检索结果-南通市图书馆

An Improved and Convenient Procedure for the Synthesis of Ozagrel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第2期17卷 180-182页

作者： Chun guo xiao Dan liu Zhen Gang XIE Chu Jun LI School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016

A novel approach to the synthesis of ozagrel is described. The target compound is conveniently prepared from the commercially available material, 1,1-carboxyldiimidazole （CDI） through the condensation and hydrolyzat... 详细信息

关键词： Ozagrel synthesis 1 1-carboxyldiimidazole.

Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第11期18卷 1257-1261页

作者： Yuan Hu Li-Hua He Di xiao guo-Dong liu Yi-Xin Gu xiao-Xia Tao Jian-Zhong Zhang State Key Laboratory forInfectious Disease Prevention and Control National Institute forCommunicable Disease Control and Prevention Chinese Centerfor Disease Control and Prevention Beiiing 102206 China

AIM： To investigate the non-He/icobacterpy/ori （H. pylori） bacterial flora concurrent with H. pylori infection.METHODS： A total of 103 gastric biopsy specimens from H. pylori positive patients were selected for bacterial culture. All the non-H, pylori bacterial isolates were identified by matrix assisted laser desorption ionization time-of-flight mass spectrometry （MALDI-TOF MS）.RESULTS： A total of 201 non-H, pyiori bacterial isolates were cultivated from 67 （65.0%） of the 103 gastric samples, including 153 isolates identified successfully at species level and 48 at genus level by MALDI-TOF MS. The dominant species were Streptococcus, Neisseria, Rothla and Staphylococcus, which differed fromthe predominantly acid resistant species reported previously in healthy volunteers. The prevalence of non-H. pylori bacteria was higher in non-ulcer dyspepsia group than in gastric ulcer group （100% vs 42.9%, P 〈 0.001）. Six bacterial species with urease activity （Staphylococcus epidermidis, Staphylococcus warneri, Staphylococcus capitis, Staphylococcus aureus, Brevibacteriurn spp. and Klebsiella pneumoniae） were also isolated.CONCLUSION： There is a high prevalence of the non-H, pylori bacteria concurrent with H. pylori infection, and the non-H, pylori bacteria may also play important as-yet-undiscovered roles in the pathogenesis of stomach disorders.

关键词： Non-Helicobacter pylori', Bacterial flora Gastrointestinal diseases Matrix-assisted laser desorp-tion ionization time-of-flight mass spectrometry

Primary Organicamine Templated Indium Iodate (H_2en)KIn(IO_3)_6·2(H_2O) with Hydrogen-bonded Helices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第1期26卷 1-4页

作者： liu guo-zong liu xiao-min DING Hong NING De-kuan LI Guang-hua SHI Zhan FENG Shou-hua State Key Laboratory of lnorganie Synthesis ＆ Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

The first primary organicamine templated indium iodate with the formula （H2en）KIn（IO3）6-2（H2O） was hydrothermally synthesized via reaction at 100 ℃ for 7 d and characterized by single-crystal X-ray diffraction and thermal analysis. The compound crystallized in a triclinic system with space group P1, a=0.69803（14） nm, b=0.70863（14） nm, c=1.2091（2） nm, a=76.417（4）°,β=79.953（4）°, γ=72.206（3）°, V=0.55012（19） nm3. Structure determination indicates that it is made up of zero-dimensional units each of which consists of [In（IO3）6]3 anion, potassium, water and ethylenediamine cation. The most striking feature of the compound is that it possesses helical hydrogen bonds formed by organic amine template, water molecules and inorganic network.

关键词： Hydrothermal synthesis Indium iodate Helical hydrogen bond Crystal structure

Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第10期23卷 1836-1842页

作者： Hong-Zhi Shi Yu-Ning Wang xiao-Hui Huang Ke-Cheng Zhang Hong-Qing Xi Jian-Xin Cui guo-xiao liu Wen-Tao Liang Bo Wei Lin Chen Department of General Surgery Chinese PLA General Hospital Department of General Surgery General Hospital of Armed Police Force Department of Surgery Chinese PLA General Hospital Institute of General Surgery Chinese PLA General Hospital

AIM To investigate the association between serum human epidermal growth factor receptor 2(HER2) extracellular domain(ECD) and tissue HER2 status, and the prognostic value of serum HER2 ECD in patients with gastric *** A total of 239 patients with gastric cancer were enrolled from December 2012 to June 2013. Serum HER2 ECD was determined by chemiluminescent assay, and tissue HER2 status was evaluated by immunohistochemistry and fluorescence in situ hybridization assay. A receiver operating characteristic(ROC) curve was plotted to identify the optimal cut-off value for serum HER2 ECD assay for predicting survival in gastric cancer *** Serum HER2 ECD was significantly correlated with tissue HER2 status(P < 0.001), tumor size(P < 0.001), and intestinal type of gastric cancer(P =0.021). Serum HER2 ECD levels differed significantly between patients with HER2-positive tissue expression and those with HER2-negative tissue expression. ROC analysis yielded an area under the curve value of 0.79(95%CI: 0.71-0.87, P < 0.001), with a sensitivity and specificity of 0.54(95%CI: 0.37-0.70) and 0.93(95%CI: 0.88-0.96), respectively. With a cut-off value of 24.75 ng/m L, high serum HER2 ECD had a negative impact on overall survival of the patients(HR: 1.93, 95%CI: 1.32-4.38, P = 0.006). CONCLUSION Serum HER2 ECD could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer. Optimal cut-off criteria for predicting survival should be established.

