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Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-geun lee H.H.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong lee You-Jin Jeon Min-Cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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Chronic gastrointestinal symptoms and quality of life in the Korean population

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World Journal of Gastroenterology 2008年第41期14卷 6388-6394页

作者： Jeong-Jo Jeong Myung-Gyu Choi Young-Seok Cho Seung-geun lee Jung-Hwan Oh Jae-Myung Park Yu-Kyung Cho In-Seok lee Sang-Woo Kim Sok-Won Han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine the Catholic University of Korea Department of Biostatistics University of North Carolina at Chapel Hill NC

AIM： To evaluate the prevalence of chronic gastroin- testinal symptoms and their impact on health-related quality of life （HRQOL） in the Korean population. METHODS： A cross-sectional survey, using a reliable and valid Rome I] based questionnaire, was per- formed on randomly selected residents, between 18 and 69 years in age. All respondents were interviewed at their homes or offices by a team of interviewers. The impact of chronic gastrointestinal symptoms on HRQOL was assessed using the Korean version of the 36-item Short-Form general health survey （SF-36）. RESULTS： Of the 1807 eligible subjects, 1417 （78.4%： male 762; female 655） were surveyed. Out of the respondents, 18.6% exhibited at least one chronic gastrointestinal symptom. The prevalence of gastro- esophageal reflux disease （GERD）, defined as heart- burn and/or acid regurgitation experienced at least weekly, was 3.5% （95% CI, 2.6-4.5）. The prevalence of uninvestigated dyspepsia, irritable bowel syndrome （IBS） and chronic constipation based on Rome Ⅱ criteria were 11.7% （95% CI, 10.1-13.5）, 2.2% （95% CI, 1.5-3.1）, and 2.6% （95% CI, 1.8-3.5） respectively. Compared with subjects without chronic gastrointesti- nal symptoms （n = 1153）, those with GERD （n = 50）, uninvestigated dyspepsia （n = 166） and IBS （n = 31） had significantly worse scores on most domains of the SF-36 scales. CONCLUSION： The prevalence of GERD, uninvesti- gated dyspepsia and IBS were 3.5%, 11.7% and 2.2% respectively, in the Korean population. The health- related quality of life was significantly impaired in subjects with GERD, uninvestigated dyspepsia and IBS in this community.

关键词： Chronic gastrointestinal symptom Gastroesophageal reflux disease Dyspepsia Irritable bowel syndrome Qaulibl of life

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Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

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Cellular & Molecular Immunology 2016年第6期13卷 862-870页

作者： Jeong-Min lee Young-Saeng Jang Bo-Ra Jin Sun-Jin Kim Hyeon-Jin Kim Bo-Eun Kwon Hyun-Jeong Ko Sung-il Yoon geun-Shik lee Woan-Sub Kim Goo-Young Seo Pyeung-Hyeun Kim Department of Molecular Bioscience School of Biomedical Science Kangwon National University Chuncheon Republic of Korea Laboratory of Microbiology and Immunology College of Pharmacy Kangwon National University Chuncheon Republic of Korea Department of Systems Immunology College of Biomedical Science Kangwon National University Chuncheon 200-701 Republic of Korea College of Veterinary Medicine Kangwon National University Chuncheon Gangwon 200-701 Republic of Korea Department of Animal Life and Environmental Science College of Agriculture and Life Science Hankyong National University Anseong-si 456-749 Republic of Korea

Lactoferrin （LF） and retinoic acid （RA） are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan （transforming growth factor-beta receptor III, TpRIII） and activation of canonical TGF-p signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line α （GLa） transcription and GLa promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced TβRIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 （CCR9） and a4β7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9＋ IgA＋ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses.

关键词： gut homing molecule IgA lactoferrin retinoic acid TGF-β receptor

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Effect of hydro co-extrusion on microstructure of duo-cast Al3003/Al4004 clad materials

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 75-80页

作者： In-Soo SON Sang-Pill lee Jin-Kyung lee Woo-Cheol KIM Ji-Seon MOON Sangmok lee Jong-Sup lee Yong-Bae KIM geun-Ahn lee Dong-Su BAE Department of Mechanical Engineering Dong-Eui University Busan Korea Department of Advanced Materials Engineering Dong-Eui University Busan Korea Advanced Forming Tech. Center Korea Institute of Industrial Technology Incheon Korea

The effects of hydro co-extrusion on the microstructure changes of aluminum hybrid duo-cast Al 3003/Al 4004 clad materials were studied. The specimen of duo-cast Al 3003/Al 4004 clad materials was in circle shape, and was composed of Al 3003(outside) and Al 4004(inside) materials. The specimen was extruded by the hydro co-extrusion equipment. The manufacturing conditions of the specimen were 423 K in temperature and 5 in extrusion ratio. The dimensions of the specimen were 80 mm in diameter of the Al 4004 material and 35 mm in thickness of the Al 3003 material before the hydro co-extrusion process, and 30 mm in diameter and about 5 mm in thickness after the extrusion process, respectively. The microstructure and the hardness for two specimens were investigated. The hardness value of cross section in the duo-cast Al 3003/Al 4004 clad materials before the extrusion process was increased in form of the parabola toward the center. However, after the extrusion process, it was almost constant in the portion of Al 4004 material. Lots of big voids above 1 mm in diameter in the specimen existed in the interfacing region of Al 3003 and Al 4004 materials before the extrusion process. These big voids disappeared after the process of hydro co-extrusion.

