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Integrated transcriptome interactome study of oncogenes and tumor suppressor genes in breast cancer

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Genes & Diseases 2019年第1期6卷 78-87页

作者： G.Pranavathiyani Raja Rajeswary Thanmalagan Naorem Leimarembi Devi Amouda Venkatesan Centre for Bioinformatics School of Life SciencesPondicherry UniversityPondicherry 605014India

Breast cancer is the leading cause for mortality among women *** of oncogenes and tumor suppressor genes is the major reason for the cause of *** these genes will provide clues and insights about their regulatory mechanism and their interplay in *** the present study,an attempt is made to compare the functional characteristics and interactions of oncogenes and tumor suppressor genes to understand their biological role.431 breast cancer samples from seven publicly available microarray datasets were collected and analysed using GEO2R *** identified 416 differentially expressed genes were classified into five gene sets as oncogenes(OG),tumor suppressor genes(TSG),druggable genes,essential genes and other *** gene sets were subjected to various analysis such as enrichment analysis(viz.,GO,Pathways,Diseases and Drugs),network analysis,calculation of mutation frequencies and Guanine-Cytosine(GC)*** the results,it was observed that the OG were having high GC content as well as high interactions than ***,the OG are found to have frequent mutations than *** enrichment analysis results suggest that the oncogenes are involved in positive regulation of cellular protein metabolic process,macromolecule biosynthetic process and majorly in cell cycle and focal adhesion pathway in *** was also found that these oncogenes are involved in other diseases such as skin diseases and viral ***,paclitaxel and docetaxel are some of the drugs found to be enriched for oncogenes.

关键词： Breast cancer Differential gene expression Network analysis oncogenes Tumor suppressor genes

Special　Reports　and　Review　oncogenes　AND　CELL　IMMUNOGENITY：v－H－ras　SUPPRESSING　MHC　CLASS　I　EXPRESSION　IN　MOUSE　FIBROBLAST

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Chinese Journal of Cancer Research 1994年第2期6卷 149-156页

作者：吕有勇

ＳｐｅｃｉａｌＲｅｐｏｒｔｓａｎｄＲｅｖｉｅｗＯＮＣＯＧＥＮＥＳＡＮＤＣＥＬＬＩＭＭＵＮＯＧＥＮＩＴＹ：ｖ－Ｈ－ｒａｓＳＵＰＰＲＥＳＳＩＮＧＭＨＣＣＬＡＳＳＩＥＸＰＲＥＳＳＩＯＮＩＮＭＯＵＳＥＦＩＢＲＯＢＬＡＳＴＬｕ... 详细信息

ＳｐｅｃｉａｌＲｅｐｏｒｔｓａｎｄＲｅｖｉｅｗＯＮＣＯＧＥＮＥＳＡＮＤＣＥＬＬＩＭＭＵＮＯＧＥＮＩＴＹ：ｖ－Ｈ－ｒａｓＳＵＰＰＲＥＳＳＩＮＧＭＨＣＣＬＡＳＳＩＥＸＰＲＥＳＳＩＯＮＩＮＭＯＵＳＥＦＩＢＲＯＢＬＡＳＴＬｕＹｏｕｙｏｎｇ；吕有勇；Ｓｈｒａｇ...

关键词： CLASS CELL AND EXPRESSION FIBROBLAST IMMUNOGENITY IN MHC MOUSE oncogenes

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Bioinformatics Analysis Revealed Potential Tumor Suppressors (KLF4/CGN), oncogenes (SHH/LIF) and Biomarkers of Asian Stomach Adenocarcinoma

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Yangtze Medicine 2021年第2期5卷 141-156页

作者： Yang Zhou Yingying Wang Junting Cheng Ying Zhang Wenqi Cai Ziwen Han Moyu Wang Qi Huang Xiaochun Peng Hongwu Xin Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Biochemistry and Molecular Biology School of Basic Medicine Health Science Center Yangtze University Jingzhou China Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Pathophysiology School of Basic Medicine Health Science Center Yangtze University Jingzhou China

Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer and the third leading cause of cancer-related death in the world and is more common in Asia than in most Western countries. There is an urgent need to identify potential novel oncogenes and tumor suppressor genes, and biomarkers for STAD. 6652 differentially expressed genes were identified between STAD and normal samples based on the transcriptome data analysis of the TCGA and GEO databases. 13 key modules were identified in STAD by WGCNA analysis. 293 potential STAD associated genes were identified from intersection by Venn Diagram. The 293 intersected genes were enriched in cell cortex and infection by GO and KEGG analysis. 10 hub genes were identified from PPI and Cytoscape analyses of the intersected genes. KLF4/CGN low and SHH/LIF high expression were associated with short overall survival of Asian STAD patients. Bioinformatics analysis revealed potential novel tumor suppressors (KLF4/CGN), oncogenes (SHH/LIF) and biomarkers for diagnosis, therapy and prognosis of STAD, specifically for Asian patients.

