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In vitro bench testing using patient-specific 3D models for percutaneous pulmonary valve implantation with Venus P-valve

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Chinese Medical Journal 2024年第8期137卷 990-996页

作者： Yu han.Zehua shao Zirui sun Yan han.Hongdang Xu shubo song Xiangbin Pan peter P.T.de Jaegere Taibing Fan Gejun Zhan. Department of structure Heart Disease Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Children’s Heart Center Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Department of Anesthesiology Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Department of structure Heart Disease Fuwai Hospital Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Erasmus MCRotterdam 3015 GDNetherlands

Background:Due to the wide variety of morphology,size,and dynamics,selecting an optimal valve size and location poses great difficulty in percutaneous pulmonary valve implantation(PPVI).This study aimed to report our experience with in vitro bench testing using patient-specific three-dimensional(3D)-printed models for planning PPVI with the Venus ***:Patient-specific 3D soft models were generated using PolyJet printing with a compliant synthetic material in 15 patients scheduled to undergo PPVI between July 2018 and July 2020 in Central China Fuwai Hospital of Zhengzhou ***:3D model bench testing altered treatment strategy in all patients(100%).One patient was referred for surgery because testing revealed that even the largest Venus P-valve would not anchor *** the remaining 14 patients,valve size and/or implantation location was altered to avoid valve migration and/or compression coronary *** four patients,it was decided to chan.e the point anchoring because of inverted cone-shaped right ventricular outflow tract(RVOT)(n=2)or risk of compression coronary artery(n=2).Concerning sizing,we found that an oversize of 2-5 mm *** of the valve was dictated by the flaring of the in-and outflow portion in the pulmonary *** was successful in all 14 patients(absence of valve migration,no coronary compression,and none-to-mild residual pulmonary regurgitation[PR]).The diameter of the Venus P-valve in the 3D simulation group was significantly smaller than.that of the conventional planning group(36[2]vs.32[4],Z=-3.77,Psions:In vitro testing indicated no need to oversize the Venus P-valve to the degree recommended by the balloon-sizing technique,as 2-5 mm sufficed.

关键词： Heart valve prosthesis implantation Percutaneous pulmonary valve intervention Pulmonary regurgitation bench testing 3D printing Venus P-valve

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Engineered plant extracellular vesicles for autoimmune diseases therapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina han.Yan Wu Yafei han.Xiangfei Liu han.Liu Jiacan su Institute of Translational Medicine Shanghai UniversityShanghai 200444China Organoid Research Center Shanghai UniversityShanghai 200444China National Center for Translational Medicine(shan.hai)sHU Branch Shanghai UniversityShanghai 200444China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy *** extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive *** to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechan.sms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in ***,we propose engineering approaches and administration methods for ***,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of *** gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for *** and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

关键词： autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification

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Neural dynamics for improving optimiser in deep learning with noise considered

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 722-737页

作者： Dan su Predrag s.stanimirović Ling Bo han.Long Jin school of Information science and Engineering Lanzhou UniversityLanzhouChina Faculty of sciences and Mathematics University of NišNišSerbia school of Electronics and Information Engineering Guangdong Ocean UniversityZhanjiangChina

As deep learning evolves,neural network structures become increasingly sophisticated,bringing a series of new optimisation *** example,deep neural networks(DNNs)are vulnerable to a variety of *** neural networks under privacy constraints is a method to alleviate privacy leakage,and one way to do this is to add noise to the ***,the existing optimisers suffer from weak convergence in the presence of increased noise during training,which leads to a low robustness of the *** stabilise and improve the convergence of DNNs,the authors propose a neural dynamics(ND)optimiser,which is inspired by the zeroing neural dynamics originated from zeroing neural *** authors first analyse the relationship be-tween DNNs and control ***,the authors construct the ND optimiser to update network ***,the proposed ND optimiser alleviates the non-convergence problem that may be suffered by adding noise to the gradient from different ***,experiments are conducted on different neural network structures,including ResNet18,ResNet34,Inception-v3,MobileNet,and long and short-term memory *** results using CIFAR,YouTube Faces,and R8 datasets demonstrate that the ND optimiser improves the accuracy and stability of DNNs under noise-free and noise-polluted *** source code is publicly available at https://***/LongJin-lab/ND.