关键词： clad materials hydro co-extrusion process duo-casting microstructure

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New-onset diabetes after adult liver transplantation in the Korean Organ Transplantation Registry (KOTRY) study

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 425-439页

作者： Jong Man Kim Shin Hwang Kwang-Woong lee Jae-geun lee Je Ho Ryu Bong-Wan Kim Dong Lak Choi Young Kyoung You Dong-Sik Kim Yang Won Nah Koo Jeong Kang Jai Young Cho geun Hong In Seok Choi Hee Chul Yu Dongho Choi Myoung Soo Kim 无 Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Asan Medical CenterCollege of Medicine University of UlsanSouth Korea Department of Surgery Seoul National University College of MedicineSeoulSouth Korea Department of Surgery Yonsei University College of MedicineSeoulSouth Korea Department of Surgery Pusan National University College of MedicineBusanSouth Korea Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of MedicineSuwonSouth Korea Department of Surgery Catholic University of Daegu College of MedicineDaeguSouth Korea Department of Surgery College of MedicineCatholic University of KoreaSeoulSouth Korea Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulSouth Korea Department of Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea Department of Surgery Keimyung University School of MedicineDaeguSouth Korea Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSungnamSouth Korea Department of Surgery Ewha Woman’s University School of MedicineSeoulSouth Korea Department of Surgery Konyang University HospitalDaejonSouth Korea Department of Surgery Chonbuk National University School of MedicineJeonjuSouth Korea Department of Surgery Hanyang University College of MedicineSeoulSouth Korea The Korean Organ Transplantation Registry Study Group

Background:New-onset diabetes after transplantation(NODAT)is a serious complication following liver transplantation(LT).The present study aimed to investigate the incidence of and risk factors for NODAT using the Korean Organ Transplantation Registry(KOTRY)***:Patients with history of pediatric transplantation(age≤18 years),re-transplantation,multi-organ transplantation,or pre-existing diabetes mellitus were excluded.A total of 1,919 non-diabetic adult patients who underwent a primary LT between May 2014 and December 2017 were *** factors were identified using Cox regression ***:NODAT occurred in 19.7%(n=377)of adult liver transplant *** analysis showed steroid use,increased age,and high body mass index(BMI)in recipients,and implantation of a left-side liver graft was closely associated with NODAT in adult *** living donor liver transplant(LDLT)patients(n=1,473),open donor hepatectomy in the living donors,steroid use,small for size liver graft(graft to recipient weight ratio≤0.8),increased age,and high BMI in the recipient were predictive factors for *** use of antimetabolite and basiliximab induction reduced the incidence of NODAT in adult LT and in adult ***:Basiliximab induction,early steroid withdrawal,and antimetabolite therapy may prevent NODAT after adult *** BMI or advanced age in liver recipients,open donor hepatectomy in living donors,and small size liver graft can predict the occurrence of NODAT after adult LT or LDLT.

关键词： Diabetes living donors immunosuppression Asia

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Analysis of UV Laser Machining Process for High Density Embedded IC Substrates

Analysis of UV Laser Machining Process for High Density Embe...

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2012 International Conference on Manufacturing(Manufacturing 2012)

作者： Sung-Jun Park Jung-Han Song geun-an lee Dept. of Mechanical Engineering Korea National University of Transportation Advanced Convergent Technology R&D Group KITECH Metal Technology R&D Group KITECH

New manufacturing process capable of high density patterns has been required. The most popular technique used today to form such fine pitch conductors is Semi-Additive Process（SAP） or variations of semi-additive process. New manufacturing method focus on the technologies designed to produce a smooth interface between resin and copper conductors for advantages in the high frequency application and fine conductor pitch capabilities. In this study, laser microprocessing was investigated for resin materials with various filler size, and was selected by suitable materials with processability and physical characteristics.

关键词： Build-up film Laser processing Embedded pattern

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Enrichment of flavonoid aglycones in licorice extract enhanced anti-inflammatory potential,but its hypnotic effect was not altered

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中国药理学与毒理学杂志 2018年第4期32卷 337-338页

作者： Xue-qiong ZHANG Jin Hwa KIM Su-ying CUI Jun Tae BAE Xiang-yu CUI geun Soo lee Hyeong Bae PYO Yong-he ZHANG Department of Pharmacology Peking University School of Basic Medical Sciences Beijing 100191 China R&D Center Hanbul Cosmetics Co. Ltd. 62 Daeseong-ro 547 beon-gil Samseong-myeon Eumseong-gun Chungcheongbuk-do 369-834 Korea

