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The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis

Neural Regeneration Research 2023年第7期18卷 1427-1433页

作者： ilaria Martinelli Elisabetta Zucchi Cecilia Simonini Giulia Gianferrari Giovanna Zamboni Marcello Pinti Jessica Mandrioli Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly Department of Neurosciences Azienda Ospedaliero-Universitaria di ModenaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly

Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases,the discovery of this gene has been crucial for amyotrophic lateral sclerosis *** the identification of superoxide dismutase 1 in 1993,the field of amyotrophic lateral sclerosis genetics has considerably widened,improving our understanding of the diverse pathogenic basis of amyotrophic lateral *** this review,we focus on cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis *** has mostly reported that cognition remains intact in superoxide dismutase 1-amyotrophic lateral sclerosis patients,but recent reports highlight frontal lobe function frailty in patients carrying different superoxide dismutase 1-amyotrophic lateral sclerosis *** thoroughly reviewed all the various mutations reported in the literature to contribute to a comprehensive database of superoxide dismutase 1-amyotrophic lateral sclerosis genotype-phenotype *** a resource could ultimately improve our mechanistic understanding of amyotrophic lateral sclerosis,enabling a more robust assessment of how the amyotrophic lateral sclerosis phenotype responds to different variants across genes,which is important for the therapeutic strategy targeting genetic *** in superoxide dismutase 1-amyotrophic lateral sclerosis deserves further longitudinal research since this peculiar frailty in patients with similar mutations can be conditioned by external factors,including environment and other unidentified agents including modifier genes.

关键词： amyotrophic lateral sclerosis cognitive impairment genotype-phenotype correlation superoxide dismutase 1

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Association between non-alcoholic fatty liver disease and obstructive sleep apnea

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World Journal of Gastroenterology 2020年第20期26卷 2669-2681页

作者： ilaria Umbro Valerio Fabiani Mario Fabiani Francesco Angelico Maria Del Ben Department of Anatomical HistologicalForensic Medicine and Orthopedic SciencesSapienza University of RomeRome 00161Italy Department of Neurosciences Mental Health and Sensory OrgansSapienza University of RomeRome 00123Italy Department of Sense Organs Sapienza University of RomeRome 00161Italy Department of Public Health and Infectious Diseases Sapienza University of RomeRome 00161Italy Department of Clinical InternalAnesthetic and Cardiovascular SciencesSapienza University of RomeRome 00161Italy

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is an emerging liver disease and currently the most common cause of incidental abnormal liver *** pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration,inflammation,oxidative stress and progressive fibrosis have been *** sleep apnea(OSA)may be linked with the pathogenesis and the severity of *** To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure(CPAP)*** A Pub Med search was conducted using the terms"non-alcoholic fatty liver disease AND(obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea)".Research was limited to title/abstract of articles published in English in the last 5 years;animal and child studies,case reports,commentaries,letters,editorials and meeting abstracts were not *** were extracted on a standardized data collection table which included:First author,publication year,country,study design,number of patients involved,diagnosis and severity of OSA,diagnosis of NAFLD,patient characteristics,results of the *** total,132 articles were initially retrieved on Pub Med search and 77 in the last five *** removal of irrelevant studies,13 articles were included in the qualitative *** was a total of 2753 participants across all the studies with a mean age between 42 and 58 *** proportion of males ranged from21%to 87.9%and the mean body mass index ranged from 24.0 to 49.9 kg/*** results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA,even in the absence of coexisting comorbidities such as obesity or metabolic ***,the severity of NAFLD is associated with the increase in OSA *** CPAP treatment,although not always decisive,may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular *** In

关键词： Continuous positive air pressure Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Obstructive sleep apnea Obstructive sleep disorders Sleep apnea

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Liver transplantation for hepatocellular carcinoma: Where do we stand?

