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Clinical efficacy of Gamma Knife® combined with transarterial chemoembolization and immunotherapy in the treatment of primary liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1601-1608页

作者： Guo-Feng wang Chang-Xin Shu Xiao-Dong Cai hong-bo wang Jian-hong Xu Yu-Qing Jia Department of General Surgery Yangzhou Friendship Hospital Affiliated to Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND This study was designed to investigate the clinical efficacy and safety of Gamma Knife®combined with transarterial chemoembolization(TACE)and immunotherapy in the treatment of primary liver *** To investigate the clinical efficacy and safety of Gamma Knife®combined with TACE and immune-targeted therapy in the treatment of primary liver *** Clinical data from 51 patients with primary liver cancer admitted to our hospital between May 2018 and October 2022 were retrospectively *** patients underwent Gamma Knife®treatment combined with TACE and *** clinical efficacy,changes in liver function,overall survival(OS),and progression-free survival(PFS)of patients with different treatment responses were evaluated,and adverse reactions were *** The last follow-up for this study was conducted on October 31,*** evaluation of the 51 patients with primary liver cancer revealed a partial response(PR)in 27 patients,accounting for 52.94%(27/51);stable disease(SD)in 16 patients,accounting for 31.37%(16/51);and progressive disease(PD)in 8 patients,accounting for 15.69%(8/51).The objective response rate was 52.94%,and the disease control rate was 84.31%.Alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alpha-fetoprotein isoform levels decreased after treatment compared with pretreatment(all P=0.000).The median OS was 26 months[95%confidence interval(95%CI):19.946-32.054]in the PR group and 19 months(95%CI:14.156-23.125)in the SD+PD group,with a statistically significant difference(P=0.015).The median PFS was 20 months(95%CI:18.441-34.559)in the PR group and 12 months(95%CI:8.745-13.425)in the SD+PD group,with a statistically significant difference(P=0.002).Common adverse reactions during treatment included nausea and vomiting(39.22%),thrombocytopenia(27.45%),and leukopenia(25.49%),with no treatment-related deaths *** Gamma Knife®combined with TACE and immune-targeted th

关键词： Gamma Knife® Transarterial chemoembolization Immunotherapy Primary liver cancer Liver function

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Novel conductive polypyrrole/silk fibroin scaffold for neural tissue repair

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Neural Regeneration Research 2018年第8期13卷 1455-1464页

作者： Ya-hong Zhao Chang-Mei Niu Jia-Qi Shi Ying-Yu wang Yu-Min Yang hong-bo wang Key Laboratory of Science and Technology of Eco-textiles Ministry of Education Jiangnan University Key Laboratory of Neuroregeneration Co-innovation Center of Neuroregeneration Nantong University Medical School Nantong University Wen Zheng College Soochow University

Three dimensional（3D） bioprinting, which involves depositing bioinks（mixed biomaterials） layer by layer to form computer-aided designs, is an ideal method for fabricating complex 3D biological structures. However, it remains challenging to prepare biomaterials with micro-nanostructures that accurately mimic the nanostructural features of natural tissues. A novel nanotechnological tool, electrospinning, permits the processing and modification of proper nanoscale biomaterials to enhance neural cell adhesion, migration, proliferation, differentiation, and subsequent nerve regeneration. The composite scaffold was prepared by combining 3D bioprinting with subsequent electrochemical deposition of polypyrrole and electrospinning of silk fibroin to form a composite polypyrrole/silk fibroin scaffold. Fourier transform infrared spectroscopy was used to analyze scaffold composition. The surface morphology of the scaffold was observed by light microscopy and scanning electron microscopy. A digital multimeter was used to measure the resistivity of prepared scaffolds. Light microscopy was applied to observe the surface morphology of scaffolds immersed in water or Dulbecco＇s Modified Eagle＇s Medium at 37℃ for 30 days to assess stability. Results showed characteristic peaks of polypyrrole and silk fibroin in the synthesized conductive polypyrrole/silk fibroin scaffold, as well as the structure of the electrospun nanofiber layer on the surface. The electrical conductivity was 1 × 10^-5–1 × 10^-3 S/cm, while stability was 66.67%. A 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphenyl-2-H-tetrazolium bromide assay was employed to measure scaffold cytotoxicity in vitro. Fluorescence microscopy was used to observe Ed U-labeled Schwann cells to quantify cell proliferation. Immunohistochemistry was utilized to detect S100β immunoreactivity, while scanning electron microscopy was applied to observe the morphology of adherent Schwann cells. Results demonstrated that the polypyrrole/silk fibroin scaffo