关键词： WGCNA (Weighted Correlation Network Analysis) Tumor Suppressors oncogenes Stomach Adenocarcinoma (STAD) Hub Gene

Proto-oncogenes expression in the process of asthma airway remodeling

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Journal of Medical Colleges of PLA(China) 2002年第1期17卷 1-4页

作者：刘颖格戚好文李焕章 Department of Respiratory Medicine Xijing Hospital Fourth Military Medical University Xi'an 710033China

Objective: To observe the expression of proto-oncogenes in the process of airway remodeling in asthma. Methods: Guinea pig was used as an asthma model challenged by ovoglobulin. Dot-blot, Northern-blot molecular hybridization and immunohistochemistry techniques were used to detect the expression of c-fos, c-myc, c-jun and c-sis. Results: Expression of c-fos and c-myc mRNA could not be detected or detected at very low level in the control group. There were greatly increased expression of c-fos and c-myc mRNA after guinea pigs were challenged by ovoglobulin. Thirty minutes after the challenge, the expression of c-fos and c-myc mRNA reached to the peak and returned to normal level 4 h after the challenge. Immunohistochemistry studies showed that Fos, Myc, Jun and Sis expressed at low level in control group and increased after ovoglobulin stimulation. Immunohistochemically positive cells laid in the plasma of airway epithelium, in cell nucleus of bronchial epithelium and in the inflammatory cells. Pathologic studies showed there were smooth muscle thicken around bronchia and lymphocytes infiltration under mucosa or around bronchia smooth muscle. Conclusion: Proto-oncogenes expressed in airway of asthma in a guinea pig model, proto-oncogenes may have roles in the process of airway remodeling.

关键词： oncogenes asthma airway remodeling

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癌基因(oncogenes)

肿瘤防治研究 1985年第3期 127-129页

作者：杨焕明高翼之王世浚南京铁道医学院

1682年曾被称为“癌基因之年”。其后,有关癌基因的研究一直异常活跃,成果亦多,择其要者有:ras等癌基因结构与组织的阐明;c-onc假基因的发现;人基因组中c-onc的定位;conc与肿瘤染色体畸变的关系一“转位激活”机制的进一步确定;“突变... 详细信息

1682年曾被称为“癌基因之年”。其后,有关癌基因的研究一直异常活跃,成果亦多,择其要者有:ras等癌基因结构与组织的阐明;c-onc假基因的发现;人基因组中c-onc的定位;conc与肿瘤染色体畸变的关系一“转位激活”机制的进一步确定;“突变激活”机制的再次

关键词：基因组染色体组密码子颠换 oncogenes 癌基因

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癌基因(oncogenes)及其表达产物

肿瘤 1985年第1期 39-40+44页

作者：曾庆镒中国科学院上海生物化学研究所

Oncogene(以下简为One)是从Onc gene和Transforming gene等词形和词意演化而来,国内一般译为“癌基因”或“致癌基因”。 Onc本质上是DNA片段。这种DNA片段有特定的核苷酸排列顺序,能在体外把培养的易感细胞(最常用的是处于癌前阶段的NI... 详细信息

Oncogene(以下简为One)是从Onc gene和Transforming gene等词形和词意演化而来,国内一般译为“癌基因”或“致癌基因”。 Onc本质上是DNA片段。这种DNA片段有特定的核苷酸排列顺序,能在体外把培养的易感细胞(最常用的是处于癌前阶段的NIH/3T3小鼠成纤维母细胞株)转化为具有类似体内瘤细胞表型特征的转化细胞。最先仅在逆转录病毒基因组内发现了Onc,总称为V-Onc,V表示病毒。各种Onc的

关键词：表达产物 oncogenes 同源顺序逆转录病毒癌基因

致癌基因(oncogenes)研究近况(综述)

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浙江大学学报(医学版) 1985年第4期14卷 184-187+153页

作者：王纯香余应年浙江医科大学免疫研究室浙江医科大学病理生理学教研室

某些逆转录病毒(retrovirus)带有使细胞癌变的DNA序列,即为病毒的癌基因(v-oncogen或v-onc)。病毒癌基因与粒子病毒无关,不影响病毒复制,却与正常细胞的DNA序列同源,故可看作病毒的寄生物。目前已从诱生动物肿瘤的逆转录病毒中分离得十... 详细信息

某些逆转录病毒(retrovirus)带有使细胞癌变的DNA序列,即为病毒的癌基因(v-oncogen或v-onc)。病毒癌基因与粒子病毒无关,不影响病毒复制,却与正常细胞的DNA序列同源,故可看作病毒的寄生物。目前已从诱生动物肿瘤的逆转录病毒中分离得十几种癌基因,以分离得的动物及所诱生肿瘤名称而命名。如大鼠Harvey肉瘤病毒的癌基因(V—Ha—ras)等。以病毒癌基因互补DNA(cDNA)为探针,使用DNA杂交及转染等技术,证实脊椎动物以至人类正常细胞的DNA中皆有

关键词：病毒癌基因 DNA 正常细胞 NIH oncogenes 染色体易位横纹肌肉瘤肿瘤细胞细胞癌变逆转录病毒膀胧癌细胞转化 RSV 淋巴细胞白血病动物肿瘤肿瘤发生等位基因细胞株淋巴瘤肉瘤病毒

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癌基因(oncogenes)·续·

肿瘤防治研究 1985年第4期 197-201页

作者：杨焕明高翼之王世浚南京铁道医学院

三、不同onc的协同作用 1983年onc研究的最重大进展,可以说是证明了正常细胞的完全恶变至少需要两个以上的不同onc的协同作用。 1.协同作用的实验依据 Land等以激活的人c-ras~H-1或c-myc、

关键词：序列 EIA IT 产物激酶活性酪氨酸 EGF 正常细胞无限增殖互补群 oncogenes

PDRG1 at the interface between intermediary metabolism and oncogenesis

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World Journal of Biological Chemistry 2017年第4期8卷 175-186页

作者： Maríaángeles Pajares Department of Chemical and Physical Biology Centro de Investigaciones Biológicas(CSIC)Madrid 28040Spain Instituto de Investigación Sanitaria La Paz(IdiPAZ) Madrid 28046Spain

PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.

关键词： Epigenetic modifications Glutathione Methylation oncogenes Intermediary metabolism p53 and DNA damage-regulated gene 1 Protein complexes R2TP/prefoldin complex S-adenosylmethionine synthesis Redox stress