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Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis

Stroke & Vascular Neurology 2021年第1期6卷 109-120页

作者： hong chuan loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan Clinical Research Center Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia Clinical and Health Sciences University of South AustraliaAdelaideSouth AustraliaAustralia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman-Kampus Bandar Sungai LongKajangMalaysia Medical Department Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia School of Pharmaceutical Sciences Universiti Sains MalaysiaMindenMalaysia

There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain *** have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic *** studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the *** was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically *** stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random *** of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from *** conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of str

关键词： vitamin prevention dosage

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Prevalence of anxiety among gestational diabetes mellitus patients: A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第3期8卷 275-284页

作者： Kai Wei Lee hong chuan loh Seng Choi Chong Siew Mooi Ching Navin Kumar Devaraj Maiza Tusimin Habibah Abdul Hamid Fan Kee Hoo Department of Family Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Clinical Research Centre Hospital Seberang JayaMinistry of Health MalaysiaPerai 13700PenangMalaysia Department of Psychiatry Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Obstetrics and Gynaecology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia

BACKGROUND A diagnosis of gestational diabetes mellitus(GDM)negatively influences maternal mental *** is a lack of systematic review and meta-analysis on prevalence of anxiety among GDM *** To pool data from existing literature to determine the pooled estimates for the prevalence of anxiety among women diagnosed with *** We searched multiple databases including MEDLINE,Cinahl,PubMed and Scopus to identify studies published up to 31 October 2019 with data on the prevalence of anxiety among women diagnosed with *** were extracted from published *** were pooled using random-effects *** We reviewed 19 abstracts,retrieved 10 articles and included three studies incorporating 12744 GDM women from three *** pooled prevalence of anxiety was 29.5%(95%CI:6.9,52.0)among GDM *** Prevalence of anxiety among GDM women was *** suggest that epidemiological studies on anxiety should be conducted urgently as it merits clinical *** addition,it is important to identify factors associated with anxiety among women diagnosed with GDM.

关键词： Prevalence Anxiety Gestational diabetes Psychiatry Meta-analysis Systematic review

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Rhodium-Catalyzed Defluorinative Vinylation of gem-Difluoroalkenes for the Synthesis of 2-Fluoro-1,3-dienes

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Chinese Journal of Chemistry 2019年第10期37卷 1036-1040页

作者： Shengjin Song Huan Liu Lu Wang chuan Zhu Teck-Peng loh Chao Feng Department of Chemistry University of Science and Technology of ChinaHefeiAnhui 230026China Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingJiangsu 211816China Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University637371Singapore

Herein,we present a strategy for the formation of 2-fluoro-1,3-diene derivatives via rhodium-catalyzed direct C(sp2)-C(sp2) cross-coupling of gem-difluoroalkenes and *** merging Rh(Ⅲ)-catalyzed C(sp2)-H bond activation and nucleophilic addition/F-elimination of gem-difluoroalkene,an efficient defluorinative vinylation reaction is uncovered,which leads to the generation of 2-fluoro-1,3-dienes in moderate to good yields with excellent stereoselectivity under mild *** mechanistic study suggests unique effects of fluorine substituents which allow the reactivity profile not observed with the congeners bearing heavier halides.

关键词： diene catalyzed fluorine

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Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma

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World Journal of Gastroenterology 2021年第21期27卷 2871-2894页

作者： Zai-Sheng Ye Miao Zheng Qin-Ying Liu Yi Zeng Sheng-hong Wei Yi Wang Zhi-Tao Lin Chen Shu Qiu-hong Zheng Lu-chuan Chen Department of Gastrointestinal Surgical Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Clinical Laboratory Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Fujian Provincial Key Laboratory of Tumor Biotherapy Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina

BACKGROUND Alternative splicing(AS)increases the diversity of mRNA during transcription;it might play a role in alteration of the immune microenvironment,which could influence the development of immunotherapeutic strategies against *** To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma(STAD)from the *** overall survival data associated with AS events were used to construct a signature prognostic model for *** Differentially expressed immune-related genes were identified between subtypes on the basis of the prognostic *** STAD,2042 overall-survival-related AS events were significantly enriched in various pathways and influenced several cellular ***,the network of splicing factors and overallsurvival-associated AS events indicated potential regulatory mechanisms underlying the AS events in *** An eleven-AS-signature prognostic model(CD44|14986|ES,PPHLN1|21214|AT,RASSF4|11351|ES,KIAA1147|82046|AP,PPP2R5D|76200|ES,loh12CR1|20507|ES,CDKN3|27569|AP,UBA52|48486|AD,CADPS|65499|AT,SRSF7|53276|RI,and WEE1|14328|AP)was constructed and significantly related to STAD overall survival,immune cells,and cancer-related *** differentially expressed immune-related genes between the high-and low-risk score groups were significantly enriched in cancer-related *** This study provided an AS-related prognostic model,potential mechanisms for AS,and alterations in the immune microenvironment(immune cells,genes,and pathways)for future research in STAD.

