Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis
Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis作者机构：Department of General SurgeryChinese People's Liberation Army General Hospital
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第9期
页 面：2605-2613页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Nature Science Foundation of China No.81101883
主 题：Periostin Cancer Tumorigenesis Extracellular matri
摘 要：The extracellular matrix component periostin is a secreted protein that functions as both a cell attachment protein and an autocrine or paracrine factor that signals through the cell adhesion molecule integrins αvβ3 and αvβ*** participates in normal physiological activities such as cardiac development,but is also involved in pathophysiological processes in vascular diseases,wound repair,bone formation,and tumor *** is of increasing interest in tumor biologybecause it is frequently overexpressed in a variety of epithelial carcinomas and is functionally involved in multiple steps of metastasis *** include the maintenance of stemness,niche formation,EMT,the survival of tumor cells,and angiogenesis,all of which are indispensable for gastric cancer *** has been reported to activate the PI-3K/AKT,Wnt,and FAK-mediated signaling pathways to promote ***,periostin represents a potentially promising candidate for the inhibition of *** this review article,we summarize recent advances in knowledge concerning periostin,its antagonist PNDA-3,and their influence on such key processes in cancer metastasis as maintenance of stemness,niche formation,epithelialto-mesenchymal transition,tumor cell survival,and *** particular,we focus our attention on the role of periostin in gastric cancer metastasis,speculate as to the usefulness of periostin as a therapeutic and diagnostic target for gastric cancer metastasis,and consider potential avenues for future research.
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