关键词： deep learning deep neural networks

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From Liquid to solid‑state Lithium Metal Batteries:Fundamental Issues and Recent Developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： Zhao Zhan. Wei‑Qiang han school of Materials science and Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density *** metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density *** this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in ***,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these *** utilization of solid-state electrolytes can significantly enhan.e the safety of LMBs and represents the only viable approach for advancing *** review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid *** noteworthy is that the introduction of ssEs will exacerbate differences in electrochemical and mechan.cal properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal *** on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite solid electrolyte Interface

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Inbreeding and genetic load in a pair of sibling grouse species:Tetrastes sewersowi and ***

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Avian Research 2024年第2期15卷 265-270页

作者： Kai song Tom van der Valk Bin Gao peter Halvarsson Yun Fang Wendong Xie siegfried Klaus Zhiming han.Yue-Hua sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular Biology Uppsala75273Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5 JenaD-07749Germany The state Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(Tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).These levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-Tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels than.Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.

关键词： Genetic load Inbreeding Purifying selection Qinghai-Tibetan Plateau ROH Tetrastes

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Four Late-type Galaxies with Double Radio Lobes and Properties of such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.s.Yuan X.Y.Gao Z.L.Wen J.L.han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAs Key Laboratory of FAsT National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China school of Astronomy and space sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechan.sm for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released Dark Energy spectroscopic Instrument imaging surveys and the radio sources from the NRAO VLA sky survey and the Faint Images of the Radio sky at Twenty-centimeter,we identify four Late-type Galaxies with double Radio Lobes(La GRLs):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previously known La GRLs,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)La GRLs belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of La GRLs are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

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Prediction and Output Estimation of Pattern Moving in Non-Newtonian Mechan.cal systems Based on Probability Density Evolution

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Computer Modeling in Engineering & sciences 2024年第4期139卷 515-536页

作者： Cheng han.Zhengguang Xu school of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Knowledge Automation for Industrial Processes University of Science and Technology BeijingBeijing100083China

A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechan.cal systems,assuming that the system satisfies the generalized Lipschitz *** a complex nonlinear system primarily governed by statistical laws rather than.Newtonian mechan.cs,the output of non-Newtonian mechan.cs systems is difficult to describe through deterministic variables such as state variables,which poses difficulties in predicting and estimating the system’s *** this article,the temporal variation of the system is described by constructing pattern category variables,which are non-deterministic *** pattern category variables have statistical attributes but not operational attributes,operational attributes are assigned to them by posterior probability density,and a method for analyzing their motion laws using probability density evolution is ***,a data-driven form of pattern motion probabilistic density evolution prediction method is designed by combining pseudo partial derivative(PPD),achieving prediction of the probability density satisfying the system’s output *** on this,the final prediction estimation of the system’s output value is realized by minimum variance unbiased ***,a corresponding PPD estimation algorithm is designed using an extended state observer(EsO)to estimate the parameters to be estimated in the proposed prediction *** effectiveness of the parameter estimation algorithm and prediction method is demonstrated through theoretical analysis,and the accuracy of the algorithm is verified by two numerical simulation examples.

关键词： Non-newtonian mechan.cal systems prediction and estimation pattern moving probability density evolution pseudo partial derivative

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Analyses on an electronic voltage transformer's failure by its resonance with very fast transient overvoltage and suppression

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High Voltage 2024年第1期9卷 150-162页

作者： Ruoyu han.Houda Zhu Qing Chen Hongbin Li Yue Tong Linshan.han.Yang Jiao school of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhanChina China Electric Power Research Institute WuhanChina school of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanChina

As voltage measuring devices are widely used in the high voltage power system with a primary-secondary-fusion structure,electronic voltage transformers are directly connected to the primary conductor and would face much more serious electromagnetic environments than.general secondary *** a result,they would still experience failures even when general protection measures are adopted to suppress overvoltages'*** address this issue,an innovative method is proposed after analyses are conducted on the resonance between a transformer and an *** this method,an air-cored coil is installed in a transformer to artificially shift its natural frequency and to dodge the high-frequency dominant component of a transient overvoltage,avoiding the aforementioned resonance and suppressing the secondary *** addition,simulations and laboratory tests are conducted to prove this method's validity.

