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Effects of <i>Pereskia aculeata</i>Miller on the Biochemical Profiles and Body Composition of Wistar Rats

journal of Biosciences and Medicines 2015年第7期3卷 82-89页

作者： Maricelma da Silva Soares de souza Sandra Maria Barbalho Elen Landgraf Guiguer Adriano Cressoni Araújo Patrícia Cincotto dos Santos bueno Flávia Maria Vasquez Farinazzi-Machado Larissa Maria de Lara Lima Beatriz Clivati da Silva Claudemir Gregório Mendes department of Biochemistry and Pharmacology School of Medicine University of Marília Marília Brazil department of Biochemistry and Nutrition Faculty of Food Technology of Marília (FATEC) Marília Brazil

Pereskia aculeata Miller commonly known as “ora-pro-nobis” has been used extensively in folclore medicine. Plant belongs to the family Cactacea and it is found in the Brazil (reaching Bahia and Rio Grande do Sul states). The purpose was to evaluate the effects of plant on biochemical and corporal profiles of Wistar rats. The 80 animals were divided randomly into 4 groups by sex (n = 10 females and 10 males per group) as follows: G1 group (water/rat food ad libitum);G2 group (drink A: commercial condensed milk, sugar and water/rat food ad libitum);G3 group (drink B: P. aculeata juice/rat food ad libitum);G4 group (drink C: commercial condensed milk, sugar and P. aculeate juice/rat food ad libitum). After 35 days their biochemical and corporal profiles were analyzed (cholesterol, glycemia, triglycerides, HDL-c, AST, ALT, Lee Index, weight and visceral fat). Intake of the plant caused no changes in the lipid profile of Wistar rats. However, intake in male rats of the same prevented the increase in triglycerides front of a hypercaloric diet. There were significant changes in glycemic index due to the high carbohydrate content of the plant. The plant was effective in reducing the levels of AST and ALT in male rats and ALT only in females. The use of the plant did not cause significant changes in the index of Lee but the Pereskia aculeata Miller may reduce visceral fat gain in female with a regular diet.

关键词： Pereskia aculeata Wistar Rats Glycemia Lipids Visceral Fat

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Quantitative analysis of trigonelline in some Annona species by proton NMR spectroscopy

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Natural Products and Bioprospecting 2013年第4期3卷 158-160页

作者： Alan Rodrigues Teixeira MACHADO Gisele Avelar LAGE Felipe da Silva MEdeIROS josé Dias de souza filho Lúcia Pinheiro Santos PIMENTA departamento de Química ICExUniversidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil

A quantitative ^(1)H NMR method(qHNMR)was used to measure the trigonelline content in the leaves of six species of the Annona *** methodology employed compared the intensities of the signals at δ9.14(H-2)andδ0.00,the internal standard TSP-d_(4).This measuring method was able to establish the concentration of trigonelline in the range from 0.67 to 10.04 mg·g^(-1) depending on the investigated extract.

关键词： trigonelline Annona quantitative^(1)H NMR

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Stability of Brazilian Seasonally Dry Forests under Climate Change: Inferences for Long-Term Conservation

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American journal of Plant Sciences 2013年第4期4卷 792-805页

作者： Rosane G. Collevatti Matheus souza Lima-Ribeiro josé Alexandre F. Diniz-filho Guilherme Oliveira Ricardo Dobrovolski Levi Carina Terribile departamento de Ecologia Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Genética & Biodiversidade Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Macroecologia Universidade Federal de Goiás Jataí Brazil

We identified climatically stable areas of seasonally dry forests (SDFs) from Central Brazil through time and assessed the effectiveness of the current reserves network in representing these climatically stable areas, as well as areas of high suitability in the present or in the future only. We used an ensemble approach based on several methods for ecological niche modelling (ENMs) to obtain potential distributions 16 SDF’ species for past (last glacial maximum), present, and future (end of XXI century) climate scenarios. We then computed how many current Brazilian reserves matched both stable areas (suitable areas for all time periods), present and future geographical ranges alone for each species, in a multi-level gap analysis. We found range shifts due to climate changes for SDF’ species. Although the future geographical range and stable areas for all analyzed species matched at least with one reserve, many protected areas will lose importance in protecting suitable areas for species in the future. Moreover, the current Brazilian reserves cover only a small amount of their climatically stable areas. However, some reserves will be suitable for many SDF’ species (90%) at the same time, but climatically stable for only half of them. Our findings show that vegetation community from SDFs may persist in Brazilian territories until the end of XXI century, and challenges about long-term conservation of the SDFs may be partially reached with already existing Brazilian reserve network, however the reserves should be connected to permit habitat tracking.