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World Journal of Gastroenterology 2019年第21期25卷 2591-2602页

作者： Francesco Santopaolo ilaria Lenci Martina Milana Tommaso Maria Manzia Leonardo Baiocchi Hepatology Unit Department of MedicinePoliclinico Universitario Tor VergataRome 00133Italy Transplant Surgery Unit Department of SurgeryPoliclinico Universitario Tor VergataRome 00133Italy

Hepatocellular carcinoma represents an important cause of morbidity and mortality worldwide. It is the sixth most common cancer and the fourth leading cause of cancer death. Liver transplantation is a key tool for the treatment of this disease in human therefore hepatocellular carcinoma is increasing as primary indication for grafting. Although liver transplantation represents an outstanding therapy for hepatocellular carcinoma, due to organ shortage, the careful selection and management of patients who may have a major survival benefit after grafting remains a fundamental question. In fact, only some stages of the disease seem amenable of this therapeutic option, stimulating the debate on the appropriate criteria to select candidates. In this review we focused on current criteria to select patients with hepatocellular carcinoma for liver transplantation as well as on the strategies (bridging) to avoid disease progression and exclusion from grafting during the stay on wait list. The treatments used to bring patients within acceptable criteria (down-staging), when their tumor burden exceeds the standard criteria for transplant, are also reported. Finally, we examined tumor reappearance following liver transplantation. This occurrence is estimated to be approximately 8%-20% in different studies. The possible approaches to prevent this outcome after transplant are reported with the corresponding results.

关键词： Hepatocellular carcinoma Liver transplantation Bridging Down-staging Milan Criteria

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Synthesis of palladium-rhodium bimetallic nanoparticles for formic acid dehydrogenation

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Journal of Energy Chemistry 2021年第1期30卷 301-309,I0010页

作者： ilaria Barlocco Sofia Capelli Elisa Zanella Xiaowei Chen Juan JDelgado Alberto Roldan Nikolaos Dimitratos Alberto Villa Dipartimento di Chimica Universitàdegli Studi di MilanoMilan I-20133Italy Departamento de Ciencia de los Materiales Ingeniería Metalúrgica y Química InorgánicaFacultad de CienciasUniversidad de CádizCampus Río San PedroPuerto Real(Cádiz)E-11510Spain School of Chemistry Cardiff UniversityMain BuildingPark PlaceCF103AT CardiffUnited Kingdom Dipartimento di Chimica Industriale e dei Materiali Alma Mater Studiorum Universitàdi BolognaViale Risorgimento 4I-40136 BolognaItaly

Herein,we report for the first time the synthesis of preformed bimetallic Pd-Rh nanoparticles with different Pd:Rh ratios(nominal molar ratio:80-20,60-40,40-60,20-80) and the corresponding Pd and Rh monometallic ones by sol immobilization using polyvinyl alcohol(PVA) as protecting agent and NaBH4 as reducing agent,using carbon nanofibers with high graphitization degree(HHT) as the desired *** synthesized catalysts were characterized by means of Transmission Electron Microscopy(TEM) and inductively coupled plasma optical emission spectroscopy(ICP-OES).TEM shows that the average particle size of the Pd-Rh nanoparticles is the range of 3-4 nm,with the presence of few large agglomerated *** bimetallic catalysts,EDX-STEM analysis of individual nanoparticles demonstrated the presence of random-alloyed nanoparticles even in all cases Rh content is lower than the nominal one(calculated Pd:Rh molar ratio:90-10,69-31,49-51,40-60).The catalytic performance of the Pd-Rh catalysts was evaluated in the liquid phase dehydrogenation of formic acid to *** was found that Pd-Rh molar ratio strongly influences the catalytic ***-rich catalysts were more active than Rh-rich ones,with the highest activity observed for Pd90:Rh10(1792 h^(-1)),whereas Pd69:Rh31(921 h^(-1)) resulted the most stable during recycling ***,Pd90:Rh10 was chosen as a representative sample for the liquid-phase hydrogenation of muconic acid using formic acid as hydrogen donor,showing good yield to adipic acid.

