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Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma

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Genes & Diseases 2024年第3期11卷 47-50页

作者： Yuyuan Zhang Ziyang Zu Hui Xu Siyuan Weng Yuqing Ren Quan Cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan450052China Interventional Institute of Zhengzhou University ZhengzhouHenan450052China Interventional Treatment and Clinical Research Center of Henan Province ZhengzhouHenan 450052China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan450052China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor *** phenomenon can facilitate a better understanding of the mechanism and evolution of tumors and serve as a biological marker for diagnosing,classifying,and treating tumors.1 However,the nature of alteration occurrence and the impact on pancreatic adenocarcinoma(PAAD)remain *** SELECT algorithm was originally designed to systematically assess the evolutionary dependencies and their impact between altered genes in cancer for anticipating drug resistance and proposing alternative ***,to better characterize the etiology of PAAD and develop an improved risk assessment strategy,2 by utilizing SELECT,we identified a co-altered pathway subgroup of PAAD that demonstrated an elevated risk for unfavorable prognosis,a propensity for liver metastasis,and an immunologically cold microenvironment.

关键词： adenocarcinoma elevated alteration

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Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy

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Genes & Diseases 2024年第1期11卷 1-3页

作者： Kaiyan Chen Ying Yu Zhiyu Huang Lei Gong Yun Fan The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) HangzhouZhejiang 310022China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesHangzhouZhejiang 310022China Department of Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310022China Department of Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

With morphological features resembling hepatocellular carcinoma,hepatoid adenocarcinoma of the lung(HAL)is a rare and aggressive subtype of lung cancer with a 5-year survival of only 8%.1 Most HAL patients present increased serum alpha-fetoprotein(AFP)levels that are commonly related to poor *** insights into HAL have come from case series or reports,and TP53 is frequently mutated in *** heterogeneity of HAL complicates the *** no established standard,the management of HAL is modeled on that of classical lung adenocarcinoma,although with dismal outcomes.2 Herein,we reported the effective management of a stage IIIb HAL patient with perioperative chemoimmunotherapy and curative-intent *** patient remained disease-free and minimal residual disease(MRD)-negative for more than one year after surgery.

关键词： adenocarcinoma patient lung

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Concurrent occurrence of adenocarcinoma and urothelial carcinoma of the prostate gland:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5952-5959页

作者： Jhe Yuan Hsu Yi Sheng Lin Li Hua Huang Tang Yi Tsao Chao Yu Hsu Yen Chuan Ou Min Che Tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan Department of Pathology Tungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan

BACKGROUND adenocarcinoma is the most common subtype of prostate *** urothelial carcinoma(UC)typically originates from the prostatic *** concurrent occurrence of adenocarcinoma and UC of the prostate gland is *** SUMMARY We present the case of an 82-year-old male patient with simultaneous adenocarcinoma and UC of the prostate *** patient underwent a transrectal ultrasound-guided biopsy,and the pathology test revealed ***,transurethral laser prostatectomy was performed,and the pathology test indicated adenocarcinoma of the prostate with a Gleason score of 3+4 and highgrade ***,the patient was treated with androgen deprivation therapy,systemic chemotherapy,and *** resonance imaging performed during follow-up revealed a prostate tumor classified as cT2cN1M0,stage ***,the patient underwent robotic-assisted radical prostatectomy and bilateral pelvic lymph node *** final pathology test of the prostate gland revealed acinar-type adenocarcinoma,Gleason pattern 4+3,pT2N0M0,and high-grade *** patient regularly presented to the clinic for postoperative follow-up *** did not experience any urinary *** According to our literature review,this is the first reported case of coexisting adenocarcinoma and UC of the prostate gland.

关键词： adenocarcinoma Urothelial carcinoma Prostate Coexist Case report

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Epidemiology of EGFR Mutation in adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain Kumar Prabhash Venkatraman Radhakrishnan Shashank Srinivasan Pfizer Products India Private Limited Mumbai India Tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.

