Inbreeding and genetic load in a pair of sibling grouse species:Tetrastes sewersowi and ***

作     者：Kai Song Tom van der Valk Bin Gao Peter Halvarsson Yun Fang Wendong Xie Siegfried Klaus Zhiming Han Yue-Hua Sun Jacob Hoglund Kai Song;Tom van der Valk;Bin Gao;Peter Halvarsson;Yun Fang;Wendong Xie;Siegfried Klaus;Zhiming Han;Yue-Hua Sun;Jacob Höglund

作者机构：Key Laboratory of Animal Ecology and Conservation BiologyInstitute of ZoologyChinese Academy of SciencesBeijing100101China Animal EcologyDepartment of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular BiologyUppsala75273Sweden Unit of ParasitologyDepartment of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5JenaD-07749Germany The State Key Laboratory of Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing100101China 

出 版 物：《Avian Research》 (鸟类学研究（英文版）)

年 卷 期：2024年第15卷第2期

页      面：265-270页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 090501[农学-动物遗传育种与繁殖] 

基　　金：funded by the National Natural Science Foundation of China(NSFC,Grant No.31520103903 to Y.-H.Sun and J.Hoglund) the Biodiversity Conservation Project of the Second Forest and Grass Ecosystem Recovery(Grant No.QHTX-2021-016) 

主　　题：Genetic load Inbreeding Purifying selection Qinghai-Tibetan Plateau ROH Tetrastes 

摘      要：Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(Tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from Sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).These levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-Tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels than Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.