关键词： Palladium Rhodium Alloy Formic acid Hydrogen Muconic acid

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Current guidelines for the management of non-alcoholic fatty liver disease:A systematic review with comparative analysis

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World Journal of Gastroenterology 2018年第30期24卷 3361-3373页

作者： Simona Leoni Francesco Tovoli Lucia Napoli ilaria Serio Silvia Ferri Luigi Bolondi Department of Medical and Surgical Sciences (DIMEC) Division of Internal MedicineUniversity of Bologna

The current epidemic of non-alcoholic fatty liver disease(NAFLD) is reshaping the field of hepatology all around the *** widespread diffusion of metabolic risk factors such as obesity,type2-diabetes mellitus,and dyslipidemia has led to a worldwide diffusion of *** parallel to the increased availability of effective anti-viral agents,NAFLD is rapidly becoming the most common cause of chronic liver disease in Western Countries,and a similar trend is expected in Eastern Countries in the next *** epidemic and its consequences have prompted experts from all over the word in identifying effective strategies for the diagnosis,management,and treatment of *** scientific societies from Europe,America,and Asia-Pacific regions have proposed guidelines based on the most recent evidence about *** guidelines are consistent with the key elements in the management of NAFLD,but still,show significant difference about some critical *** reviewed the current literature in English language to identify the most recent scientific guidelines about NAFLD with the aim to find and critically analyse the main *** distinguished guidelines from 5 different scientific societies whose reputation is worldwide recognised and who are representative of the clinical practice in different geographical *** were noted in: the definition of NAFLD,the opportunity of NAFLD screening in high-risk patients,the noninvasive test proposed for the diagnosis of NAFLD and the identification of NAFLD patients with advanced fibrosis,in the follow-up protocols and,finally,in the treatment strategy(especially in the proposed pharmacological management).These difference have been discussed in the light of the possible evolution of the scenario ofNAFLD in the next years.

关键词： Non-alcoholic fatty liver disease Metformin Liver steatosis Liver biopsy Non-invasive diagnosis Pioglitazone Clinical guidelines

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Identify multiple myeloma stem cells: Utopia?

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World Journal of Stem Cells 2015年第1期7卷 84-95页

作者： ilaria Saltarella Aurelia Lamanuzzi Antonia Reale Angelo Vacca Roberto Ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine "G. Baccelli" University of Bari "Aldo Moro" Medical School Policlinico I-70124 Bari Italy

Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs.

关键词： Bone marrow microenvironment Cancerstem cells Multiple myeloma Stem cells niche Stemness

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Current guidelines for diagnosis and management of hepatic involvement in hereditary hemorrhagic teleangiectasia

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World Journal of Hepatology 2023年第5期15卷 675-687页

作者： Luca Ielasi Matteo Tonnini Fabio Piscaglia ilaria Serio Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy Department of Internal Medicine Ospedale per gli Infermi di FaenzaFaenza 48018Italy Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy

Hereditary hemorrhagic teleangiectasia(HHT),also known as Rendu-Osler-Weber syndrome,is the most common cause of hepatic vascular malformations in *** vascular shunts(arteriovenous,arterioportal or portovenous)lead to different clinical *** though no hepatic-related symptoms are reported in the majority of cases,the severity of liver disease could lead to refractory medical conditions,in some cases requiring liver *** aim of this manuscript is to provide an updated overview of the current evidence regarding the diagnosis and treatment of HHT liver involvement and liver-related complications.

关键词： involvement diagnosis hemorrhagic

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Sequence of events leading to primary biliary cholangitis

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世界胃肠病学杂志:英文版 2023年第37期29卷 5305-5312页

作者： ilaria Lenci Paola Carnì Martina Milana Agreta Bicaj Alessandro Signorello Leonardo Baiocchi Hepatology Unit University of Tor VergataRome 00133Italy Postgraduate School in Hepato/Gastroenterology Catholic University Our Lady of Good CounselTirana 1004Albania

