully explore the potential of taurine as a neuroprotective agent,so that it can be applied in clinical practice,particularly for the treatment of *** objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.

关键词： apoptosis excitotoxicity glaucoma oxidative and nitrosative stresses retinal neuroprotection taurine

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Magnesium acethyltaurate as a potential agent for retinal and optic nerve protection in glaucoma

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Neural Regeneration Research 2018年第5期13卷 807-808页

作者： Igor Iezhitsa renu Agarwal Centre for Neuroscience Research Faculty of Medicine Universiti Teknologi MARA Volgograd State Medical University Research Institute of Pharmacology

Glaucoma is the second leading cause of irreversible vision impairment affecting more than 70 million people worldwide with approximately 10%suffering from glaucoma-related bilateral blind（Quigley and Broman,2006）.It is a multi-factorial disease that is characterized by optic nerve damage and visual field *** loss of retinal ganglion cells（RGCs）resulting in visual field deficits is the hallmark of glaucoma.

关键词： Magnesium acethyltaurate as a potential agent for retinal and optic nerve protection in glaucoma

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Contribution of epigenetics in diabetic retinopathy

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Science China(Life Sciences) 2015年第6期58卷 556-563页

作者： KOWLURU renu A. MISHRA Manish Kresge Eye Institute Wayne State University

Diabetes has become the epidemic of the 21 st century, and with over 90% patients with diabetes becoming at a risk of developing retinopathy, diabetic retinopathy has emerged as a major public health concern. In spite of cutting edge research in the field, how retina and its vasculature are damaged by the diabetic milieu remains ambiguous. The environmental factors, life style or disease process can also bring in modifications in the DNA, and these epigenetic modifications either silence or activate a gene without altering the DNA sequence. Diabetic environment up- or downregulates a number of genes in the retina, and emerging research has shown that it also facilitates epigenetic modifications. In the pathogenesis of diabetic retinopathy, the genes associated with important enzymes(e.g., mitochondrial superoxide dismutase, matrix metalloproteinase-9 and thioredoxin interacting protein) and transcriptional factors are epigenetically modified, the enzymes responsible for these epigenetic modifications are either activated or inhibited, and the levels of micro RNAs are altered. With epigenetic modifications taking an important place in diabetic retinopathy, it is now becoming critical to evaluate these modifications, and understand their impact on this slow progressing blinding disease.

关键词： diabetic retinopathy epigenetic modifications histone acetylation histone methylation miRNA

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Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes

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World Journal of Clinical Pediatrics 2025年第1期14卷 6-20页

作者： Amreen Shamsad Tanu Gautam renu Singh Monisha Banerjee Molecular and Human Genetics Laboratory Department of ZoologyUniversity of LucknowLucknow 226007Uttar PradeshIndia Department of Obstetrics and Gynecology King George’s Medical UniversityLucknow 226003Uttar PradeshIndia

Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of *** is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,and neurological *** investigations have focused on the correlation of genetic factors such asβ-cell function and insulin secretary genes(transcription factor 7 like 2,potassium voltage-gated channel subfamily q member 1,adipo-nectin etc.)on maternal metabolism during gestation leading to *** alterations like DNA methylation,histone modification,and miRNA expression can influence gene expression and play a dominant role in feto-maternal meta-bolic *** between genes and environment,resulting in differ-ential gene expression patterns may lead to *** suggested that GDM women are more susceptible to insulin resistance,which alters intrauterine surroundings,resulting hyperglycemia and *** modi-fications in genes affecting neuroendocrine activities,and metabolism,increase the risk of obesity and type 2 diabetes in *** is currently no treatment or effective preventive method for GDM,since the molecular processes of insulin resistance are not well *** present review was undertaken to un-derstand the pathophysiology of GDM and its effects on adverse neonatal *** addition,the study of genetic and epigenetic alterations will provide lead to researchers in the search for predictive molecular biomarkers.

关键词： Gene expression Gestational diabetes mellitus Feto-maternal outcome Epigenetic alteration Molecular biomarkers

Effect of nitrogen doping on structural and optical properties of ZnO nanoparticles

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Progress in Natural Science:Materials International 2015年第4期25卷 300-309页

作者： renu Kumari Anshuman Sahai Navendu Goswami Inter University Accelerator Centre Aruna Asaf Ali Marg Department of Physics and Materials Science and Engineering Jaypee Institute of Information Technology

Infl uence of nitrogen doping on structural and optical properties of ZnO nanoparticles has been studied. Undoped and N doped ZnO nanoparticles were synthesized via chemical precipitation approach. The prepared samples were characterized through X-ray diffraction(XRD),Transmission electron microscopy(TEM) equipped with Energy dispersive X-ray(EDAX) spectroscopy, UV–visible spectroscopy, Fourier transform infrared(FTIR) spectroscopy and micro-Raman spectroscopy(m RS). Wurtzite phase of undoped as well as 0.5–10% N doped ZnO nanoparticles was con fi rmed through characteristic XRD patterns. The particle size expansion due to N incorporation in ZnO was further revealed by TEM and EDAX analysis where 11 nm size undoped and 18–22 nm size 0.5–10% N doped ZnO(N:ZnO) nanoparticles without any impurity were ascertained. Slight blue-shift in band gap energy, as observed in our case, symbolized weak quantum con fi nement of the prepared nanoparticles. The alterations in vibrational modes of ZnO due to N incorporation, remarkably H substituting at O site and subsequently causing the passivation in N:ZnO nanoparticles, were detected through FTIR analysis. Finally, the effect of the nano-size of crystallite and gradual prominence of N into ZnO lattice due to increase of N doping concentration in prepared nanoparticles was meticulously expatiated though m RS analysis.

