Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

作     者：Hong-Zhi Shi Yu-Ning Wang Xiao-Hui Huang Ke-Cheng Zhang Hong-Qing Xi Jian-Xin Cui Guo-Xiao Liu Wen-Tao Liang Bo Wei Lin Chen 

作者机构：Department of General SurgeryChinese PLA General Hospital Department of General SurgeryGeneral Hospital of Armed Police Force Department of SurgeryChinese PLA General Hospital Institute of General SurgeryChinese PLA General Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第10期

页      面：1836-1842页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China No.81272698 No.81672319 and No.81602507 

主　　题：Gastric cancer Serum HER2 extracellular domain Tissue HER2 status Prognosis 

摘      要：AIM To investigate the association between serum human epidermal growth factor receptor 2(HER2) extracellular domain(ECD) and tissue HER2 status, and the prognostic value of serum HER2 ECD in patients with gastric *** A total of 239 patients with gastric cancer were enrolled from December 2012 to June 2013. Serum HER2 ECD was determined by chemiluminescent assay, and tissue HER2 status was evaluated by immunohistochemistry and fluorescence in situ hybridization assay. A receiver operating characteristic(ROC) curve was plotted to identify the optimal cut-off value for serum HER2 ECD assay for predicting survival in gastric cancer *** Serum HER2 ECD was significantly correlated with tissue HER2 status(P 0.001), tumor size(P 0.001), and intestinal type of gastric cancer(P =0.021). Serum HER2 ECD levels differed significantly between patients with HER2-positive tissue expression and those with HER2-negative tissue expression. ROC analysis yielded an area under the curve value of 0.79(95%CI: 0.71-0.87, P 0.001), with a sensitivity and specificity of 0.54(95%CI: 0.37-0.70) and 0.93(95%CI: 0.88-0.96), respectively. With a cut-off value of 24.75 ng/m L, high serum HER2 ECD had a negative impact on overall survival of the patients(HR: 1.93, 95%CI: 1.32-4.38, P = 0.006). CONCLUSION Serum HER2 ECD could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer. Optimal cut-off criteria for predicting survival should be established.