Relationship between loss of heterozygosity of microsatellite on DCC gene and prognosis of colorectal adenocarcinoma
Relationship between loss of heterozygosity of microsatellite on DCC gene and prognosis of colorectal adenocarcinoma出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：1997年第3卷第2期
页 面：64-65页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：colorectal neoplasms polymerase chain reaction oncogenes adenocarcinoma heterozygote prognosis
摘 要：AIM To investigate the relationship between the loss of heterozygosity (LOH) of microsatellite on the Deleted in colorectal carcinoma (DCC) gene and the prognosis of colorectal adenocarcinoma. METHODS A retrospective study of 58 cases of colorectal adenocarcinoma with the follow up data and paired control normal mucosal tissues from 1983 to 1985 from files of the Department of Pathology, West China University of Medical Sciences was carried out by PCR microsatellite method. Tumors were graded as well, moderately and poorly differentiated in 16, 35 and 7 cases, and staged as Dukes′ A, B, C in 11, 30 and 17 cases, respectively. RESULTS Heterozygosity of microsatellite was lost on DCC gene in 18 of 58 (31 0%) cases of colorectal adenocarcinoma. The 5 year survival rate between the positive and negative for LOH was 44 4% and 77 5%, respectively, being significantly different ( P 0 05) and Dukes′ stage ( P 0 05) in colorectal adenocarcinoma. CONCLUSION LOH of microsatellite on DCC gene may be one of malignant markers. Combined with the traditional prognostic indices, LOH can predict the prognosis of colorectal adenocarcinoma.
维普期刊数据库