关键词： Cerrado Biome Ecological Niche Modelling Global Climate Change Quaternary Climate Change Gap Analysis

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Trichomonas vaginalis perturbs the junctional complex in epithelial cells

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Cell Research 2005年第9期 29-41页

作者： Rodrigo Furtado MAdeIRO da COSTA,Wanderley de souza,Marlene BENCHIMOL,john F ALdeRETE,josé Andrés MORGADO-DíAZ Programa de Pós Graduao em Ciências Morfológicas Universidade Federal do Rio de janeiro Rio de janeiro Rj 20231- 050 Brazil Grupo de Biologia Estrutural Diviso de Biologia Celular Centro de Pesquisa Instituto Nacional de Cancer Rio de janeiro Rj 20231-050 Brazil Grupo de Biologia Estrutural Diviso de Biologia Celular Centro de Pesquisa Instituto Nacional de Cancer Rio de janeiro Rj 20231-050 Brazil Laboratório de Ultraestrutura Celular Hertha Meyer Instituto de Biofísica Carlos Chagas filho Universidade Federal do Rio de janeiro Centro de Ciências da Saúde Rio de janeiro Rj 21944-900 Brazil Laboratório de Ultraestrutura Celular Universidade Santa úrsula Rio de janeiro Rj 22231-010 Brazil department of Microbiology University of Texas Health Science Center San Antonio TX 78229-3900 USA Grupo de Biologia Estrutural Diviso de Biologia Celular Centro de Pesquisa Instituto Nacional de Cancer Rio de janeiro Rj 20231-050 Brazil

Trichomonas vaginalis, a protist parasite of the urogenital tract in humans, is the causative agent of trichomonosis, which in recent years have been associated with the cervical cancer development. In the present study we analyzed the modifications at the junctional complex level of Caco-2 cells after interaction with two isolates of T. vaginalis and the influence of the iron concentration present in the parasite’s culture medium on the interaction effects. Our results show that T. vaginalis adheres to the epithelial cell causing alterations in the junctional complex, such as: (a) a decrease in transepithelial electrical resistance; (b) alteration in the pattern of junctional complex proteins distribution as observed for E-cadherin, occludin and ZO-1; and (c) enlargement of the spaces between epithelial cells. These effects were dependent on (a) the degree of the parasite virulence isolate, (b) the iron concentration in the culture medium, and (c) the expression of adhesin proteins on the parasite surface.

关键词： Trichomonas vaginalis Caco-2 junctional complex proteins transepithelial electrical resistance adhesins.

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SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

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journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima juliano P.souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado joséC.Alves-filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-junior Rene D.R.Oliveira Sean P.j.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

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Helicobacter pylori infection in pregnant women:Gastrointestinal symptoms and pregnancy-related disorders

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World journal of Clinical Infectious Diseases 2023年第5期13卷 49-57页

作者： Luana Kauany de SáSantos jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da Costa Vinícius Lima de souza Gonçalves Ronaldo Teixeira da Silva júnior Marcel Silva Luz Fabian Fellipe bueno Lemos Samuel Luca Rocha Pinheiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil

Helicobacter pylori(***)is a gram-negative,flagellated and spiral-shaped bacterial pathogen that impacts approximately 46%among pregnant women globally and has been associated with various maternal-fetal *** deficiency anemia,fetal growth restriction,cardiovascular diseases,and insufficient nutrient absorption can be observed in pregnant women,as well as miscarriages and pregnancy-specific hypertensive disease,such as ***,the evidence supports the influence of *** infection on fetal implantation/placentation failure,and positive strains of the cytotoxin-associated gene A of *** were reported as the most prevalent in these ***,current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum,characterized by frequent nausea and *** the diagnosis of this bacterial infection,non-invasive approaches such as stool antigen test,urea breath test,and serological tests are more accepted during pregnancy,as they are easy to carry out and ***,the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child,with pharmacological intervention depending on the clinical presentation.

关键词： Helicobacter pylori Pregnancy Hyperemesis gravidarum Iron deficiency anemia Pre-eclampsia Fetal growth restriction Miscarriage

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Immune response to Helicobacter pylori infection and gastric cancer development

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World journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms

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Bee venom acupuncture reduces neuroinflammation modulating microglia/macrophage phenotype polarization in spinal cord injury compression model

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Neuroimmunology and Neuroinflammation 2019年第11期6卷 1-13页

作者： Raquel do Nascimento de souza júlia Miccolis Azevedo Lopes Lívia da Rocha Natalino Monteiro Raiana Andrade Quintanilha Barbosa Gabriela Hollmann Silvana Allodi Luis Carlos Reis MagdaAlves de Medeiros department of Physiological Sciences Institute of Biology and Health SciencesFederal Rural University of Rio de JaneiroSeropedica 23897-000RJBrazil Carlos Chagas filho Institute of Biophysics Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil.