关键词： nerve regeneration composite nanofiber scaffold three dimensional bioprinting electrospinning silk fibroin polypyrrole L929 cells conductivity Schwann cells biocompatibility nerve repair neural regeneration

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High-pressure polymorphs of LiPN2： A first-principles study

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Frontiers of physics 2018年第5期13卷 147-152页

作者： Jian Lv Xin Yang Dan Xu Yu-Xin Huang hong-bo wang Hui wang College of Materials Science and Engineering Jilin University Changchun 130012 China State Key Lab of Superhard Materials College of Physics Jilin University Changchun 130012 China College of Basic Science Changchun University of Technology Changchun 130012 China

In this work, high-pressure phase behavior of LiPN2 within 0-300 GPa was studied by using an unbiased structure searching method in combination with first-principles calculations. Three pressure- induced phase transitions were predicted, as tI16 →hR4 →cF64 → oP8 at 44, 136, and 259 GPa, respectively. The six-fold coordination environments were found for all high-pressure polymorphs, which are substantially different from the four-fold coordination environments observed in the tI16 structure. The hR4 and cF64 structures consist of close-packed PN6 and LiN6 octahedra connected by edge-sharing, whereas the oP8 structure is built up from edge- and face-sharing PN6 and LiN6 octahedra with N lying in the center of the trigonal prisms. The electronic structure analysis reveals that LiPN2 is a semiconductor within the pressure range studied and P-N and Li-N bonds are covalent and ionic, respectively. The results obtained are expected to provide insight and guidance for future experiments on LiPN2 and other alkali metal nitridophosphates.

关键词： lithium nitridophosphates phase transition high pressure first principles

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Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver

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World Journal of Gastroenterology 2008年第4期14卷 590-594页

作者： Chi-Dan Wan Chun-You wang Tao Liu Rui Cheng hong-bo wang Department of General Surgery Union HospitalTongji Medical College Huazhong University of Science andTechnology Wuhan 430022 Hubei Province China

AIM： To investigate the protective effect of target suppression of uncoupling protein-2 （UCP-2） on ischemia/ reperfusion （I/R） injury in fatty liver in ob/ob mice. METHODS： Plasmids suppressing UCP-2 expression were constructed, and transfected into fatty liver cells cultured in vitro and the ob/ob mouse I/R injury model. Serum tumor necrosis factor （TNF）-α levels, UCP-2 mRNA expression, alanine aminotransferase （ALT） levels in ob/ob mice were tested, and the pathological changes in fatty liver were observed in experimental and control groups. RESULTS： In ob/ob mouse I/R models, serum TNF-α levels were significantly higher than in normal controls. After the plasmids were transfected into the cultured cells and animal models, expression of UCP-2 rnRNA was significantly reduced as compared with that in the control group （2^1.56± 0.15 vs 2^-0.45± 0.15, p 〈 0.05）. In ob/ob mouse models, in which expression of UCP-2 was suppressed, serum ALT levels were significantly lower than those of other groups, and pathological analysis revealed that injury of liver tissues was significantly alleviated. CONCLUSION： The target suppression of UCP-2 expression in fatty liver can alleviate the I/R injury in the ob/ob mice.