Primary biliary cholangitis(PBC)is a chronic cholestatic liver disease that is observed more frequently in middle-aged *** disorder is considered an autoimmune disease,since liver injury is sustained by the presence of selfdirected antimitochondrial antibodies targeting the bile duct *** prognosis may vary depending on an early diagnosis and response to ***,nearly a third of patients can progress to liver cirrhosis,thus requiring a liver *** immunosuppressive therapies,commonly employed for other autoimmune diseases,have limited effects on *** fact,dramatic functional changes that occur in the biliary epithelium in the course of inflammation play a major role in perpetuating the *** this minireview,after a background on the disease and possible predisposing factors,the sequential cooperation of cellular/molecular events leading to end-stage PBC is discussed in *** rise and maintenance of the autoimmune process,as well as the response of the biliary epithelia during inflammatory injury,are key factors in the progression of the *** so-called“ductular reaction(DR)”,intended as a reactive expansion of cells with biliary phenotype,is a process frequently observed in PBC and partially ***,recent findings suggest a strict relationship between this pathological picture and the progression to liver fibrosis,cell senescence,and loss of biliary *** these issues(onset of chronic inflammation,changes in secretive and proliferative biliary functions,DR,and its relationship with other pathological events)are discussed in this manuscript in an attempt to provide a snapshot,for clinicians and researchers,of the most relevant and sequential contributors to the progression of this human cholestatic *** believe that interpreting this disorder as a multistep process may help identify possible therapeutic targets to prevent evolution to severe disease.

关键词： Primary biliary cholangitis Cholangiocyte Biliary secretion Biliary proliferation Ductular reaction Antimitochondrial antibody Cellular senescence Liver fibrosis

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Plastic occurrence,sources,and impacts in Antarctic environment and biota

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Water Biology and Security 2022年第2期1卷 60-71页

作者： Gabriella Caruso Elisa Bergami Neelu Singh ilaria Corsi Institute of Polar Sciences National Research CouncilMessinaItaly British Antarctic Survey Natural Environment Research CouncilHigh CrossMadingley RoadCambridgeCB30ETUK Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly Norwegian Polar Institute LongyearbyenNorway Department of Physical Earth and Environmental Sciences University of Siena53100SienaItaly

Several studies have documented that plastic pollution is affecting one of the most remote and pristine regions of our planet,*** of different size and polymeric composition have been retrieved in Antarctic sea ice,surface waters and sediments,with microplastics(mostly fibers)found both in terrestrial and marine *** evidence raises concerns about potential detrimental effects on biodiversity and ecosystem *** present review aims to report the most up-to-date knowledge on occurrence and distribution of plastic pollution in the Antarctic environment and biota including interaction with microorganisms,potential sources,and its impact on Antarctic *** understanding of plastic pollution in this polar region will help us define the human footprint in Antarctica and predict future ecological risks.

关键词： Anthropogenic impact Contamination Microplastics Southern ocean Antarctica Occurrence Sources Ecotoxicity Colonization Biosecurity

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Choroidal vascularity index in thyroidassociated ophthalmopathy:a crosssectional study

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Eye and Vision 2021年第4期8卷 175-182页

作者： Pasquale Loiudice Marco Pellegrini Michele Marinò Barbara Mazzi ilaria Ionni Giuseppe Covello Michele Figus Marco Nardi Giamberto Casini Department of Surgical Ophthalmology UnitMedicalMolecular and Critical Area PathologyUniversity of PisaVia Savi1056126 PisaItaly Ophthalmology Unit S.Orsola-Malpighi University HospitalUniversity of BolognaBolognaItaly Department of Clinical and Experimental Medicine Endocrinology Unit IUniversity Hospital of PisaPisaItaly

Background:Hemodynamic changes have been observed in patients with Graves’*** aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVI)in patients with thyroidassociated ophthalmopathy(TAO).Methods:In this cross-sectional observational study,40 patients affected by TAO were *** healthy individuals,matched for age and sex,served as *** enhanced-depth imaging optical coherence tomography scans were obtained from all *** were binarized using the ImageJ software and luminal area(LA)and total choroidal area(TCA)were *** was calculated as the proportion of LA to *** relation between CVI or subfoveal choroidal thickness(SFCT)and clinical activity score,exophthalmometric value,diplopia status,gender,and age was ***:CVI was significantly higher in patients with TAO(P=0.004).No significant difference was observed in SFCT(P=0.200)and TCA(P=0.153)comparing TAO patients and healthy *** was significantly higher in TAO group(P=0.045).On multiple regression analysis,CVI was associated with TCA(P=0.043).No association was found between SFCT or CVI and TCA,clinical activity score,exophthalmometric value,Inami value,diplopia status,gender or age(P>0.05).Conclusions:This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

关键词： Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness Thyroid-associate ophthalmopathy

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