关键词： Epidemiology Epidermal Growth Factor Receptor adenocarcinoma Non-Small Cell Lung Cancer India

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Clinical analysis of lung adenocarcinoma with epidermal growth factor receptor mutation transformed into sarcoma

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 99-99页

作者：祝清清 Dept Respir&Critical Care Med 1st Affil HospSoochow UnivSuzhou 215006

Objective To analyze the clinical data of a case of lung adenocarcinoma with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)resistance transforming into sarcoma,and to conduct a literature review to improve the understanding of the resistance *** transformation is a unique form of acquired resistance of EGFR-TKIs in non-small cell lung cancer (NSCLC).

关键词： sarcoma adenocarcinoma lung

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Computed tomography-based nomogram of Siewert type Ⅱ/Ⅲ adenocarcinoma of esophagogastric junction to predict response to docetaxel, oxaliplatin and S-1

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World Journal of Radiology 2024年第1期16卷 9-19页

作者： Chuan-Qinyuan Zhou Dan Gao Yan Gui Ning-Pu Li Wen-Wen Guo Hai-Ying Zhou Rui Li Jing Chen Xiao-Ming Zhang Tian-Wu Chen Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Radiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Neoadjuvant chemotherapy(NAC)has become the standard care for advanced adenocarcinoma of esophagogastric junction(AEG),although a part of the patients cannot benefit from *** are no models based on baseline computed tomography(CT)to predict response of Siewert type II or III AEG to NAC with docetaxel,oxaliplatin and S-1(DOS).AIM To develop a CT-based nomogram to predict response of Siewert type II/III AEG to NAC with *** One hundred and twenty-eight consecutive patients with confirmed Siewert type II/III AEG underwent CT before and after three cycles of NAC with DOS,and were randomly and consecutively assigned to the training cohort(TC)(n=94)and the validation cohort(VC)(n=34).Therapeutic effect was assessed by disease-control rate and progressive disease according to the Response Evaluation Criteria in Solid Tumors(version 1.1)*** prognostic factors associated with responses after DOS treatment including Siewert classification,gross tumor volume(GTV),and cT and cN stages were evaluated using pretherapeutic CT data in addition to sex and *** and multivariate analyses of CT and clinical features in the TC were performed to determine independent factors associated with response to DOS.A nomogram was established based on independent factors to predict the *** predictive performance of the nomogram was evaluated by Concordance index(C-index),calibration and receiver operating characteristics curve in the TC and *** Univariate analysis showed that Siewert type(52/55 vs 29/39,P=0.005),pretherapeutic cT stage(57/62 vs 24/32,P=0.028),GTV(47.3±27.4 vs 73.2±54.3,P=0.040)were significantly associated with response to DOS in the *** analysis of the TC also showed that the pretherapeutic cT stage,GTV and Siewert type were independent predictive factors related to response to DOS(odds ratio=4.631,1.027 and 7.639,respectively;all P<0.05).The nomogram developed with these independent factors showed an exc

关键词： Esophagogastric junction adenocarcinoma Neoadjuvant chemotherapy Response Tomography,X-ray computed Predictor

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Prognostic value of the RNA editing enzyme: ADAR1, and its association with immune cells infiltration in pancreatic adenocarcinoma

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Genes & Diseases 2023年第1期10卷 41-44页

作者： Jialong Qi You Zhou Zhikai Zhu Chuanshan Xu Wenjie Chen Key Laboratory of Molecular Target&Clinical Pharmacology and the State&NMPA Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People's Hospital of Yunnan ProvinceKunming 650032China Beijing Tiantan Hospital Capital Medical UniversityBeijing 100070China State Key Laboratory of Respiratory Disease Guangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious DiseaseGuangzhouGuangdong 510182China Sydney Vital Translational Cancer Research Centre Westbourne StNSW 2065Australia

The adenosine deaminase acting on RNA(ADAR)protein family was well characterized as RNA editing enzymes converting adenosines to inosines(A-to-l)in dsRNA *** share a homologous structure including the dsRNA-binding domain and the deaminase ***1 function as the primary editing enzyme for A-to-l mutation because of its higher and ubiquitous expression compared to ADAR2 and ADAR3 in eukaryotes.