关键词： ob/ob mice Fatty liver Uncoupling protein-2 Ischemia/reperfusion injury

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Impact of Hinterland Manufacturing on the Development of Container Ports: Evidence from the Pearl River Delta, China

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Chinese Geographical Science 2024年第5期34卷 886-898页

作者： hong Haolin wang bo XUE Desheng School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China

Container ports and hinterland manufacturing are two important forces of the local participation in economic *** study,taking the Pearl River Delta(PRD),China with an export-oriented economy as an example,applies Huff and panel regres-sion models to evaluate the impact of hinterland manufacturing on the development of container ports during the period of 1993–*** results show that 1)the spatial patterns of hinterlands for hub ports help to determine the distribution range and scale of economic variables that affect port throughput;2)the hinterland’s gross manufacturing output has universally positive influence on port through-put,wherein export-oriented processing and the entire manufacturing industry have significantly positive impact on port throughput in 1993–2011 and 2001–2019,respectively;3)the two internal structural factors related to an export-oriented economy,labor-intensive sectors and foreign-funded terminals,have positively moderate the direct influence of hinterland manufacturing on port *** results highlight the importance of local context in understanding port-manufacturing relationship in developing *** on our findings,policy implications are further proposed to enhance port network organization in PRD.

关键词： container ports hinterland manufacturing local development context Huff model panel regression model Pearl River Delta(PRD),China

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Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-Jie wang hong-Hua Fang Zhen-Ze Li Dan wang hong-bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size ofboron nitride is transformed from stochastic to deterministic,and the emission from individual sites becomes polychromatic to *** a result,single colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

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Characterization of the Purified Glutathione S-transferases from Two Psocids Liposcelis bostrychophila and ***

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Agricultural Sciences in China 2010年第7期9卷 1008-1016页

作者： DOU Wei XIAO Li-sha NIU Jin-zhi JIANG hong-bo wang Jin-jun Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing 400716 P.R. China

Glutathione S-transferases（GSTs） from Liposcelis bostrychophila Badonnel and ***（Enderlein）（Psocoptera：Liposcelididae） were purified by glutathione-agarose affinity chromatography,and characterized subsequently by their Michaelis-Menten kinetics toward the artificial substrates 1-chloro-2,4-dinitrobenzene（CDNB） and reduced glutathione（GSH）,*** specific activity of the purified GST toward CDNB was 2.3-fold higher in *** than in *** the specific activities of purified enzymes varied between the two species,the purification yields were ***-PAGE revealed one band at 23 kDa for both the *** of *** exhibited higher Michaelis-Menten constants（Km） but lower maximal velocity（Vmax） values than those of *** optimum pH for CDNB conjugation of *** and *** GSTs was 7.0 and 7.5,and optimum temperature was 35 and 40°C,*** kinetics showed that cibacron blue,curcumin,bromosulfalein,ethacrynic acid,and carbosulfan had excellent inhibitory effects on GSTs in both species,but the inhibitory effects of beta-cypermethrin,fenpropathrin,tetraethylthiuram disulfide,and diethyl maleate were not significant.

关键词： GSTs purification psocids xenobiotic compounds

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Microstructure and nanoindentation hardness of shot-peened ultrafine-grained low-alloy steel

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Journal of Iron and Steel Research International 2019年第5期26卷 472-482页

作者： Xiao-wei Feng Juan Xie Wen-ying Xue Yong-feng Shen hong-bo wang Zhen-yu Liu Institute of Systems Engineering of China Academy of Engineering Physics Mianyang 621999 Sichuan China Key Laboratory for Anisotropy and Texture of Materials (MOE) School of Materials Science and Engineering Northeastern University Shenyang 110819 Liaoning China The State Key Lab of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China

The effect of shot peening (SP) on microstructure and hardness of ultrafine-grained (UFG) low-alloy steel was investigated. With increasing shot-peening time from 0.5 to 1.5 h, grain size of UFG low-alloy steel decreases from 400 to 280 nm at surface whilst that of the layer with a depth of 160μm decreases from (230 ± 15) to (75 ± 5) nm. Interestingly, nanoindentation shows that hardness increases linearly with increasing the SP duration, reaching a value as high as (7.10 ± 0.1) GPa at the depth of 160 μm after the SP duration of 1.5 h. The thickness of the SP treated layer is measured as^300 μm. The Hall-Petch (H-P) relationship was established for the hardening layer. Correspondingly, abrasion resistance should be ~51% higher than that of as-prepared UFG low-alloy steel. As shown in SP processing, grain refinement is the key factor responsible for the strengthening of the studied steel.

