Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil

作     者：Luciana Regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição Souza Yuri Scheidegger de Castro Letícia Silva Nascimento Juliana Azevedo da Silva Edilbert Pellegrini Nahn Junior Wilmar Dias da Silva Alba Lucínia Peixoto-Rangel Oliveira Luciana Regina Pereira;Martins Livia Mattos;Souza Rebeka da Concei??o;de Castro Yuri Scheidegger;Nascimento Letícia Silva;da Silva Juliana Azevedo;Junior Edilbert Pellegrini Nahn;da Silva Wilmar Dias;Peixoto-Rangel Alba Lucínia

作者机构：Laboratory of Recognition BiologyCenter of Biosciences and BiotechnologyState University of Northern Rio de JaneiroCampos dos GoytacazesRJBrazil Campos Medical SchoolCampos dos GoytacazesRJBrazil Laboratory of ImmunochemistryButantan InstituteSão PauloSPBrazil 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2020年第9卷第1期

页      面：36-45页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：This project has been supported by Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro(FAPERJ)-APQ-1 E-26/111.196/2014 

主　　题：Leprosy Toxoplasmosis Coinfection Co-immunomodulation Immunoglobulins Immune response 

摘      要：Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in *** with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of *** we investigated the possible influence of ***/*** co-parasitism on the manifestation of leprosy and its clinical ***:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de Janeiro state,southeast Brazil,from August 2015 to December 2019 and clinically diagnosed for *** were selected based on the presence(patients)or absence(healthy controls)of the leprosy *** of patients were also recruited for this *** samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ***,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ***-PGL-1 IgG and IgM levels were compared using one-way ANOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for *** *** risk of *** infection for leprosy disease was assessed using Fisher’s ***:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous *** serologic prevalence for *** infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this *** leprosy risk increase in *** seropositive individuals was two-fold(odds ratio[OR]=2.055;95% c