关键词： transient resonance mentioned

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Critical layer in liquid-solid system influencing the remediation of chromium using zeolite-supported sulfide nano zero-valent iron

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Journal of Environmental sciences 2024年第1期135卷 232-241页

作者： Chundi Zhou Caiyun han.Nengsheng Liu Faculty of Material and Environment Guangxi University for NationalitiesNanning 530008China College of Environmental science and Engineering Tongji UniversityShanghai 200092China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

sulfidated nano zero-valent iron particles were immobilized on ZsM-5 zeolite(Z/s-nZⅥ)and used for hexavalent chromium(Cr(Ⅵ))*** performance of Z/s-nZⅥimproved with the increase in Cr(Ⅵ)concentration(significantly decreased for a Cr(Ⅵ)concentration of more than.60 mg/*** adsorption behavior for Cr(Ⅵ)was different from that reported in previous *** improved performance can be tailored for increasing efficiency of nano zero-valent iron(nZⅥ)corrosion,while the degree of corrosion of nZⅥwas affected by the concentration of the pollutant as discussed by kinetics,X-ray diffraction(XRD)and X-ray photoelectron spectrometer(XPs)*** experiments for the dissolution of ferrous ions and the dosage of adsorbent demonstrated that the critical layer in the liquid-solid system chan.ed with the increase in the concentration of Cr(Ⅵ)(Cr(Ⅵ):Z/s-nZⅥ>0.6).Moreover,the removal mechan.sms of Cr(Ⅵ)were elucidated through XRD,transmission electron microscopy(TEM)and XPs *** results demonstrate that the species of chromium in the critical layer chan.ed from Cr(Ⅲ)to Cr(Ⅵ)as the concentration of chromium increased from low to ***,the critical layer was composed of Cr(Ⅵ),Fe(Ⅱ),O and H ***,the experiments of coexisting ions and aging time confirmed that Z/s-nZⅥpossessed high selectivity and stability to ensure efficiency and cost-effectiveness in practical applications.

关键词： Cr(VI) Corrosion Critical layer selectivity stability

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Two-Dimensional Materials for Highly Efficient and stable Perovskite solar Cells

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Nano-Micro Letters 2024年第10期16卷 176-212页

作者： Xiangqian shen Xuesong Lin Yong Peng Yiqiang Zhan. Fei Long Qifeng han.Yanbo Wang Liyuan han state Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People's Republic of China Xinjiang Key Laboratory of solid state Physics and Devices School of Physical Science and TechnologyXinjiang UniversityUrumqi 830046People's Republic of China special Division of Environmental and Energy science College of Arts and SciencesKomaba Organization for Educational ExcellenceUniversity of TokyoTokyo 153-8902Japan state Key Laboratory of Advanced Technology for Materials synthesis and Processing Wuhan University of TechnologyWuhan 430070People's Republic of China College of Chemistry Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001People's Republic of China Guangxi Key Laboratory of Optical and Electronic Materials and Devices Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of ResourcesSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People's Republic of China

Perovskite solar cells(PsCs)offer low costs and high power conversion ***,the lack of long-term stability,primarily stemming from the interfacial defects and the sus-ceptible metal electrodes,hinders their practical *** the past few years,two-dimensional(2D)materials(e.g.,graphene and its derivatives,transitional metal dichalcogenides,MXenes,and black phosphorus)have been identified as a promising solution to solving these problems because of their dangling bond-free surfaces,layer-dependent electronic band structures,tunable functional groups,and inherent ***,recent progress of 2D material toward efficient and stable PsCs is summarized,including its role as both interface materials and *** discuss their beneficial effects on perovskite growth,energy level alignment,defect passivation,as well as blocking external *** particular,the unique properties of 2D materials to form van der Waals heterojunction at the bottom interface are ***,perspectives on the further development of PsCs using 2D materials are provided,such as designing high-quality van der Waals heterojunction,enhan.ing the uniformity and coverage of 2D nanosheets,and developing new 2D materials-based electrodes.

关键词： Perovskite solar cells Two-dimensional materials Interface engineering Van der Waals heterojunction Electrodes

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