关键词： Low-alloy steel Shot peening Grain refinement Nanoindentation Hardness

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Mechanism of counterattack of colorectal cancer cell by Fas/Fas ligand system

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World Journal of Gastroenterology 2005年第39期11卷 6125-6129页

作者： Qiang Zhu Ji-Yong Liu hong-Wei Xu Chong-Mei Yang An-Zhong Zhang Yi Cui hong-bo wang Department of Gastroenterology Shandong Provincial Hospital Jing 5 Wei 7 Road 324# Jinan 250021 Shandong Province China

AIM： To determine the role of Fas/Fas ligand （FasL） in the immune escape of colon cancer cells. METHODS： Immunohistochemistry was used to observe the expression of Fas and FasL in the tissues of colon cancer patients. In situ hybridization was used to detect the localization of FasL mRNA expression in cancer tissues. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling （TUNEL） assay and CD45 staining were performed to detect the apoptosis of tumor-infiltrating lymphocytes （TILs）. Co-culture assays of colon cancer cells （SW480） and Jurkat cells （Fas-sensitive cells） were performed to observe the counterattack of colon cancer cells to lymphocytes. RESULTS： Of 53 cases of colon carcinomas, 23 cases （43.4%） expressed Fas which was significantly lower as compared to the normal colonic mucosa （73.3%, P〈0.01）, and 45 cases （84.9%） of colon carcinomas expressed FasL, whereas only two cases （3.75%） in normal mucosa expressed FasL. FasL expression in the colon cancer cells was found to be associated with increased cell death of TIEs. The apoptotic rate of TIL in the FasL-positive staining regions of tumor cells was significantly higher than that in the FasL-negative staining region （54.84±2.79% vs 25.73±1.98%, P〈0.01）. The co-culture of SW480 cells and Jurkat cells confirmed the function of FasL on the SW480 cells. The apoptotic rates of Jurkat cells were found to be related with the amount of SW480 cells. CONCLUSION： Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression, and can counterattack the immune system via increasing FasL expression. Fas/FasL can serve as potential targets for effective antitumor therapy.

关键词： Colon neoplasm Fas system Immune counterattack

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Primary logistics planning of oil products under the imbalance of supply and demand

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Petroleum Science 2022年第4期19卷 1915-1925页

作者： Rui Qiu Yong-Tu Liang Qi Liao Ying-Qi Jiao bo-hong wang Yi Guo Hao-Ran Zhang National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China School of Petrochemical Engineering and Environment Zhejiang Ocean UniversityZhoushan316022China Sustainable Process Integration Laboratory–SPIL NETME CentreFaculty of Mechanical EngineeringBrno University of Technology–VUT BrnoTechnická2896/261669BrnoCzech Republic Oil&Gas Pipeline Control Center PipeChinaDongtucheng Road No.5Chaoyang DistrictBeijing100013PR China Center for Spatial Information Science The University of Tokyo5-1-5 KashiwanohaKashiwa-shiChiba277-8568Japan

This paper intends to complete the primary logistics planning of oil products under the imbalance of supply and demand. An integrated mathematical programming model is developed to simultaneously find the balance between supply and demand, and optimize the logistics scheme. The model takes minimum logistics cost and resource adjustment cost as the objective function, and takes supply and demand capacity, transportation capacity, mass balance, and resource adjustment rules as *** adjustment rules are considered in the model, including resource adjustment within oil suppliers,within oil consumers, and between oil consumers. The model is tested on a large-scale primary logistics of a state-owned petroleum enterprise, involving 37 affiliated refineries, 31 procurement departments,286 market depots and dedicated consumers. After the unified optimization, the supply and demand imbalance is eased by 97% and the total cost is saved by 7%, which proves the effectiveness and applicability of the proposed model.

关键词： Oil product logistics Supply and demand imbalance Petroleum enterprise Resource adjustment Mathematical Programming model

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