Association between non-alcoholic fatty liver disease and obstructive sleep apnea

作     者：Ilaria Umbro Valerio Fabiani Mario Fabiani Francesco Angelico Maria Del Ben 

作者机构：Department of AnatomicalHistologicalForensic Medicine and Orthopedic SciencesSapienza University of RomeRome 00161Italy Department of NeurosciencesMental Health and Sensory OrgansSapienza University of RomeRome 00123Italy Department of Sense OrgansSapienza University of RomeRome 00161Italy Department of Public Health and Infectious DiseasesSapienza University of RomeRome 00161Italy Department of ClinicalInternalAnesthetic and Cardiovascular SciencesSapienza University of RomeRome 00161Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第20期

页      面：2669-2681页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100213[医学-耳鼻咽喉科学] 10[医学] 

主　　题：Continuous positive air pressure Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Obstructive sleep apnea Obstructive sleep disorders Sleep apnea 

摘      要：BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is an emerging liver disease and currently the most common cause of incidental abnormal liver *** pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration,inflammation,oxidative stress and progressive fibrosis have been *** sleep apnea(OSA)may be linked with the pathogenesis and the severity of *** To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure(CPAP)*** A Pub Med search was conducted using the termsnon-alcoholic fatty liver disease AND(obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea).Research was limited to title/abstract of articles published in English in the last 5 years;animal and child studies,case reports,commentaries,letters,editorials and meeting abstracts were not *** were extracted on a standardized data collection table which included:First author,publication year,country,study design,number of patients involved,diagnosis and severity of OSA,diagnosis of NAFLD,patient characteristics,results of the *** total,132 articles were initially retrieved on Pub Med search and 77 in the last five *** removal of irrelevant studies,13 articles were included in the qualitative *** was a total of 2753 participants across all the studies with a mean age between 42 and 58 *** proportion of males ranged from21%to 87.9%and the mean body mass index ranged from 24.0 to 49.9 kg/*** results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA,even in the absence of coexisting comorbidities such as obesity or metabolic ***,the severity of NAFLD is associated with the increase in OSA *** CPAP treatment,although not always decisive,may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular *** In