OBJECTIVE Licorice is used throughout the world as a traditional herbal *** to Chinese traditional medicine licorice alone can be used to treat *** there have been some studies investigated the anti-inflammatory ingredients of licorice,but for the potency of flavonoid glycoside and their aglycones on inflammation are not *** study was designed to assess the contributions of licorice flavonoid glycosides and their aglycons to its anti-inflammatory and hypnotic *** For the flavonoid aglycone's enrichment,the extract of licorice(EL)was fermented in submerged culture of the edible fungus Grifola frondosa HB0071 mycelia which can produce β-glucosidase and catalyze the flavonoid glycosides to *** and fermented extract of licorice(FEL) were used in this *** anti-inflammation test was carried out in arachidonic acid(AA)-induced ear edema model and the hypnotic test was performed by using electroencephalogram(EEG) analysis method in normal freely moving SD *** chemicals constituents were analyzed by *** During fermentation,the falvonoid glycosides of licorice were hydrolyzed by the time *** with fermentation time,the concentration of the major flavonoid glycosides,liquiritin and isoliquiritin were decreased obviously,and simultaneously their aglycons,liquiritigenin and *** were remarkably increased in ***,the content of another major constituent *** acid and glycyrrhetinic acid were not changed after the *** AA-induced mice ear *** test,after topical application,FEL(effective dose range:5-20 μg·ear-1) showed more potent *** activity than EL(effective dose range:25-100 μg·ear-1).On the other hand,oral administration of EL and FEL exhibited the same hypnotic potency and both enhanced the total sleep time including rapid eye movement(REM) sleep and non-REM sleep *** These results suggested that the enrichment of flavon

关键词：甘草治疗方法临床分析中医

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Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung CHAE,Kyung-mi PARK,geun-youn lee,Gi-seup JEONG,Hyung-rae PARK,Hyung-min KIM,Soo-wan CHAE,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

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Development of ToSPACE for Pipe Wall Thinning Management in Nuclear Power Plants

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World Journal of Nuclear Science and Technology 2019年第1期9卷 1-15页

作者： Kyeong Mo Hwang Hun Yun Hyeok Ki Seo geun Young lee Kyung Woo Kim Material Engineering Department Gimcheon Korea ByN Company Daejeon Korea

A number of piping components in the secondary system of nuclear power plants are exposed to aging mechanisms such as FAC (Flow-Accelerated Corrosion), cavitation, flashing, SPE (Solid Particle Erosion), LDIE (Liquid Droplet Impingement Erosion), etc. Those mechanisms may lead to thinning, leak, or rupture of the components. Due to the pipe ruptures caused by wall thinning in Surry unit 2 of USA in 1986 and in Mihama unit 3 of Japan in 1994, the pipe wall thinning management has emerged as one of the most important issues in nuclear power plants. To manage the pipe wall thinning in the secondary system, Korea has used a foreign program since 1996. As using the foreign country’s program for long term, it was necessary to improve from the perspective of the users. Accordingly, KEPCO-E & C has started to develop the 3D-based pipe wall thinning management program (ToSPACE, Total Solution for Piping And Component Engineering management) from eight years ago, and the development was successful. This paper describes the major functions included in ToSPACE program, such as 3D-based DB (Database) buildup, development of FAC and erosion evaluation theories, UT (Ultra-sonic Test) data reliability analysis, field connection with 3D, automatic establishment of long-term inspection plan, etc. ToSPACE program was developed to allow site engineers performing the selection of inspection quantity at each refueling outage, UT data reliability analysis, UT evaluation, determination of next inspection timing, identification of the inspecting and replacing components in 3D drawings, etc., to access easily.

关键词： ToSPACE Pipe Wall Thinning Flow-Accelerated Corrosion (FAC) Liquid Droplet Impingement Erosion (LDIE) Reliability Analysis 3D Management Long-Term Inspection Plan

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A Heavy Precipitation Case Study Around the East China Sea in Summer Season,2006

A Heavy Precipitation Case Study Around the East China Sea i...

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第三届中日韩气象学术会议

作者： Dong-In lee Ji-Young Gu Min Jang Kil-Jong Seo Dong-Soon Kim Mi-Young Kang Sang-Min Jang geun-Ok lee Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea）

＜正＞In summer season,Korea,Japan,Taiwan and the mainland are influenced several severe weather events such as Changrna/Meiyu/Baiu front,typhoon,strong low pressure,and local heavy *** events are usually accompanied heavy precipitation and *** convective systems developing in a moist environment such as over the East China Sea are one of the major targets to reveal in meteorology as they develop rapidly and produce heavy rainfall on these *** clarify the development of the mechanism of heavy precipitation system and study its occurrence mechanism,we had field experiments in Jejudo and *** analyzed the synoptic condition by using NCEP/NCAR reanalysis data and kinematical characteristics of precipitation system by dual Doppler radar *** several cases observed,especially the case that Changma front influenced indirectly by typhoon "EWINIAR" located in south coast around Jejudo recorded heavy rainfall amount and showed special features and *** field characteristic, vertical thermal condition and synoptic condition played important *** understand occurrence mechanism of these heavy precipitation systems and monsoon etc.,long-term intensive observations should be done continuously around the East China Sea.

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