Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes

作     者：Amreen Shamsad Tanu Gautam Renu Singh Monisha Banerjee 

作者机构：Molecular and Human Genetics LaboratoryDepartment of ZoologyUniversity of LucknowLucknow 226007Uttar PradeshIndia Department of Obstetrics and GynecologyKing George’s Medical UniversityLucknow 226003Uttar PradeshIndia 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志（英文）)

年 卷 期：2025年第14卷第1期

页      面：6-20页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：Supported by Maulana Azad National Fellowship,University Grants Commission,New Delhi,and Department of Biotechnology,New Delhi,No.AS[82-27/2019(SA III)] DBT-BUILDER-University of Lucknow Interdisciplinary Life Science Programme for Advance Research and Education(Level II),No.TG(BT/INF/22/SP47623/2022) 

主　　题：Gene expression Gestational diabetes mellitus Feto-maternal outcome Epigenetic alteration Molecular biomarkers 

摘      要：Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of *** is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,and neurological *** investigations have focused on the correlation of genetic factors such asβ-cell function and insulin secretary genes(transcription factor 7 like 2,potassium voltage-gated channel subfamily q member 1,adipo-nectin etc.)on maternal metabolism during gestation leading to *** alterations like DNA methylation,histone modification,and miRNA expression can influence gene expression and play a dominant role in feto-maternal meta-bolic *** between genes and environment,resulting in differ-ential gene expression patterns may lead to *** suggested that GDM women are more susceptible to insulin resistance,which alters intrauterine surroundings,resulting hyperglycemia and *** modi-fications in genes affecting neuroendocrine activities,and metabolism,increase the risk of obesity and type 2 diabetes in *** is currently no treatment or effective preventive method for GDM,since the molecular processes of insulin resistance are not well *** present review was undertaken to un-derstand the pathophysiology of GDM and its effects on adverse neonatal *** addition,the study of genetic and epigenetic alterations will provide lead to researchers in the search for predictive molecular biomarkers.