Aim: The present study aimed to examine whether apipuncture (stimulation of acupuncture points with bee venom)at ST36 and GV3 acupoints promotes neuroprotection and reduces neuroinflammation by modulating M1 and M2 phenotype ***: Wistar rats were treated with bee venom (BV) (0.08 mg/kg) injection at acupoints ST36 and GV3 [BV (ST36 + GV3)-spinal cord injury (SCI)] or BV injection at non-acupoints [BV (NP)-SCI] or no treatment (CTL-SCI)after SCI by compression. The spinal cord mRNA expression of iNOS, Arg-1 and TGF-β was measured by real time PCR and the levels of IBA-1;BCL-2;NeuN e CNPase was measured by western blotting. Locomotor performance was measured by Basso, Beattie, and Bresnahan (BBB) and grid-walking ***: Apipuncture treatment was able to (1) ameliorate locomotor performance;(2) reduce inflammatory markers (Cox-2 levels) and activation of microglia and macrophages;(3) reduce the polarization of the M1 phenotype marker (iNOS) and increase M2 (Arg-1 and TGF-β) phenotypic markers;(4) promote neuroprotection by reducing the death of neurons and oligodendrocytes;and (5) increase the expression of the anti-apoptotic factor ***: Apipuncture treatment induces locomotor recovery and neuroprotection after the compression model of spinal cord injury. Further, it reduces neuroinflammation by decreasing M1 polarization and increasing M2 phenotype.

关键词： Acupuncture bee venom spinal cord injury compression microglia macrophage neuroinflammation

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Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil

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Infectious Diseases of Poverty 2020年第1期9卷 36-45页

作者： Luciana Regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição souza Yuri Scheidegger de Castro Letícia Silva Nascimento juliana Azevedo da Silva Edilbert Pellegrini Nahn junior Wilmar Dias da Silva Alba Lucínia Peixoto-Rangel Laboratory of Recognition Biology Center of Biosciences and BiotechnologyState University of Northern Rio de JaneiroCampos dos GoytacazesRJBrazil Campos Medical School Campos dos GoytacazesRJBrazil Laboratory of Immunochemistry Butantan InstituteSão PauloSPBrazil

Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in *** with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of *** we investigated the possible influence of ***/*** co-parasitism on the manifestation of leprosy and its clinical ***:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de janeiro state,southeast Brazil,from August 2015 to december 2019 and clinically diagnosed for *** were selected based on the presence(patients)or absence(healthy controls)of the leprosy *** of patients were also recruited for this *** samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ***,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ***-PGL-1 IgG and IgM levels were compared using one-way ANOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for *** *** risk of *** infection for leprosy disease was assessed using Fisher’s ***:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous *** serologic prevalence for *** infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this *** leprosy risk increase in *** seropositive individuals was two-fold(odds ratio[OR]=2.055;95% c

关键词： Leprosy Toxoplasmosis Coinfection Co-immunomodulation Immunoglobulins Immune response

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Performance of a Nonwoven Geotextile Reinforced Wall with Unsaturated Fine Backfill Soil

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journal of Civil Engineering and Architecture 2013年第10期7卷 1253-1259页

作者： Femando Henrique Martins Portelinha Benedito de souza bueno jorge Gabriel Zomberg department of Civil Engineering Federal University of Sao Carlos Sao Carlos/SP 13564-350 Brazil Sao Carlos Engineering School University of Sao Paulo Sao Carlos/SP 13566-536 Brazil Civil Engineering department University of Texas at Austin Austin/TX 78712-0280 USA

The use of marginal backfills in GSE (geosynthetic stabilized earth) walls has not been recommended by different standards specifications. Restrictions are motivated by the poor hydraulic conductivity of fine soils that are capable of developing of water pressures. However, the use of granular materials can expend the cost of the construction. As a result, local soils, granular or not, have been increasingly used. Unsaturated conditions of fine soils may result in convenient performance even using extensible reinforcements. This paper evaluates the performance of a full scale model of a nonwoven geotextile reinforced wall constructed with fine grained soil backfill. The unsaturated condition was maintained and matric suctions, displacements and reinforcement strains were monitored during the test. Results have shown that the unsaturated condition of the backfill allowed maximum reinforcement peak strain of 0.4 %. For the case of a wrap faced wall on a firm foundation the performance and good agreement between measured strains and factors of safety from limit equilibrium analyses have shown the maintenance of unsaturated conditions as an economical alternative to the use of high quality fill.

关键词：土工合成材料非织造土工布不饱和性能回填墙面颗粒状物料加筋

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