关键词： Gastric cancer Serum HER2 extracellular domain Tissue HER2 status Prognosis

Hybrid procedures for thoracoabdominal aortic aneurysms and dissections

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第4期126卷 620-625页

作者： ZHANG Hong-peng guo Wei liu xiao-ping JIA Xin XIONG Jiang MA xiao-hui Department of Vascular Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Hybrid procedures including debranching of visceral and renal arteries followed by endovascular exclusion of the thoracoabdominal aortic aneurysm （TAAA） have recently been proposed as a less invasive alternative to conventional TAAA surgery. This study aimed to evaluate the immediate and long-term outcomes of hybrid procedures for TAAA in high-risk patients. Methods Between September 1998 and May 2012, 32 high-risk TAAA patients （five females, median age 61.5 years） underwent hybrid procedures at a single institution. Simultaneous approach and staged approach were performed on the basis of patients＇ conditions. Follow-up computed tomography angiography （CTA） was routinely performed before discharge and at 6, 12 months and annually thereafter. Results Procedural success was achieved in all cases. The median hospital stay was （21.5＋2.3） days, and the median procedure time was （420＋31） minutes. Blood loss averaged （2100_＋261） ml. A total of 124 visceral artery bypasses was performed. Two patients （6.3%） died within 30 days. One patient exhibited complete paraplegia （3.1%）. The visceral graft patency was 96.1% at 3 years. All-cause survival rates were 93.8%, 87.5%, 81.3% and 53.1% at 1, 2, 3 and 5 years, respectively. No patient died due to aortic events. The freedom rates from aortic events were 96.9%, 93.6%, 87.5%, 68.8% at 1,2, 3 and 5 years, respectively. Conclusions The results of visceral hybrid repair for high-risk patients with complex TAAAs are encouraging. However, the procedure is still a significant physiological insult to patients. Until branched and fenestrated endovascular repair become more common, hybrid procedure will continue to have a role in high-risk patients.

关键词： hybrid procedure thoraeoabdominal aortic aneurysm endovascular aortic repair," dissection," stent-grafi

关于非线性系统两类广义混沌同步存在性的研究

在线全文

学校读者我要写书评

暂无评论

物理学报 2008年第10期57卷 6086-6092页

作者：过榴晓徐振源江南大学理学院信息与计算科学系

研究了非线性系统两类广义混沌同步的存在性.即在响应系统的修正方程在具有渐近稳定平衡点或渐近稳定周期轨道的情况下,满足一定的条件,可将广义同步化流形存在性问题转化为Lipschitz函数族的压缩不动点问题,理论上严格证明了该广义同... 详细信息

研究了非线性系统两类广义混沌同步的存在性.即在响应系统的修正方程在具有渐近稳定平衡点或渐近稳定周期轨道的情况下,满足一定的条件,可将广义同步化流形存在性问题转化为Lipschitz函数族的压缩不动点问题,理论上严格证明了该广义同步化流形的指数吸引性.数值仿真证实了理论的正确性及有效性.

关键词：广义同步化流形压缩不动点指数吸引性

Oxaliplatin-based combination chemotherapy is still effective for the treatment of recurrent and platinum-resistant epithelial ovarian cancer： results from a single center

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第23期126卷 4477-4482页

作者： ZHANG guo LI xiao-ping liu Bing-jie WANG Jian-liu WANG Shi-jun CUI Heng WEI Li-hui Department of Gynecology Peking University People's HospitalBeijing 100044 China

Background Combination paclitaxel and carboplatin is currently a first-line regimen for ovarian ***,many patients develop tumor recurrence or drug resistance to this *** study aims to investigate the effectiveness and safety of an oxaliplatin ＋ epirubicin ＋ ifosfamide regimen for the treatment of recurrent and drug-resistant epithelial ovarian *** A retrospective analysis of 73 patients with recurrent and drug-resistant ovarian cancer was performed; 38 cases of them received oxaliplatin ＋ epirubicin ＋ ifosfamide regimens （lAP group）,35 patients received non-oxaliplatinbased chemotherapy regimens （control group）.The therapeutic effects and side effects of the oxaliplatin ＋ epirubicin ＋ ifosfamide regimen were analyzed and ***-Meier survival curves and Cox proportional hazards regression were used to compare progression-free and overall survival between the two *** Of the 38 patients in the lAP group,14 patients （36.84％） achieved complete remission,12 （31.58％） achieved partial remission,2 （5.26％） achieved stable disease and 10 （26.32％） developed progressive *** overall effective rate （complete or partial remission） of the lAP regime was 68.42％.While,of the 35 patients in the control group,12 patients （34.29％） achieved complete remission,3 （8.57％） achieved partial remission,5 （14.29％） achieved stable disease and 15 （42.86％） developed progressive *** overall effective rate was 42.86％,which was lower than that in the lAP group （P=0.035,X2=4.836）.Progression-free survival was 9.5 months （0-64 months） in the lAP group vs.3 months （0-74 months） in the non-oxaliplatin group （P=0.014 by Kaplan-Meier survival curves; HR=-2.260; 95％C/1.117-4.573; P=0.023 by Cox proportional hazards regression）.Median overall survival was 46 months （9-124 months）in the lAP group vs.35 months （9-108 months） in non-oxaliplatin group （P=0.018 by Kaplan-Meier survival curves;HR=2.272; 95％CI 1.123-4.598; P=0.022 by Cox proportiona

