Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis

作     者：Hong Chuan Loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan 

作者机构：Clinical Research CenterHospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia Clinical and Health SciencesUniversity of South AustraliaAdelaideSouth AustraliaAustralia Department of Pre-Clinical SciencesFaculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman-Kampus Bandar Sungai LongKajangMalaysia Medical DepartmentHospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia School of Pharmaceutical SciencesUniversiti Sains MalaysiaMindenMalaysia 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2021年第6卷第1期

页      面：109-120页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：vitamin prevention dosage 

摘      要：There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain *** have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic *** studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the *** was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically *** stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random *** of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from *** conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of str