Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma
作者机构：Department of Gastrointestinal Surgical OncologyFujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Clinical LaboratoryFujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Fujian Provincial Key Laboratory of Tumor BiotherapyFujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第21期
页 面：2871-2894页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Clinical Key Specialty Construction Program of China and Grants from the National Science Foundation Project of the Fujian Science and Technology Department,No.2017J01264 and No.2018Y0015 the Foundation for Fujian Provincial Health Technology Project,No.2019-ZQN-16,No.2019-CXB-9,and No.2019006 the Startup Fund for Scientific Research,Fujian Medical University,No.2017Q1219 and No.2017Q1220
主 题：Stomach adenocarcinoma Alternative splicing Tumor microenvironment Immune-related genes and pathways
摘 要：BACKGROUND Alternative splicing(AS)increases the diversity of mRNA during transcription;it might play a role in alteration of the immune microenvironment,which could influence the development of immunotherapeutic strategies against *** To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma(STAD)from the *** overall survival data associated with AS events were used to construct a signature prognostic model for *** Differentially expressed immune-related genes were identified between subtypes on the basis of the prognostic *** STAD,2042 overall-survival-related AS events were significantly enriched in various pathways and influenced several cellular ***,the network of splicing factors and overallsurvival-associated AS events indicated potential regulatory mechanisms underlying the AS events in *** An eleven-AS-signature prognostic model(CD44|14986|ES,PPHLN1|21214|AT,RASSF4|11351|ES,KIAA1147|82046|AP,PPP2R5D|76200|ES,LOH12CR1|20507|ES,CDKN3|27569|AP,UBA52|48486|AD,CADPS|65499|AT,SRSF7|53276|RI,and WEE1|14328|AP)was constructed and significantly related to STAD overall survival,immune cells,and cancer-related *** differentially expressed immune-related genes between the high-and low-risk score groups were significantly enriched in cancer-related *** This study provided an AS-related prognostic model,potential mechanisms for AS,and alterations in the immune microenvironment(immune cells,genes,and pathways)for future research in STAD.
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