关键词： ovarian cancer oxaliplatin drug-resistance recurrent

Effects of Medium on in Vitro Maturation of Pig Oocytes and in Vitro Early Development of Parthenogenetic Embryos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2011年第4期3卷 4-5,15页

作者： liu xiao-hui CAO Yang LANG Hong-yan JIN Hai-guo LUO xiao-tong liu Zheng WANG xiao-yang Animal Husbandry Branch Jilin Provincial Academy of Agricultural Sciences Gongzhuling 136100 China

[ Objective] To improve quality of oocytes maturing in vitro and to optimize in vitro culture system of porcine early embryos. [ Method ] Oocytes were cultured in the improved TCM199 and NCSU-23 basic media, which were added pig follicular fluid （PFF） or high-quality fetal bovine serum （FBS） both at a proportion of 10% （V/V）. After in vitro maturation and development, effects of medium on maturation of pig oocytes and development of eady parthenogenetic embryos were investigated using maturing rate of pig oocytes and development rate of parthenogenetic embryos as indicators. [ Result] After 42 h culture, the maturing rates of pig oocytes respectively cultured in the TCM199, TCM199 added FBS, TCM199 added PFF, NCSU-23, NCSU-23 added FBS and NCSU-23 added PFF were （54.2 ±3.5）%, （68.5 ±3.2）%, （69.3 ±3.7）%, （51.6 ±3.3）%, （63.2 ±3.1 ）% and （65.5 ±3.5）%, respectively. The pig oocytes cultured in the TCM199 or NCSU-23 that was added FBS or PFF had significantly higher maturing rate （P 〈 0.05）. The development rates of parthenogenetic embryos were not significantly different between these six experimental media. However, the parthenogenetic embryos which developed in the TCM199 added PFF （36.5 ±4.8） had significantly more blastomeres than those developed in the TCM199 or NCSU-23 （ 18.7 ± 3.2 and 15.5 ± 2.4, respectively）（ P 〈 0.05）. [ Conclusion ] The improved TCM199 and NCSU-23 added PFF or FBS can largely promote in vitro maturation of pig oocytes and in vitro development of early parthenogenetic embryos.

关键词： Pig Oocytes In vitro maturation In vitro development

Cesarean delivery on maternal request and childhood intelligence： a cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第23期124卷 3982-3987页

作者： LI Hong-tian YE Rong-wei PEI Li-jun REN Ai-guo ZHENG xiao-ying liu Jian-meng Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health Peking University Health Science Center Beijng 100191 China

Background Cesarean section births have been steadily increasing over the past decade and have become an epidemic in China. Cesarean delivery on maternal request is a major contributor to this upward trend, and there has been of much concern about its impact on maternal and child health. Most of mothers believe that cesarean delivery on maternal request can improve the child＇s intelligence, but direct evidence is sparse. In this cohort study, we aimed to directly assess the impact of cesarean delivery on maternal request on childhood intelligence. Methods Intelligence quotient （IQ） of 4144 preschool children from 21 cities/counties of Zhejiang and Jiangsu province whose mothers were registered in a population-based perinatal surveillance program during 1993-1996 was assessed with Chinese Wechsler Young Children Scale of Intelligence （C-WYCSI） in 2000. The outcomes were full-scale IQ, verbal IQ, and performance IQ of C-WYCSI. Mode of delivery and covariates were obtained from the surveillance program. We estimated unadjusted and adjusted effects of cesarean delivery on maternal request and assisted vaginal delivery on IQ scores compared with spontaneous vaginal delivery using regression analysis. Results The mean full-scale, verbal, and performance IQ for all children was 99.3_＋16.1,93.6_＋17.7, and 105.3_＋14.3. In crude analysis, cesarean delivery on maternal request versus spontaneous vaginal delivery was associated with an increase of 3.9 （95% confidence interval, 0.6 to 7.2） points in full-scale IQ, 4.8 （1.2 to 8.4） points in verbal IQ, and 2.4 （-0.6 to 5.3） points in performance IQ. After adjusting for maternal education, occupation, and IQ, the advantage was reduced to 1.6 （-1.3 to 4.5）, 2.3 （-0.8 to 5.5）, and 0.6 （-2.0 to 3.3） points for full-scale, verbal, and performance IQ, respectively. Assisted vaginal delivery versus spontaneous vaginal delivery was not associated with IQ scores in any analysis. Conclusion Neither cesarean delivery on maternal request nor

关键词： cesarean delivery on maternal request child intelligence quotient