关键词： II–VI Semiconductors Infrared spectra Raman spectra Optical properties of low-dimensional Mesoscopic Nanoscale materials and structures

Faulty homocysteine recycling in diabetic retinopathy

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Eye and Vision 2020年第1期7卷 36-46页

作者： renu A.Kowluru Ghulam Mohammad Nikhil Sahajpal Department of Ophthalmology Visual Sciences and Anatomical SciencesWayne State University4717 St.AntoineDetroitMI 48201USA

Background:Although hyperglycemia is the main instigator in the development of diabetic retinopathy,elevated circulating levels of a non-protein amino acid,homocysteine,are also associated with an increased risk of *** is recycled back to methionine by methylenetetrahydrofolate reductase(MTHFR)and/or transsulfurated by cystathionineβ-synthase(CBS)to form *** and other transsulfuration enzyme cystathionine-γ-lyase(CSE),through desulfuration,generates H_(2)*** cycle also regulates DNA methylation,an epigenetic modification associated with the gene *** aim of this study was to investigate homocysteine and its metabolism in diabetic ***:Homocysteine and H_(2)S levels were analyzed in the retina,and CBS,CSE and MTHFR in the retinal microvasculature from human donors with established diabetic *** damage was evaluated in retinal microvessels by quantifying enzymes responsible for maintaining mitochondrial dynamics(fission-fusionmitophagy).DNA methylation status of CBS and MTHFR promoters was examined using methylated DNA immunoprecipitation *** direct effect of homocysteine on mitochondrial damage was confirmed in human retinal endothelial cells(HRECs)incubated with 100μM ***:Compared to age-matched nondiabetic control human donors,retina from donors with established diabetic retinopathy had~3-fold higher homocysteine levels and~50%lower H_(2)S *** enzymes important for both transsulfuration and remethylation of homocysteine including CBS,CSE and MTHFR,were 40–60%lower in the retinal microvasculature from diabetic retinopathy *** the mitochondrial fission protein,dynamin related protein 1,and mitophagy markers optineurin and microtubule-associated protein 1A/1B-light chain 3(LC3),were upregulated,the fusion protein mitofusin 2 was *** the same retinal microvessel preparations from donors with diabetic retinopathy,DNA at the prom

关键词： Diabetic retinopathy DNA methylation Homocysteine Hydrogen sulfide Mitophagy Epigenetics Mitochondria Oxidative stress Retina

AHP-neutrosophic decision model for selection of relay node in wireless body area network

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 222-229页

作者： Naveen Bilandi Harsh KVerma renu Dhir Department of Computer Science and Engineering National Institute of TechnologyJalandharPunjabIndia Department of Computer Science and Engineering DAV UniversityJalandharPunjabIndia

The medical health systems empowered by wireless body area networks(WBANs)are becoming a reliable technology with unmatched facilities for personalised health monitoring and managing real-time health issues.A WBAN is primarily composed of a miniature,and smart devices called sensors that are worn in,on,or around the human *** recent years,research has been mainly centred towards the reduction of the energy consumption and stability of the *** selection of the relay node is one of the foremost issues for balancing the energy consumption in *** overcome this issue,the authors propose a hybrid analytic hierarchy process-neutrosophic method for making the decision of the relay node selection,in which the analytic hierarchy process(AHP)technique calculates the weights for different criteria and forwards them to the neutrosophic technique which finds out the best alternative solution or choice which is closest to the ideal solution.A detailed analysis is carried out on multi-criteria decision-making techniques by comparing the proposed AHP-neutrosophic and AHP techniques taking into account various criteria and *** experimental outcomes of this research indicate a significant reduction in terms of energy consumption and enhanced overall network-stability.

关键词： network overcome weights

Pathogenesis of achalasia cardia

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World Journal of Gastroenterology 2012年第24期18卷 3050-3057页

作者： Uday C Ghoshal Sunil B Daschakraborty renu Singh Department of Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226104India

Achalasia cardia is one of the common causes of motor *** the disease was first described more than 300 years ago,exact pathogenesis of this condition still remains ***,achalasia cardia is caused by loss of inhibitory ganglion in the myenteric plexus of the *** the initial stage,degeneration of inhibitory nerves in the esophagus results in unopposed action of excitatory neurotransmitters such as acetylcholine,resulting in high amplitude non-peristaltic contractions(vigorous achalasia);progressive loss of cholinergic neurons over time results in dilation and low amplitude simultaneous contractions in the esophageal body(classic achalasia).Since the initial description,several studies have attempted to explore initiating agents that may cause the disease,such as viral infection,other environmental factors,autoimmunity,and genetic *** Chagas disease,which mimics achalasia,is caused by an infective agent,available evidence suggests that infection may not be an independent cause of primary achalasia.A genetic basis for achalasia is supported by reports showing occurrence of disease in monozygotic twins,siblings and other first-degree relatives and occurrence in association with other genetic diseases such as Down's syndrome and Parkinson's *** in genes encoding for nitric oxide synthase,receptors for vasoactive intestinal peptide,interleukin 23 and the ALADIN gene have been ***,studies on larger numbers of patients and controls from different ethnic groups are needed before definite conclusions can be ***,the disease is believed to be multi-factorial,with autoimmune mechanisms triggered by infection in a genetically predisposed individual leading to degeneration of inhibitory ganglia in the wall of the esophagus.

关键词： Esophagus Motor dysphagia Motility disor-der Peristalsis Esophageal sphincter