关键词： Stomach adenocarcinoma Alternative splicing Tumor microenvironment Immune-related genes and pathways

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Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?

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World Journal of Gastroenterology 2008年第1期14卷 90-94页

作者： Hai-Tao Zheng Li-Xin Jiang Zhong-chuan Lv Da-Peng Li Chong-Zhi Zhou Jian-Jun Gao Lin He Zhi-Hai Peng Departmentof Abdominal Surgery The Affiliated Yantai YuhuangdingHospital of Qingdao University Medical College Yantai 264000Shangdong Province China Department ofGeneral Surgery The Affiliated Shanghai First People's Hospitalof Shanghai Jiaotong University Shanghai 200080 China Shanghai Bio-X Center ShanghaiJiaotong University Shanghai 200031 China

AIM: To study the candidate tumor suppressor genes (TSG) on chromosome 4p by detecting the high frequency of loss of heterozygosity (loh) in sporadic colorectal carcinoma in Chinese ***: Seven fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by PCR. PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.7 and Genotype 3.7 software were used for loh scanning and analysis. The same procedure was performed by the other six microsatellite markers spanning D4S3013 locus to make further detailed deletion mapping. Comparison between loh frequency and clinicopathological factors was performed by χ2 ***: Data were collected from all informative loci. The average loh frequency on 4p was 24.25%, and 42.3% and 35.62% on D4S405 and D4S3013 locus, respectively. Adjacent markers of D4S3013 displayed a low loh frequency (loh frequency and tumor diameter on D4S412 and D4S1546 locus (0% vs 16.67%, P = 0.041; 54.55% vs 11.11%, P = 0.034, respectively). On D4S403 locus, loh was significantly associated with tumor gross pattern (11.11%, 0, 33.33%, P = 0.030). No relationship was detected on other loci compared with clinicopathologial ***: By deletion mapping, two obvious high frequency loh regions spanning D4S3013 (4p15.2) and D4S405 (4p14) locus are detected. Candidate TSG, which is involved in carcinogenesis and progression of sporadic colorectal carcinoma on chromosome 4p, may be located between D4S3017 and D4S2933 (about 1.7 cm).

关键词： Loss of heterozygosity Colorectal carcinoma Chromosome 4p Tumor suppressor gene

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Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas

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World Journal of Gastroenterology 2006年第14期12卷 2168-2173页

作者： Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu Tsai-Yuan Hsieh De-chuan Chan Cheng-Jueng Chen Jyh-Cherng Yu Cheng-Ping Yu Horng-Jyh Harn Peng-Jen Chen Chung-Bao Hsieh Teng-Wei Chen Huan-Mieng Hsu Division of General Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Tri-Scrvice General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Buddhist Tzu-Chi General Hospital Hualien Taiwan China Department of Surgery Show Chwan Memorial Hospital Changhua Taiwan China Institute of Biomedical Sciences Academia Sinica Taipei Taiwan China

AIM： To study the role of CDH1/E-cadherin （E-cad） gene alteration profiles including mutation, loss of heterozygosity （loh）, promoter polymorphism and hypermethylation in mechanisms of CDH1 inactivation in gastric carcinoma （GC）. METHODS： Specimens were collected surgically from 70 patients with GC. Allelotyping PCR and detection of loh, denaturing high pressure liquid chromatography and DNA sequencing, restriction fragment length polymorphism analysis, methylation specific PCR, and immunohistochemical staining were used. RESULTS： Promoter polymorphism was not a major mechanism of E-cad inactivation. Only one truncating mutation was found in a diffuse type tumor （3%）. Both loh and promoter hypermethylation were major mechanisms of E-cad inactivation, but interestingly, there was a negative association between the fraction of allelic loss （loh） in tumors and hypermethylation of CDH1. Therefore loh and hypermethylation were two different tumorigenic pathways involved in GC. CONCLUSION： Given the findings that somatic mutation was extremely low and the relationship between loh and hypermethylation was inverse, any two combinations of these three factors cannot fulfill the classical two-hit hypothesis of CDH1 inactivation. Thus, other mechanisms operating at the transcriptional level or at the post-translational level might be required to induce E-cadherin inactivation.

关键词： Gastric carcinoma E-cadherin gene alteration profiles Inactivation of E-cadherin

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Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity

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World Journal of Gastroenterology 2006年第15期12卷 2437-2440页

作者： De-Sheng Weng Jin-Tian Li Shi-Juan Mai Zhi-Zhong Pan Bing-Jian Feng Qi-Sheng Feng Li-Xi Huang Qi-Jing Wang Yong-Qiang Li Xing-Juan Yu Shi-Ping Chen Jia He Jian-chuan Xia Research Section of Oncopathology State Key Laboratory of Oncology in Southern china Cancer CenterZhongshan University Guangzhou 510064 Guangdong ProvinceChina

