Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

作     者：Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang Hyo-Geun Lee;H.H.A.C.K.Jayawardhana;Fengqi Yang;D.P.Nagahawaththa;N.M.Liyanage;Kyung-Mo Song;Yun-Sang Choi;Seung-Hong Lee;You-Jin Jeon;Min-Cheol Kang

作者机构：Department of Marine Life SciencesJeju National UniversityJeju 63243Republic of Korea Marine Science InstituteJeju National UniversityJeju 63333Republic of Korea Research Group of Food ProcessingKorea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical EngineeringSoonchunhyang UniversityAsan 31538Republic of Korea 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第3期

页      面：1608-1616页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：The“Basic Science Research Program”extended its support via the National Research Foundation of Korea (NRF),which is sponsored through the Ministry of Education (2018R1C1B6004780) supported by Main Research Program (E0211200-03)of the Korea Food Research Institute (KFRI)funded by the Ministry of Science and ICT 

主　　题：Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis 

摘      要：The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.