New solutions for old challenges in glaucoma treatment:is taurine an option to consider?

作     者：Igor Iezhitsa Renu Agarwal Igor Iezhitsa;Renu Agarwal

作者机构：School of MedicineInternational Medical UniversityKuala LumpurMalaysia Volgograd State Medical UniversityResearch Centre for Innovative MedicinesVolgogradRussian Federation 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第5期

页      面：967-971页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：This work was financially supported by the Institut Pengurusan Penyelidikan(RMI) Universiti Teknologi MARA Malaysia under grants 600-IRMI/MyRA 5/3/BESTARI(004/2017)and 600-IRMI/MyRA 5/3/BESTARI(006/2017) 

主　　题：apoptosis excitotoxicity glaucoma oxidative and nitrosative stresses retinal neuroprotection taurine 

摘      要：Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field *** is recognized as a leading cause of irreversible blindness affecting more than 70 million people ***,reduction of intraocular pressure,a widely recognized risk factor for glaucoma development,is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease ***,retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma,suggesting that the disease process is partially independent of intraocular *** is one of the agents that have attracted attention of researchers *** has been shown to be involved in multiple cellular functions,including a central role as a neurotransmitter,as a trophic factor in the central nervous system development,as an osmolyte,as a neuromodulator,and as a *** also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and *** is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells.A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in *** effect of taurine may be attributed to direct inhibition of apoptosis,an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative *** studies are needed to fully explore the potential of taurine as a neuroprotective agent,so that it can be applied in clinical practice,particularly for the treatment of *** objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.