关键词： ADAR1 adenocarcinoma editing

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Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5134-5135页

作者： Yuan Gao Liqing Yu Hongming Miao Department of Pathophysiology College of High Altitude Military MedicineArmy Medical UniversityChongqing400038China Division of Endocrinology Diabetesand NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMDUSA Jinfeng Laboratory Chongqing401329China

Recently,Piper and Hoen et *** a new immunotherapy for pancreatic cancer in orthotopic pancreatic ductal adenocarcinoma(PDAC)KPC tumor model.1 They found that a murine PD-1-targeted IL-2 variant complex(PD1-IL2v),in combination with radiation therapy(RT),can inhibit PDAC growth and metastasis by immune system,and induce a lasting immunological memory response to the tumor.

关键词： PD1 adenocarcinoma

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Contributions and prognostic performances of m7G RNA regulators in pancreatic adenocarcinoma

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Chinese Medical Journal 2022年第17期135卷 2101-2103页

作者： Qihang Yuan Jie Ren Xu Chen Yantong Dong Dong Shang Department of General Surgery The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Clinical Laboratory of Integrative Medicine The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Oncology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China

Pancreatic adenocarcinoma(PAAD)is the primary cause of mortalityfrom endocrine cancerglobaly,bringing a burden to public *** evidence has suggested that the formation of PAAD is an extremely complicated biological pro... 详细信息

关键词： adenocarcinoma mortality evolution

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Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy

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World Journal of Gastroenterology 2023年第20期29卷 3145-3156页

作者： Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki Yuto Shimamura Haruo Ikeda Yohei Nishikawa Manabu Onimaru Kai Matsuo Masayuki Isozaki William Yang Kenji Issha Satoshi Kimura Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Digestive Disease Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan JSR Corporation Tokyo 105-0021Japan Bay Spec Inc. San JoseCA 95131United States Fuji Technical Research Inc. Yokohama 220-6215Japan Department of Laboratory Medicine and Central Clinical Laboratory Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Hematology Saitama Cancer CenterInamachi 362-0806Japan Department of Pathology Showa University Koto Toyosu HospitalTokyo 135-8577Japan

BACKGROUND Cancer detection is a global research focus,and novel,rapid,and label-free techniques are being developed for routine clinical *** has led to the development of new tools and techniques from the bench side to routine clinical *** this study,we present a method that uses Raman spectroscopy(RS)to detect cancer in unstained formalin-fixed,resected specimens of the esophagus and *** method can record a clear Raman-scattered light spectrum in these specimens,confirming that the Raman-scattered light spectrum changes because of the histological differences in the mucosal *** To evaluate the use of Raman-scattered light spectrum for detecting endoscopically resected specimens of esophageal squamous cell carcinoma(SCC)and gastric adenocarcinoma(AC).METHODS We created a Raman device that is suitable for observing living tissues,and attempted to acquire Raman-scattered light spectra in endoscopically resected specimens of six esophageal tissues and 12 gastric *** evaluated formalin-fixed tissues using this technique and captured shifts at multiple locations based on feasibility,ranging from six to 19 locations 200 microns apart in the vertical and horizontal ***,a correlation between the obtained Raman scattered light spectra and histopathological diagnosis was *** We successfully obtained Raman scattered light spectra from all six esophageal and 12 gastric *** data capture,the tissue specimens were sent for histopathological analysis for further processing because RS is a label-free methodology that does not cause tissue destruction or *** on data analysis of molecular-level substrates,we established cut-off values for the diagnosis of esophageal SCC and gastric *** analyzing specific Raman shifts,we developed an algorithm to identify the range of esophageal SCC and gastric AC with an accuracy close to that of histopathological *** Our technique pr

关键词： Raman spectroscopy Squamous cell carcinoma adenocarcinoma Esophagus Stomach Labelfree cancer detection Real-time diagnosis

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