AIM： To define the common deleted region on the long arm of haman chromosome 7q linked to primary gastric carcinomas in Chinese by loss of heterozygosity （loh） and its clinical significance. METHODS： Nine microsatellite markers distributed over chromosome 7q with an average marker density of 10cM were used to examine 70 primary gastric carcinomas for loh by PCR amplification. The PCR products were separated by electrophoresis on polyacrylamide gel. Genescan and Genotyper softwares were used to analyze loh. RESULTS： loh with at least one marker on 7q occurred in 34.3% （12/50） of the tumors. Among them, loh at D7S486 and D7S798 was higher in 24.0% （24/70） and 29.2% （5/26）, respectively. By statistical analysis we also observed an obvious genotype-phenotype correlation on 7q （P〈0.05）. The frequency of loh at D7S486 in patients with lymph node metastasis was significantly higher than that in those without lymph node metastasis （P=0.015）. CONCLUSION： The high incidence of loh at D7S486 and its correlation with poorer prognosis suggest that there might be putative tumor suppressor genes in this region involved in the tumorigenesis and progression of gastric carcinoma.

关键词： loh Chromosome 7 Gastric cancer

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Relationship　between　loss　of　heterozygosity　of　microsatellite　on　DCC　gene　and　prognosis　of　colorectal　adenocarcinoma

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World Journal of Gastroenterology 1997年第2期3卷 64-65页

作者： ZHAO Po 1, HU Ying chuan 2, WANG De Wen 3, WANG Zhi Ping 3, XU Xin Zhao 4, YI Ping Yong 2, GAO Ya Bing 3 and YANG Guang Hua 2

AIM To investigate the relationship between the loss of heterozygosity (loh) of microsatellite on the Deleted in colorectal carcinoma (DCC) gene and the prognosis of colorectal adenocarcinoma. METHODS A retrospective study of 58 cases of colorectal adenocarcinoma with the follow up data and paired control normal mucosal tissues from 1983 to 1985 from files of the Department of Pathology, West China University of Medical Sciences was carried out by PCR microsatellite method. Tumors were graded as well, moderately and poorly differentiated in 16, 35 and 7 cases, and staged as Dukes′ A, B, C in 11, 30 and 17 cases, respectively. RESULTS Heterozygosity of microsatellite was lost on DCC gene in 18 of 58 (31 0%) cases of colorectal adenocarcinoma. The 5 year survival rate between the positive and negative for loh was 44 4% and 77 5%, respectively, being significantly different ( P loh on microsatellite of DCC gene was correlated to the prognosis, but not to the differentiation ( P >0 05) and Dukes′ stage ( P >0 05) in colorectal adenocarcinoma. CONCLUSION loh of microsatellite on DCC gene may be one of malignant markers. Combined with the traditional prognostic indices, loh can predict the prognosis of colorectal adenocarcinoma.

关键词： colorectal neoplasms polymerase chain reaction oncogenes adenocarcinoma heterozygote prognosis

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人肝细胞癌4号染色体长臂缺失的细胞遗传学及分子遗传学研究

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癌症 2008年第9期27卷 998-1005页

作者：张华坤王辉云夏建川华南肿瘤学国家重点实验室

肝癌的发生是一个多基因、多途径、多阶段的复杂过程,其中染色体的缺失及对应区域的抑癌基因失活是HCC发生发展的重要生物学过程,4q在HCC中经常发生缺失,提示在4q存在肝癌相关的特异性抑癌基因。本文对HCC中有关4q缺失的研究进行了综述... 详细信息

肝癌的发生是一个多基因、多途径、多阶段的复杂过程,其中染色体的缺失及对应区域的抑癌基因失活是HCC发生发展的重要生物学过程,4q在HCC中经常发生缺失,提示在4q存在肝癌相关的特异性抑癌基因。本文对HCC中有关4q缺失的研究进行了综述,涉及细胞遗传学及分子遗传学水平,包括利用荧光原位杂交、比较基因组技术及限制性片段多态性、微卫星、单核苷酸多态性的杂合性缺失和芯片等技术所做的研究;归纳了4q在不同国家与地区缺失的热点区域,以及与HBV感染、HCC分化程度及肿瘤大小等临床参数的关系;并且列举了4q上与HCC相关的可能的抑癌基因。

关键词：肝肿瘤 4q 遗传学比较基因组杂合性缺失抑癌基因

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Correction to“Responsive hydrogel dressings for intelligent wound management”

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 147-147页

作者： Wang, Suxi Wu, Wen-Ya Yeo, Jayven Chee chuan Soo, Xiang Yun Debbie Thitsartarn, Warintorn Liu, Songlin Tan, Beng Hoon Suwardi, Ady Li, Zibiao Zhu, Qiang loh, Xian Jun

In the“CONFLICT OF INTEREST STATEMENT”section,the text“The authors declare no conflicts of interest.”is *** should be corrected to“Xian Jun loh is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this *** authors declare no competing interests.”We apologize for this error.

关键词： wound journal incomplete

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